The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies

Thiazolidin-4-ones is an important heterocyclic ring system of a pharmacophore and a privileged scaffold in medicinal chemistry. This review is focused on the latest scientific reports regarding biological activities of thiazolidin-4-ones published in 2020 and 2021. The review covers recent informat...

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Autores principales:	Dominika Mech, Antonina Kurowska, Nazar Trotsko
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	thiazolidine-4-ones antioxidant activity anticancer activity anti-inflammatory activity antidiabetic activity antiparasitic activity Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/a6995943bf8f46cea6b9557cba82c1ca
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spelling	oai:doaj.org-article:a6995943bf8f46cea6b9557cba82c1ca2021-11-11T16:59:45ZThe Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies10.3390/ijms2221115331422-00671661-6596https://doaj.org/article/a6995943bf8f46cea6b9557cba82c1ca2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11533https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Thiazolidin-4-ones is an important heterocyclic ring system of a pharmacophore and a privileged scaffold in medicinal chemistry. This review is focused on the latest scientific reports regarding biological activities of thiazolidin-4-ones published in 2020 and 2021. The review covers recent information about antioxidant, anticancer, anti-inflammatory, analgesic, anticonvulsant, antidiabetic, antiparasitic, antimicrobial, antitubercular and antiviral properties of thiazolidin-4-ones. Additionally, the influence of different substituents in molecules on their biological activity was discussed in this paper. Thus, this study may help to optimize the structure of thiazolidin-4-one derivatives as more efficient drug agents. Presented information may be used as a practical hint for rational design of new small molecules with biological activity, especially among thiazolidin-4-ones.Dominika MechAntonina KurowskaNazar TrotskoMDPI AGarticlethiazolidine-4-onesantioxidant activityanticancer activityanti-inflammatory activityantidiabetic activityantiparasitic activityBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11533, p 11533 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	thiazolidine-4-ones antioxidant activity anticancer activity anti-inflammatory activity antidiabetic activity antiparasitic activity Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	thiazolidine-4-ones antioxidant activity anticancer activity anti-inflammatory activity antidiabetic activity antiparasitic activity Biology (General) QH301-705.5 Chemistry QD1-999 Dominika Mech Antonina Kurowska Nazar Trotsko The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies
description	Thiazolidin-4-ones is an important heterocyclic ring system of a pharmacophore and a privileged scaffold in medicinal chemistry. This review is focused on the latest scientific reports regarding biological activities of thiazolidin-4-ones published in 2020 and 2021. The review covers recent information about antioxidant, anticancer, anti-inflammatory, analgesic, anticonvulsant, antidiabetic, antiparasitic, antimicrobial, antitubercular and antiviral properties of thiazolidin-4-ones. Additionally, the influence of different substituents in molecules on their biological activity was discussed in this paper. Thus, this study may help to optimize the structure of thiazolidin-4-one derivatives as more efficient drug agents. Presented information may be used as a practical hint for rational design of new small molecules with biological activity, especially among thiazolidin-4-ones.
format	article
author	Dominika Mech Antonina Kurowska Nazar Trotsko
author_facet	Dominika Mech Antonina Kurowska Nazar Trotsko
author_sort	Dominika Mech
title	The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies
title_short	The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies
title_full	The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies
title_fullStr	The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies
title_full_unstemmed	The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies
title_sort	bioactivity of thiazolidin-4-ones: a short review of the most recent studies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a6995943bf8f46cea6b9557cba82c1ca
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The Bioactivity of Thiazolidin-4-Ones: A Short Review of the Most Recent Studies

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