RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection

RIG-I- like receptors (RLRs) play an important role in immune defense against West Nile virus (WNV). Here, using a systems biology approach, the authors show that macrophage polarization to a proinflammatory M1 phenotype via RIG-I and MDA5 signaling is critical for innate immune control in WNV-infec...

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Autores principales:	Amy E. L. Stone, Richard Green, Courtney Wilkins, Emily A. Hemann, Michael Gale
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a68c36a70b30446d8eee27564a6f6e14
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spelling	oai:doaj.org-article:a68c36a70b30446d8eee27564a6f6e142021-12-02T17:01:33ZRIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection10.1038/s41467-019-11250-52041-1723https://doaj.org/article/a68c36a70b30446d8eee27564a6f6e142019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11250-5https://doaj.org/toc/2041-1723RIG-I- like receptors (RLRs) play an important role in immune defense against West Nile virus (WNV). Here, using a systems biology approach, the authors show that macrophage polarization to a proinflammatory M1 phenotype via RIG-I and MDA5 signaling is critical for innate immune control in WNV-infected mouse tissues.Amy E. L. StoneRichard GreenCourtney WilkinsEmily A. HemannMichael GaleNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amy E. L. Stone Richard Green Courtney Wilkins Emily A. Hemann Michael Gale RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection
description	RIG-I- like receptors (RLRs) play an important role in immune defense against West Nile virus (WNV). Here, using a systems biology approach, the authors show that macrophage polarization to a proinflammatory M1 phenotype via RIG-I and MDA5 signaling is critical for innate immune control in WNV-infected mouse tissues.
format	article
author	Amy E. L. Stone Richard Green Courtney Wilkins Emily A. Hemann Michael Gale
author_facet	Amy E. L. Stone Richard Green Courtney Wilkins Emily A. Hemann Michael Gale
author_sort	Amy E. L. Stone
title	RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection
title_short	RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection
title_full	RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection
title_fullStr	RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection
title_full_unstemmed	RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection
title_sort	rig-i-like receptors direct inflammatory macrophage polarization against west nile virus infection
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a68c36a70b30446d8eee27564a6f6e14
work_keys_str_mv	AT amyelstone rigilikereceptorsdirectinflammatorymacrophagepolarizationagainstwestnilevirusinfection AT richardgreen rigilikereceptorsdirectinflammatorymacrophagepolarizationagainstwestnilevirusinfection AT courtneywilkins rigilikereceptorsdirectinflammatorymacrophagepolarizationagainstwestnilevirusinfection AT emilyahemann rigilikereceptorsdirectinflammatorymacrophagepolarizationagainstwestnilevirusinfection AT michaelgale rigilikereceptorsdirectinflammatorymacrophagepolarizationagainstwestnilevirusinfection
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RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection

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