Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia

Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia

Ten-eleven translocation 1 (TET1) is a critical oncoprotein in AML. Here, the authors identify 2 compounds that target the binding of STAT3/5 specifically to the TET1 promoter, inhibiting its expression and AML cell viability.

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Autores principales: Xi Jiang, Chao Hu, Kyle Ferchen, Ji Nie, Xiaolong Cui, Chih-Hong Chen, Liting Cheng, Zhixiang Zuo, William Seibel, Chunjiang He, Yixuan Tang, Jennifer R. Skibbe, Mark Wunderlich, William C. Reinhold, Lei Dong, Chao Shen, Stephen Arnovitz, Bryan Ulrich, Jiuwei Lu, Hengyou Weng, Rui Su, Huilin Huang, Yungui Wang, Chenying Li, Xi Qin, James C. Mulloy, Yi Zheng, Jiajie Diao, Jie Jin, Chong Li, Paul P. Liu, Chuan He, Yuan Chen, Jianjun Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/a69ded8bba8e453aab53549f9efffc05
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spelling oai:doaj.org-article:a69ded8bba8e453aab53549f9efffc052021-12-02T14:42:34ZTargeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia10.1038/s41467-017-02290-w2041-1723https://doaj.org/article/a69ded8bba8e453aab53549f9efffc052017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02290-whttps://doaj.org/toc/2041-1723Ten-eleven translocation 1 (TET1) is a critical oncoprotein in AML. Here, the authors identify 2 compounds that target the binding of STAT3/5 specifically to the TET1 promoter, inhibiting its expression and AML cell viability.Xi JiangChao HuKyle FerchenJi NieXiaolong CuiChih-Hong ChenLiting ChengZhixiang ZuoWilliam SeibelChunjiang HeYixuan TangJennifer R. SkibbeMark WunderlichWilliam C. ReinholdLei DongChao ShenStephen ArnovitzBryan UlrichJiuwei LuHengyou WengRui SuHuilin HuangYungui WangChenying LiXi QinJames C. MulloyYi ZhengJiajie DiaoJie JinChong LiPaul P. LiuChuan HeYuan ChenJianjun ChenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xi Jiang
Chao Hu
Kyle Ferchen
Ji Nie
Xiaolong Cui
Chih-Hong Chen
Liting Cheng
Zhixiang Zuo
William Seibel
Chunjiang He
Yixuan Tang
Jennifer R. Skibbe
Mark Wunderlich
William C. Reinhold
Lei Dong
Chao Shen
Stephen Arnovitz
Bryan Ulrich
Jiuwei Lu
Hengyou Weng
Rui Su
Huilin Huang
Yungui Wang
Chenying Li
Xi Qin
James C. Mulloy
Yi Zheng
Jiajie Diao
Jie Jin
Chong Li
Paul P. Liu
Chuan He
Yuan Chen
Jianjun Chen
Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia
description Ten-eleven translocation 1 (TET1) is a critical oncoprotein in AML. Here, the authors identify 2 compounds that target the binding of STAT3/5 specifically to the TET1 promoter, inhibiting its expression and AML cell viability.
format article
author Xi Jiang
Chao Hu
Kyle Ferchen
Ji Nie
Xiaolong Cui
Chih-Hong Chen
Liting Cheng
Zhixiang Zuo
William Seibel
Chunjiang He
Yixuan Tang
Jennifer R. Skibbe
Mark Wunderlich
William C. Reinhold
Lei Dong
Chao Shen
Stephen Arnovitz
Bryan Ulrich
Jiuwei Lu
Hengyou Weng
Rui Su
Huilin Huang
Yungui Wang
Chenying Li
Xi Qin
James C. Mulloy
Yi Zheng
Jiajie Diao
Jie Jin
Chong Li
Paul P. Liu
Chuan He
Yuan Chen
Jianjun Chen
author_facet Xi Jiang
Chao Hu
Kyle Ferchen
Ji Nie
Xiaolong Cui
Chih-Hong Chen
Liting Cheng
Zhixiang Zuo
William Seibel
Chunjiang He
Yixuan Tang
Jennifer R. Skibbe
Mark Wunderlich
William C. Reinhold
Lei Dong
Chao Shen
Stephen Arnovitz
Bryan Ulrich
Jiuwei Lu
Hengyou Weng
Rui Su
Huilin Huang
Yungui Wang
Chenying Li
Xi Qin
James C. Mulloy
Yi Zheng
Jiajie Diao
Jie Jin
Chong Li
Paul P. Liu
Chuan He
Yuan Chen
Jianjun Chen
author_sort Xi Jiang
title Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia
title_short Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia
title_full Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia
title_fullStr Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia
title_full_unstemmed Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia
title_sort targeted inhibition of stat/tet1 axis as a therapeutic strategy for acute myeloid leukemia
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/a69ded8bba8e453aab53549f9efffc05
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