Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons
Using an unbiased genome-wide CRISPR screen approach, Sanchez et al. identified modulators of endogenous tau protein. This study suggests that chromatin modifiers, neddylation, ubiquitination, and the mTOR pathways regulate overall levels of tau protein in neurons, which could help in future identif...
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Nature Portfolio
2021
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oai:doaj.org-article:a6974f96fa3e43eca73250a0892da4a22021-12-02T16:04:35ZGenome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons10.1038/s42003-021-02272-12399-3642https://doaj.org/article/a6974f96fa3e43eca73250a0892da4a22021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02272-1https://doaj.org/toc/2399-3642Using an unbiased genome-wide CRISPR screen approach, Sanchez et al. identified modulators of endogenous tau protein. This study suggests that chromatin modifiers, neddylation, ubiquitination, and the mTOR pathways regulate overall levels of tau protein in neurons, which could help in future identification of therapeutics for neurodegenerative diseases.Carlos G. SanchezChristopher M. AckerAudrey GrayMalini VaradarajanCheng SongNadire R. CochranSteven PaulaAlicia LindemanShaojian AnGregory McAllisterJohn AlfordJohn Reece-HoyesCarsten RussLucas CraigKetthsy CapreChristian DohertyGregory R. HoffmanSarah J. LuchanskyManuela PolydoroRicardo DolmetschFiona ElwoodNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 Carlos G. Sanchez Christopher M. Acker Audrey Gray Malini Varadarajan Cheng Song Nadire R. Cochran Steven Paula Alicia Lindeman Shaojian An Gregory McAllister John Alford John Reece-Hoyes Carsten Russ Lucas Craig Ketthsy Capre Christian Doherty Gregory R. Hoffman Sarah J. Luchansky Manuela Polydoro Ricardo Dolmetsch Fiona Elwood Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons |
| description |
Using an unbiased genome-wide CRISPR screen approach, Sanchez et al. identified modulators of endogenous tau protein. This study suggests that chromatin modifiers, neddylation, ubiquitination, and the mTOR pathways regulate overall levels of tau protein in neurons, which could help in future identification of therapeutics for neurodegenerative diseases. |
| format |
article |
| author |
Carlos G. Sanchez Christopher M. Acker Audrey Gray Malini Varadarajan Cheng Song Nadire R. Cochran Steven Paula Alicia Lindeman Shaojian An Gregory McAllister John Alford John Reece-Hoyes Carsten Russ Lucas Craig Ketthsy Capre Christian Doherty Gregory R. Hoffman Sarah J. Luchansky Manuela Polydoro Ricardo Dolmetsch Fiona Elwood |
| author_facet |
Carlos G. Sanchez Christopher M. Acker Audrey Gray Malini Varadarajan Cheng Song Nadire R. Cochran Steven Paula Alicia Lindeman Shaojian An Gregory McAllister John Alford John Reece-Hoyes Carsten Russ Lucas Craig Ketthsy Capre Christian Doherty Gregory R. Hoffman Sarah J. Luchansky Manuela Polydoro Ricardo Dolmetsch Fiona Elwood |
| author_sort |
Carlos G. Sanchez |
| title |
Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons |
| title_short |
Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons |
| title_full |
Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons |
| title_fullStr |
Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons |
| title_full_unstemmed |
Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons |
| title_sort |
genome-wide crispr screen identifies protein pathways modulating tau protein levels in neurons |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/a6974f96fa3e43eca73250a0892da4a2 |
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