RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection

RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection

RIG-I- like receptors (RLRs) play an important role in immune defense against West Nile virus (WNV). Here, using a systems biology approach, the authors show that macrophage polarization to a proinflammatory M1 phenotype via RIG-I and MDA5 signaling is critical for innate immune control in WNV-infec...

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Autores principales: Amy E. L. Stone, Richard Green, Courtney Wilkins, Emily A. Hemann, Michael Gale
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/a68c36a70b30446d8eee27564a6f6e14
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