Dynamics of the 4D genome during in vivo lineage specification and differentiation

The relationship between regulatory elements, chromatin interactions and gene expression during development remains poorly understood. Here the authors present Tiled-C, a low-input 3C approach to study genome architecture at high resolution, and apply it to mouse erythroid differentiation in vivo, f...

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Autores principales:	A. Marieke Oudelaar, Robert A. Beagrie, Matthew Gosden, Sara de Ornellas, Emily Georgiades, Jon Kerry, Daniel Hidalgo, Joana Carrelha, Arun Shivalingam, Afaf H. El-Sagheer, Jelena M. Telenius, Tom Brown, Veronica J. Buckle, Merav Socolovsky, Douglas R. Higgs, Jim R. Hughes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a68d72c62d2d48089c3be17071099d2e
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spelling	oai:doaj.org-article:a68d72c62d2d48089c3be17071099d2e2021-12-02T15:56:39ZDynamics of the 4D genome during in vivo lineage specification and differentiation10.1038/s41467-020-16598-72041-1723https://doaj.org/article/a68d72c62d2d48089c3be17071099d2e2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16598-7https://doaj.org/toc/2041-1723The relationship between regulatory elements, chromatin interactions and gene expression during development remains poorly understood. Here the authors present Tiled-C, a low-input 3C approach to study genome architecture at high resolution, and apply it to mouse erythroid differentiation in vivo, finding that enhancer-promoter interactions are formed gradually during differentiation, concomitant with progressive upregulation of gene activity.A. Marieke OudelaarRobert A. BeagrieMatthew GosdenSara de OrnellasEmily GeorgiadesJon KerryDaniel HidalgoJoana CarrelhaArun ShivalingamAfaf H. El-SagheerJelena M. TeleniusTom BrownVeronica J. BuckleMerav SocolovskyDouglas R. HiggsJim R. HughesNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. Marieke Oudelaar Robert A. Beagrie Matthew Gosden Sara de Ornellas Emily Georgiades Jon Kerry Daniel Hidalgo Joana Carrelha Arun Shivalingam Afaf H. El-Sagheer Jelena M. Telenius Tom Brown Veronica J. Buckle Merav Socolovsky Douglas R. Higgs Jim R. Hughes Dynamics of the 4D genome during in vivo lineage specification and differentiation
description	The relationship between regulatory elements, chromatin interactions and gene expression during development remains poorly understood. Here the authors present Tiled-C, a low-input 3C approach to study genome architecture at high resolution, and apply it to mouse erythroid differentiation in vivo, finding that enhancer-promoter interactions are formed gradually during differentiation, concomitant with progressive upregulation of gene activity.
format	article
author	A. Marieke Oudelaar Robert A. Beagrie Matthew Gosden Sara de Ornellas Emily Georgiades Jon Kerry Daniel Hidalgo Joana Carrelha Arun Shivalingam Afaf H. El-Sagheer Jelena M. Telenius Tom Brown Veronica J. Buckle Merav Socolovsky Douglas R. Higgs Jim R. Hughes
author_facet	A. Marieke Oudelaar Robert A. Beagrie Matthew Gosden Sara de Ornellas Emily Georgiades Jon Kerry Daniel Hidalgo Joana Carrelha Arun Shivalingam Afaf H. El-Sagheer Jelena M. Telenius Tom Brown Veronica J. Buckle Merav Socolovsky Douglas R. Higgs Jim R. Hughes
author_sort	A. Marieke Oudelaar
title	Dynamics of the 4D genome during in vivo lineage specification and differentiation
title_short	Dynamics of the 4D genome during in vivo lineage specification and differentiation
title_full	Dynamics of the 4D genome during in vivo lineage specification and differentiation
title_fullStr	Dynamics of the 4D genome during in vivo lineage specification and differentiation
title_full_unstemmed	Dynamics of the 4D genome during in vivo lineage specification and differentiation
title_sort	dynamics of the 4d genome during in vivo lineage specification and differentiation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a68d72c62d2d48089c3be17071099d2e
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Dynamics of the 4D genome during in vivo lineage specification and differentiation

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