Relationship between malnutrition and possible sarcopenia in the AWGS 2019 consensus affecting mortality in hemodialysis patients: a prospective cohort study

Abstract Background The first objective of this study was to determine the relationship between muscle strength or physical performance and mortality, and the second objective was to show the relationship of Geriatric Nutritional Risk Index (GNRI) to muscle strength and physical performance decline....

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Autores principales:	Kenichi Kono, Yoshifumi Moriyama, Hiroki Yabe, Ayaka Hara, Takeki Ishida, Tetsuya Yamada, Yusuke Nishida
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Possible sarcopenia Handgrip strength GNRI Mortality Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/a69aa1eff06f4be18951f05f19a1bd5e
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spelling	oai:doaj.org-article:a69aa1eff06f4be18951f05f19a1bd5e2021-11-14T12:43:53ZRelationship between malnutrition and possible sarcopenia in the AWGS 2019 consensus affecting mortality in hemodialysis patients: a prospective cohort study10.1186/s12882-021-02566-w1471-2369https://doaj.org/article/a69aa1eff06f4be18951f05f19a1bd5e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12882-021-02566-whttps://doaj.org/toc/1471-2369Abstract Background The first objective of this study was to determine the relationship between muscle strength or physical performance and mortality, and the second objective was to show the relationship of Geriatric Nutritional Risk Index (GNRI) to muscle strength and physical performance decline. Methods We examined handgrip, the 5-times chair stand test, and GNRI in 635 maintenance hemodialysis patients and followed up for 72 months. Predictors for all-cause death were examined using Kaplan-Meier analysis and Cox proportional analysis. The relationship between possible sarcopenia and nutritional disorder (GNRI) was constructed receiver operating characteristic (ROC) curve. We used the Youden index to determine the optimal cutoff points for GNRI. Results The multivariate Cox proportional hazard analysis revealed that the GNRI did not show any significance, although handgrip (HR 3.61, 95% CI 1.70–7.68, p < 0.001) and the 5-times chair stand test (HR 1.71 95% CI 1.01–2.90, p = 0.045) were significant predictors for mortality. On the evaluation of possible sarcopenia by handgrip strength, the area under curve (AUC) on ROC curve analysis were 0.68 (95% CI 0.64–0.72), and 5-chair stand, the AUC on ROC were 0.55 (95% CI 0.51–0.60). The cut-off value for the GNRI discriminating those at possible sarcopenia by handgrip strength based on the Youden index was 91.5. Conclusions Our study suggests that the handgrip strength test of the AWGS 2019 sarcopenia consensus was a simple and useful tool to predict mortality in chronic hemodialysis patients. Furthermore, GNRI assessment can be a useful tool for screening before assessing possible sarcopenia when it is difficult to perform SARC-F to all patients.Kenichi KonoYoshifumi MoriyamaHiroki YabeAyaka HaraTakeki IshidaTetsuya YamadaYusuke NishidaBMCarticlePossible sarcopeniaHandgrip strengthGNRIMortalityDiseases of the genitourinary system. UrologyRC870-923ENBMC Nephrology, Vol 22, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Possible sarcopenia Handgrip strength GNRI Mortality Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Possible sarcopenia Handgrip strength GNRI Mortality Diseases of the genitourinary system. Urology RC870-923 Kenichi Kono Yoshifumi Moriyama Hiroki Yabe Ayaka Hara Takeki Ishida Tetsuya Yamada Yusuke Nishida Relationship between malnutrition and possible sarcopenia in the AWGS 2019 consensus affecting mortality in hemodialysis patients: a prospective cohort study
description	Abstract Background The first objective of this study was to determine the relationship between muscle strength or physical performance and mortality, and the second objective was to show the relationship of Geriatric Nutritional Risk Index (GNRI) to muscle strength and physical performance decline. Methods We examined handgrip, the 5-times chair stand test, and GNRI in 635 maintenance hemodialysis patients and followed up for 72 months. Predictors for all-cause death were examined using Kaplan-Meier analysis and Cox proportional analysis. The relationship between possible sarcopenia and nutritional disorder (GNRI) was constructed receiver operating characteristic (ROC) curve. We used the Youden index to determine the optimal cutoff points for GNRI. Results The multivariate Cox proportional hazard analysis revealed that the GNRI did not show any significance, although handgrip (HR 3.61, 95% CI 1.70–7.68, p < 0.001) and the 5-times chair stand test (HR 1.71 95% CI 1.01–2.90, p = 0.045) were significant predictors for mortality. On the evaluation of possible sarcopenia by handgrip strength, the area under curve (AUC) on ROC curve analysis were 0.68 (95% CI 0.64–0.72), and 5-chair stand, the AUC on ROC were 0.55 (95% CI 0.51–0.60). The cut-off value for the GNRI discriminating those at possible sarcopenia by handgrip strength based on the Youden index was 91.5. Conclusions Our study suggests that the handgrip strength test of the AWGS 2019 sarcopenia consensus was a simple and useful tool to predict mortality in chronic hemodialysis patients. Furthermore, GNRI assessment can be a useful tool for screening before assessing possible sarcopenia when it is difficult to perform SARC-F to all patients.
format	article
author	Kenichi Kono Yoshifumi Moriyama Hiroki Yabe Ayaka Hara Takeki Ishida Tetsuya Yamada Yusuke Nishida
author_facet	Kenichi Kono Yoshifumi Moriyama Hiroki Yabe Ayaka Hara Takeki Ishida Tetsuya Yamada Yusuke Nishida
author_sort	Kenichi Kono
title	Relationship between malnutrition and possible sarcopenia in the AWGS 2019 consensus affecting mortality in hemodialysis patients: a prospective cohort study
title_short	Relationship between malnutrition and possible sarcopenia in the AWGS 2019 consensus affecting mortality in hemodialysis patients: a prospective cohort study
title_full	Relationship between malnutrition and possible sarcopenia in the AWGS 2019 consensus affecting mortality in hemodialysis patients: a prospective cohort study
title_fullStr	Relationship between malnutrition and possible sarcopenia in the AWGS 2019 consensus affecting mortality in hemodialysis patients: a prospective cohort study
title_full_unstemmed	Relationship between malnutrition and possible sarcopenia in the AWGS 2019 consensus affecting mortality in hemodialysis patients: a prospective cohort study
title_sort	relationship between malnutrition and possible sarcopenia in the awgs 2019 consensus affecting mortality in hemodialysis patients: a prospective cohort study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/a69aa1eff06f4be18951f05f19a1bd5e
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_version_	1718429065999810560

Relationship between malnutrition and possible sarcopenia in the AWGS 2019 consensus affecting mortality in hemodialysis patients: a prospective cohort study

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