Comparing the prophylaxis effect of Ondansetron and Metoclopramide against intraoperative nausea and vomiting during spinal anesthesia for cesarean section

Background and Objective: Nausea and vomiting are complications of cesarean section (C/S) during spinal anesthesia and different methods have been suggested to prevent it. The aim of this study was to compare incidence of intraoperative nausea and vomiting (IONV) during cesarean section (S/C) under...

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Autores principales:	H Zahedi, L Rouzbeh Kargar
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2004
Materias:	nausea and vomiting spinal anesthesia ondansetron metoclopramide Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a68b0a48a08847eeaf57012b1a943b3b
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spelling	oai:doaj.org-article:a68b0a48a08847eeaf57012b1a943b3b2021-11-10T09:16:12ZComparing the prophylaxis effect of Ondansetron and Metoclopramide against intraoperative nausea and vomiting during spinal anesthesia for cesarean section1561-41072251-7170https://doaj.org/article/a68b0a48a08847eeaf57012b1a943b3b2004-07-01T00:00:00Zhttp://jbums.org/article-1-2689-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and Objective: Nausea and vomiting are complications of cesarean section (C/S) during spinal anesthesia and different methods have been suggested to prevent it. The aim of this study was to compare incidence of intraoperative nausea and vomiting (IONV) during cesarean section (S/C) under spinal anesthesia. Methods: This double-blind and placebo-controlled study was performed on 150 ASA 1;2 women submitted for spinal anesthesia scheduled C/S. They were divided into three groups: 4mg ondansetron, 10mg metoclopramide or saline were administered I.V after clamping of umbilical cord, depending on their treatment group. After that treatment, if INOV appeared or the patients had no subside completely after 5 minutes, the subjects were treated with droperidol. Findings: Nausea and vomiting were not seen in 91.8% of the ondansetron group, 91.6% of the metoclopramide group and 60% of the placebo group (P<0.001). There was no significant difference between the first and second groups. Emetic symptoms were more frequent after clamping the umbilical cord (25.9%) than prior to it (16.3%) (P<0.05). Conclusion: According to the results, there was no significant difference between ondansetron and metoclopramide. For reducing IONV, it is recommended to use metoclopramide for preventing intraoperative nausea vomiting during spinal anesthesia for C/S.H ZahediL Rouzbeh KargarBabol University of Medical Sciencesarticlenausea and vomitingspinal anesthesiaondansetronmetoclopramideMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 6, Iss 3, Pp 32-36 (2004)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	nausea and vomiting spinal anesthesia ondansetron metoclopramide Medicine R Medicine (General) R5-920
spellingShingle	nausea and vomiting spinal anesthesia ondansetron metoclopramide Medicine R Medicine (General) R5-920 H Zahedi L Rouzbeh Kargar Comparing the prophylaxis effect of Ondansetron and Metoclopramide against intraoperative nausea and vomiting during spinal anesthesia for cesarean section
description	Background and Objective: Nausea and vomiting are complications of cesarean section (C/S) during spinal anesthesia and different methods have been suggested to prevent it. The aim of this study was to compare incidence of intraoperative nausea and vomiting (IONV) during cesarean section (S/C) under spinal anesthesia. Methods: This double-blind and placebo-controlled study was performed on 150 ASA 1;2 women submitted for spinal anesthesia scheduled C/S. They were divided into three groups: 4mg ondansetron, 10mg metoclopramide or saline were administered I.V after clamping of umbilical cord, depending on their treatment group. After that treatment, if INOV appeared or the patients had no subside completely after 5 minutes, the subjects were treated with droperidol. Findings: Nausea and vomiting were not seen in 91.8% of the ondansetron group, 91.6% of the metoclopramide group and 60% of the placebo group (P<0.001). There was no significant difference between the first and second groups. Emetic symptoms were more frequent after clamping the umbilical cord (25.9%) than prior to it (16.3%) (P<0.05). Conclusion: According to the results, there was no significant difference between ondansetron and metoclopramide. For reducing IONV, it is recommended to use metoclopramide for preventing intraoperative nausea vomiting during spinal anesthesia for C/S.
format	article
author	H Zahedi L Rouzbeh Kargar
author_facet	H Zahedi L Rouzbeh Kargar
author_sort	H Zahedi
title	Comparing the prophylaxis effect of Ondansetron and Metoclopramide against intraoperative nausea and vomiting during spinal anesthesia for cesarean section
title_short	Comparing the prophylaxis effect of Ondansetron and Metoclopramide against intraoperative nausea and vomiting during spinal anesthesia for cesarean section
title_full	Comparing the prophylaxis effect of Ondansetron and Metoclopramide against intraoperative nausea and vomiting during spinal anesthesia for cesarean section
title_fullStr	Comparing the prophylaxis effect of Ondansetron and Metoclopramide against intraoperative nausea and vomiting during spinal anesthesia for cesarean section
title_full_unstemmed	Comparing the prophylaxis effect of Ondansetron and Metoclopramide against intraoperative nausea and vomiting during spinal anesthesia for cesarean section
title_sort	comparing the prophylaxis effect of ondansetron and metoclopramide against intraoperative nausea and vomiting during spinal anesthesia for cesarean section
publisher	Babol University of Medical Sciences
publishDate	2004
url	https://doaj.org/article/a68b0a48a08847eeaf57012b1a943b3b
work_keys_str_mv	AT hzahedi comparingtheprophylaxiseffectofondansetronandmetoclopramideagainstintraoperativenauseaandvomitingduringspinalanesthesiaforcesareansection AT lrouzbehkargar comparingtheprophylaxiseffectofondansetronandmetoclopramideagainstintraoperativenauseaandvomitingduringspinalanesthesiaforcesareansection
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Comparing the prophylaxis effect of Ondansetron and Metoclopramide against intraoperative nausea and vomiting during spinal anesthesia for cesarean section

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