ANALYSIS OF T-HELPER SUBSETS OF PERIPHERAL BLOOD OF PATIENTS WITH CHRONIC HEPATITIS C EXPRESSING CHEMOKINE RECEPTORS CXCR3 AND CCR6 AND ACTIVATION MARKERS CD38 AND HLA-DR

Abstract. In case of hepatitis C the adequate adaptive immune response depends on T-helper lymphocyte subsets and recruiting specific T cells in the site of infection. The purpose of the study was to assess changes in subpopulations of T-helper cells bearing chemokine receptor CXCR3 and CCR6 and act...

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Autores principales:	D. S. Elezov, I. V. Kudryavtsev, N. A. Arsentieva, A. V. Semenov, E. V. Esaulenko, V. V. Basina, Areg A. Totolian
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	hepatitis c t-helpers chemokine receptors activation markers cxcr3 ccr6 cd38 hla-dr Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/a68df66256854b658bb4ad8525529a70
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spelling	oai:doaj.org-article:a68df66256854b658bb4ad8525529a702021-11-22T07:09:46ZANALYSIS OF T-HELPER SUBSETS OF PERIPHERAL BLOOD OF PATIENTS WITH CHRONIC HEPATITIS C EXPRESSING CHEMOKINE RECEPTORS CXCR3 AND CCR6 AND ACTIVATION MARKERS CD38 AND HLA-DR2220-76192313-739810.15789/2220-7619-2013-4-327-334https://doaj.org/article/a68df66256854b658bb4ad8525529a702014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/141https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. In case of hepatitis C the adequate adaptive immune response depends on T-helper lymphocyte subsets and recruiting specific T cells in the site of infection. The purpose of the study was to assess changes in subpopulations of T-helper cells bearing chemokine receptor CXCR3 and CCR6 and activation markers CD38 and HLA-DR in peripheral blood of patients with chronic hepatitis C (n = 19) and healthy donors (n = 32). The T-helper phenotype was assessed by flow cytometry using a combination of monoclonal antibodies HLA-DR-FITC/CD38-PE/CD3-ECD/CCR6-PE-Cy7/CXCR3-APC/CD4-APC-Cy7. It was demonstrated reduction of CD38+ subset, increase of CXCR3+ and CCR6+ subsets of T-helper cells in particular CD3+CD4+ CXCR3+CCR6+ cells and importance of joint determination of the chemokine receptors CXCR3 and CCR6 and the activation markers CD38 and HLA-DR compared to their separate analysis in chronic hepatitis C.D. S. ElezovI. V. KudryavtsevN. A. ArsentievaA. V. SemenovE. V. EsaulenkoV. V. BasinaAreg A. TotolianSankt-Peterburg : NIIÈM imeni Pasteraarticlehepatitis ct-helperschemokine receptorsactivation markerscxcr3ccr6cd38hla-drInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 3, Iss 4, Pp 327-334 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	hepatitis c t-helpers chemokine receptors activation markers cxcr3 ccr6 cd38 hla-dr Infectious and parasitic diseases RC109-216
spellingShingle	hepatitis c t-helpers chemokine receptors activation markers cxcr3 ccr6 cd38 hla-dr Infectious and parasitic diseases RC109-216 D. S. Elezov I. V. Kudryavtsev N. A. Arsentieva A. V. Semenov E. V. Esaulenko V. V. Basina Areg A. Totolian ANALYSIS OF T-HELPER SUBSETS OF PERIPHERAL BLOOD OF PATIENTS WITH CHRONIC HEPATITIS C EXPRESSING CHEMOKINE RECEPTORS CXCR3 AND CCR6 AND ACTIVATION MARKERS CD38 AND HLA-DR
description	Abstract. In case of hepatitis C the adequate adaptive immune response depends on T-helper lymphocyte subsets and recruiting specific T cells in the site of infection. The purpose of the study was to assess changes in subpopulations of T-helper cells bearing chemokine receptor CXCR3 and CCR6 and activation markers CD38 and HLA-DR in peripheral blood of patients with chronic hepatitis C (n = 19) and healthy donors (n = 32). The T-helper phenotype was assessed by flow cytometry using a combination of monoclonal antibodies HLA-DR-FITC/CD38-PE/CD3-ECD/CCR6-PE-Cy7/CXCR3-APC/CD4-APC-Cy7. It was demonstrated reduction of CD38+ subset, increase of CXCR3+ and CCR6+ subsets of T-helper cells in particular CD3+CD4+ CXCR3+CCR6+ cells and importance of joint determination of the chemokine receptors CXCR3 and CCR6 and the activation markers CD38 and HLA-DR compared to their separate analysis in chronic hepatitis C.
format	article
author	D. S. Elezov I. V. Kudryavtsev N. A. Arsentieva A. V. Semenov E. V. Esaulenko V. V. Basina Areg A. Totolian
author_facet	D. S. Elezov I. V. Kudryavtsev N. A. Arsentieva A. V. Semenov E. V. Esaulenko V. V. Basina Areg A. Totolian
author_sort	D. S. Elezov
title	ANALYSIS OF T-HELPER SUBSETS OF PERIPHERAL BLOOD OF PATIENTS WITH CHRONIC HEPATITIS C EXPRESSING CHEMOKINE RECEPTORS CXCR3 AND CCR6 AND ACTIVATION MARKERS CD38 AND HLA-DR
title_short	ANALYSIS OF T-HELPER SUBSETS OF PERIPHERAL BLOOD OF PATIENTS WITH CHRONIC HEPATITIS C EXPRESSING CHEMOKINE RECEPTORS CXCR3 AND CCR6 AND ACTIVATION MARKERS CD38 AND HLA-DR
title_full	ANALYSIS OF T-HELPER SUBSETS OF PERIPHERAL BLOOD OF PATIENTS WITH CHRONIC HEPATITIS C EXPRESSING CHEMOKINE RECEPTORS CXCR3 AND CCR6 AND ACTIVATION MARKERS CD38 AND HLA-DR
title_fullStr	ANALYSIS OF T-HELPER SUBSETS OF PERIPHERAL BLOOD OF PATIENTS WITH CHRONIC HEPATITIS C EXPRESSING CHEMOKINE RECEPTORS CXCR3 AND CCR6 AND ACTIVATION MARKERS CD38 AND HLA-DR
title_full_unstemmed	ANALYSIS OF T-HELPER SUBSETS OF PERIPHERAL BLOOD OF PATIENTS WITH CHRONIC HEPATITIS C EXPRESSING CHEMOKINE RECEPTORS CXCR3 AND CCR6 AND ACTIVATION MARKERS CD38 AND HLA-DR
title_sort	analysis of t-helper subsets of peripheral blood of patients with chronic hepatitis c expressing chemokine receptors cxcr3 and ccr6 and activation markers cd38 and hla-dr
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/a68df66256854b658bb4ad8525529a70
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ANALYSIS OF T-HELPER SUBSETS OF PERIPHERAL BLOOD OF PATIENTS WITH CHRONIC HEPATITIS C EXPRESSING CHEMOKINE RECEPTORS CXCR3 AND CCR6 AND ACTIVATION MARKERS CD38 AND HLA-DR

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