Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum

Myeloid-derived growth factor (MYDGF) is an endoplasmic reticulum protein of therapeutic interest because it promotes tissue repair in a murine model of myocardial infarction. Here the authors present the NMR structure of human MYDGF and attribute function to a set of residues conserved in MYDGFs bu...

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Autores principales:	Valeriu Bortnov, Marco Tonelli, Woonghee Lee, Ziqing Lin, Douglas S. Annis, Omar N. Demerdash, Alex Bateman, Julie C. Mitchell, Ying Ge, John L. Markley, Deane F. Mosher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a6990a6e878247dcb11d2880bc0fb764
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spelling	oai:doaj.org-article:a6990a6e878247dcb11d2880bc0fb7642021-12-02T17:01:29ZSolution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum10.1038/s41467-019-13577-52041-1723https://doaj.org/article/a6990a6e878247dcb11d2880bc0fb7642019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13577-5https://doaj.org/toc/2041-1723Myeloid-derived growth factor (MYDGF) is an endoplasmic reticulum protein of therapeutic interest because it promotes tissue repair in a murine model of myocardial infarction. Here the authors present the NMR structure of human MYDGF and attribute function to a set of residues conserved in MYDGFs but not the vanin base domain, which has a similar fold.Valeriu BortnovMarco TonelliWoonghee LeeZiqing LinDouglas S. AnnisOmar N. DemerdashAlex BatemanJulie C. MitchellYing GeJohn L. MarkleyDeane F. MosherNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Valeriu Bortnov Marco Tonelli Woonghee Lee Ziqing Lin Douglas S. Annis Omar N. Demerdash Alex Bateman Julie C. Mitchell Ying Ge John L. Markley Deane F. Mosher Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum
description	Myeloid-derived growth factor (MYDGF) is an endoplasmic reticulum protein of therapeutic interest because it promotes tissue repair in a murine model of myocardial infarction. Here the authors present the NMR structure of human MYDGF and attribute function to a set of residues conserved in MYDGFs but not the vanin base domain, which has a similar fold.
format	article
author	Valeriu Bortnov Marco Tonelli Woonghee Lee Ziqing Lin Douglas S. Annis Omar N. Demerdash Alex Bateman Julie C. Mitchell Ying Ge John L. Markley Deane F. Mosher
author_facet	Valeriu Bortnov Marco Tonelli Woonghee Lee Ziqing Lin Douglas S. Annis Omar N. Demerdash Alex Bateman Julie C. Mitchell Ying Ge John L. Markley Deane F. Mosher
author_sort	Valeriu Bortnov
title	Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum
title_short	Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum
title_full	Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum
title_fullStr	Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum
title_full_unstemmed	Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum
title_sort	solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a6990a6e878247dcb11d2880bc0fb764
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Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum

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