Role of anti-GQ1B antibody in differential diagnosis of acute ophthalmoparesis
E Ece Boylu, R Erdem Togrol, Mehmet Güney Şenol, M Fatih Özdag, Mehmet SaraçogluGATA Hadarpaşa Educational and Research Hospital, Department of Neurology, Istanbul, TurkeyAbstract: Miller Fisher syndrome (MFS) is a triad of total external ophthalmoplegia, ata...
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Dove Medical Press
2010
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oai:doaj.org-article:a69dcbad8fd34466a022f4c3c31819332021-12-02T06:33:36ZRole of anti-GQ1B antibody in differential diagnosis of acute ophthalmoparesis1176-63281178-2021https://doaj.org/article/a69dcbad8fd34466a022f4c3c31819332010-04-01T00:00:00Zhttp://www.dovepress.com/role-of-anti-gq1b-antibody-in-differential-diagnosis-of-acute-ophthalm-a4208https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021E Ece Boylu, R Erdem Togrol, Mehmet Güney Şenol, M Fatih Özdag, Mehmet SaraçogluGATA Hadarpaşa Educational and Research Hospital, Department of Neurology, Istanbul, TurkeyAbstract: Miller Fisher syndrome (MFS) is a triad of total external ophthalmoplegia, ataxia, and areflexia, while botulism has the usual clinical presentation of involvement of cranial muscles and palsies with blurred vision, diplopia, ptosis, dilated pupils, and facial paralysis, caused by a bacterial neurotoxin which attacks proteins involved in presynaptic vesicle release. In this report, we needed to make the differential diagnosis between MFS and botulism in a patient who presented with acute ophthalmoparesis and a history of diarrhea three days before, which started two days after consuming tinned food. Routine laboratory, neurophysiologic, and imaging investigations were normal. A clinical diagnosis of Miller Fisher syndrome was reached by anti-ganglioside GQ1B and GM1 Ig G and M antibody investigations which proved positive. The patient was treated with intravenous immunoglobulin two weeks after (in the late period) the symptoms started and he has recovered completely. Systemic autoimmune diseases should be considered in patients with bilateral ophthalmoparesis. As in the present patient, the evaluation of specific antibodies helps in the diagnosis and thus early effective treatment is possible.Keywords: anti-ganglioside antibody, botulism, Miller Fisher syndrome, ophthalmoparesis E Ece BoyluR Erdem TogrolMehmet Güney Şenolet alDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2010, Iss Issue 1, Pp 119-122 (2010) |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 E Ece Boylu R Erdem Togrol Mehmet Güney Şenol et al Role of anti-GQ1B antibody in differential diagnosis of acute ophthalmoparesis |
| description |
E Ece Boylu, R Erdem Togrol, Mehmet Güney Şenol, M Fatih Özdag, Mehmet SaraçogluGATA Hadarpaşa Educational and Research Hospital, Department of Neurology, Istanbul, TurkeyAbstract: Miller Fisher syndrome (MFS) is a triad of total external ophthalmoplegia, ataxia, and areflexia, while botulism has the usual clinical presentation of involvement of cranial muscles and palsies with blurred vision, diplopia, ptosis, dilated pupils, and facial paralysis, caused by a bacterial neurotoxin which attacks proteins involved in presynaptic vesicle release. In this report, we needed to make the differential diagnosis between MFS and botulism in a patient who presented with acute ophthalmoparesis and a history of diarrhea three days before, which started two days after consuming tinned food. Routine laboratory, neurophysiologic, and imaging investigations were normal. A clinical diagnosis of Miller Fisher syndrome was reached by anti-ganglioside GQ1B and GM1 Ig G and M antibody investigations which proved positive. The patient was treated with intravenous immunoglobulin two weeks after (in the late period) the symptoms started and he has recovered completely. Systemic autoimmune diseases should be considered in patients with bilateral ophthalmoparesis. As in the present patient, the evaluation of specific antibodies helps in the diagnosis and thus early effective treatment is possible.Keywords: anti-ganglioside antibody, botulism, Miller Fisher syndrome, ophthalmoparesis |
| format |
article |
| author |
E Ece Boylu R Erdem Togrol Mehmet Güney Şenol et al |
| author_facet |
E Ece Boylu R Erdem Togrol Mehmet Güney Şenol et al |
| author_sort |
E Ece Boylu |
| title |
Role of anti-GQ1B antibody in differential diagnosis of acute ophthalmoparesis |
| title_short |
Role of anti-GQ1B antibody in differential diagnosis of acute ophthalmoparesis |
| title_full |
Role of anti-GQ1B antibody in differential diagnosis of acute ophthalmoparesis |
| title_fullStr |
Role of anti-GQ1B antibody in differential diagnosis of acute ophthalmoparesis |
| title_full_unstemmed |
Role of anti-GQ1B antibody in differential diagnosis of acute ophthalmoparesis |
| title_sort |
role of anti-gq1b antibody in differential diagnosis of acute ophthalmoparesis |
| publisher |
Dove Medical Press |
| publishDate |
2010 |
| url |
https://doaj.org/article/a69dcbad8fd34466a022f4c3c3181933 |
| work_keys_str_mv |
AT eeceboylu roleofantigq1bantibodyindifferentialdiagnosisofacuteophthalmoparesis AT rerdemtogrol roleofantigq1bantibodyindifferentialdiagnosisofacuteophthalmoparesis AT mehmetgampuumlneysenol roleofantigq1bantibodyindifferentialdiagnosisofacuteophthalmoparesis AT etal roleofantigq1bantibodyindifferentialdiagnosisofacuteophthalmoparesis |
| _version_ |
1718399893297430528 |