A non-optimal cervicovaginal microbiota in pregnancy is associated with a distinct metabolomic signature among non-Hispanic Black individuals

Abstract Biomechanical and molecular processes of premature cervical remodeling preceding spontaneous preterm birth (sPTB) likely result from interactions between the cervicovaginal microbiota and host immune responses. A non-optimal cervicovaginal microbiota confers increased risk of sPTB. The cerv...

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Autores principales:	Kristin D. Gerson, Jingqiu Liao, Clare McCarthy, Heather H. Burris, Tal Korem, Maayan Levy, Jacques Ravel, Michal A. Elovitz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a6942596107c479195ab52445640d63b
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spelling	oai:doaj.org-article:a6942596107c479195ab52445640d63b2021-11-28T12:18:35ZA non-optimal cervicovaginal microbiota in pregnancy is associated with a distinct metabolomic signature among non-Hispanic Black individuals10.1038/s41598-021-02304-02045-2322https://doaj.org/article/a6942596107c479195ab52445640d63b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02304-0https://doaj.org/toc/2045-2322Abstract Biomechanical and molecular processes of premature cervical remodeling preceding spontaneous preterm birth (sPTB) likely result from interactions between the cervicovaginal microbiota and host immune responses. A non-optimal cervicovaginal microbiota confers increased risk of sPTB. The cervicovaginal space is metabolically active in pregancy; microbiota can produce, modify, and degrade metabolites within this ecosystem. We establish that cervicovaginal metabolomic output clusters by microbial community in pregnancy among Black individuals, revealing increased metabolism within the amino acid and dipeptide pathways as hallmarks of a non-optimal microbiota. Few differences were detected in metabolomic profiles when stratified by birth outcome. The study raises the possibility that metabolites could distinguish women with greater risk of sPTB among those with similar cervicovaginal microbiota, and that metabolites within the amino acid and carbohydrate pathways may play a role in this distinction.Kristin D. GersonJingqiu LiaoClare McCarthyHeather H. BurrisTal KoremMaayan LevyJacques RavelMichal A. ElovitzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kristin D. Gerson Jingqiu Liao Clare McCarthy Heather H. Burris Tal Korem Maayan Levy Jacques Ravel Michal A. Elovitz A non-optimal cervicovaginal microbiota in pregnancy is associated with a distinct metabolomic signature among non-Hispanic Black individuals
description	Abstract Biomechanical and molecular processes of premature cervical remodeling preceding spontaneous preterm birth (sPTB) likely result from interactions between the cervicovaginal microbiota and host immune responses. A non-optimal cervicovaginal microbiota confers increased risk of sPTB. The cervicovaginal space is metabolically active in pregancy; microbiota can produce, modify, and degrade metabolites within this ecosystem. We establish that cervicovaginal metabolomic output clusters by microbial community in pregnancy among Black individuals, revealing increased metabolism within the amino acid and dipeptide pathways as hallmarks of a non-optimal microbiota. Few differences were detected in metabolomic profiles when stratified by birth outcome. The study raises the possibility that metabolites could distinguish women with greater risk of sPTB among those with similar cervicovaginal microbiota, and that metabolites within the amino acid and carbohydrate pathways may play a role in this distinction.
format	article
author	Kristin D. Gerson Jingqiu Liao Clare McCarthy Heather H. Burris Tal Korem Maayan Levy Jacques Ravel Michal A. Elovitz
author_facet	Kristin D. Gerson Jingqiu Liao Clare McCarthy Heather H. Burris Tal Korem Maayan Levy Jacques Ravel Michal A. Elovitz
author_sort	Kristin D. Gerson
title	A non-optimal cervicovaginal microbiota in pregnancy is associated with a distinct metabolomic signature among non-Hispanic Black individuals
title_short	A non-optimal cervicovaginal microbiota in pregnancy is associated with a distinct metabolomic signature among non-Hispanic Black individuals
title_full	A non-optimal cervicovaginal microbiota in pregnancy is associated with a distinct metabolomic signature among non-Hispanic Black individuals
title_fullStr	A non-optimal cervicovaginal microbiota in pregnancy is associated with a distinct metabolomic signature among non-Hispanic Black individuals
title_full_unstemmed	A non-optimal cervicovaginal microbiota in pregnancy is associated with a distinct metabolomic signature among non-Hispanic Black individuals
title_sort	non-optimal cervicovaginal microbiota in pregnancy is associated with a distinct metabolomic signature among non-hispanic black individuals
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a6942596107c479195ab52445640d63b
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A non-optimal cervicovaginal microbiota in pregnancy is associated with a distinct metabolomic signature among non-Hispanic Black individuals

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