Carbon nanoparticles downregulate expression of basic fibroblast growth factor in the heart during embryogenesis

Mateusz Wierzbicki,1 Ewa Sawosz,1 Marta Grodzik,1 Anna Hotowy,1 Marta Prasek,1 Slawomir Jaworski,1 Filip Sawosz,2 André Chwalibog2 1Division of Nanobiotechnology, Warsaw University of Life Sciences, Warsaw, Poland; 2Department of Veterinary Clinical and Animal Sciences, University of Cope...

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Autores principales:	Wierzbicki M, Sawosz E, Grodzik M, Hotowy A, Prasek M, Jaworski S, Sawosz F, Chwalibog A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a69deeaaeb704702936894752e5325dd
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spelling	oai:doaj.org-article:a69deeaaeb704702936894752e5325dd2021-12-02T00:22:13ZCarbon nanoparticles downregulate expression of basic fibroblast growth factor in the heart during embryogenesis1176-91141178-2013https://doaj.org/article/a69deeaaeb704702936894752e5325dd2013-09-01T00:00:00Zhttp://www.dovepress.com/carbon-nanoparticles-downregulate-expression-of-basic-fibroblast-growt-a14280https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Mateusz Wierzbicki,1 Ewa Sawosz,1 Marta Grodzik,1 Anna Hotowy,1 Marta Prasek,1 Slawomir Jaworski,1 Filip Sawosz,2 André Chwalibog2 1Division of Nanobiotechnology, Warsaw University of Life Sciences, Warsaw, Poland; 2Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, Copenhagen, Denmark Abstract: Carbon nanoparticles, with their high biocompatibility and low toxicity, have recently been considered for biomedical applications, including antiangiogenic therapy. Critical to normal development and tumor formation, angiogenesis is the process of forming capillary blood vessels from preexisting vessels. In the present study, we evaluated the effects of diamond and graphite nanoparticles on the development of chicken embryos, as well as vascularization of the chorioallantoic membrane and heart at the morphological and molecular level. Nanoparticles did not affect either body/heart weight or serum indices of the embryos’ health. However, vascularization of the heart and the density of branched vessels were significantly reduced after treatment with diamond nanoparticles and, to a lesser extent, graphite nanoparticles. Application of nanoparticles significantly downregulated gene and protein expression of the proangiogenic basic fibroblast growth factor, indicating that both diamond and graphite nanoparticles inhibit angiogenesis. Keywords: diamond, graphite, nanoparticles, vasculogenesis, bFGF, VEGFWierzbicki MSawosz EGrodzik MHotowy APrasek MJaworski SSawosz FChwalibog ADove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 3427-3435 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Wierzbicki M Sawosz E Grodzik M Hotowy A Prasek M Jaworski S Sawosz F Chwalibog A Carbon nanoparticles downregulate expression of basic fibroblast growth factor in the heart during embryogenesis
description	Mateusz Wierzbicki,1 Ewa Sawosz,1 Marta Grodzik,1 Anna Hotowy,1 Marta Prasek,1 Slawomir Jaworski,1 Filip Sawosz,2 André Chwalibog2 1Division of Nanobiotechnology, Warsaw University of Life Sciences, Warsaw, Poland; 2Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, Copenhagen, Denmark Abstract: Carbon nanoparticles, with their high biocompatibility and low toxicity, have recently been considered for biomedical applications, including antiangiogenic therapy. Critical to normal development and tumor formation, angiogenesis is the process of forming capillary blood vessels from preexisting vessels. In the present study, we evaluated the effects of diamond and graphite nanoparticles on the development of chicken embryos, as well as vascularization of the chorioallantoic membrane and heart at the morphological and molecular level. Nanoparticles did not affect either body/heart weight or serum indices of the embryos’ health. However, vascularization of the heart and the density of branched vessels were significantly reduced after treatment with diamond nanoparticles and, to a lesser extent, graphite nanoparticles. Application of nanoparticles significantly downregulated gene and protein expression of the proangiogenic basic fibroblast growth factor, indicating that both diamond and graphite nanoparticles inhibit angiogenesis. Keywords: diamond, graphite, nanoparticles, vasculogenesis, bFGF, VEGF
format	article
author	Wierzbicki M Sawosz E Grodzik M Hotowy A Prasek M Jaworski S Sawosz F Chwalibog A
author_facet	Wierzbicki M Sawosz E Grodzik M Hotowy A Prasek M Jaworski S Sawosz F Chwalibog A
author_sort	Wierzbicki M
title	Carbon nanoparticles downregulate expression of basic fibroblast growth factor in the heart during embryogenesis
title_short	Carbon nanoparticles downregulate expression of basic fibroblast growth factor in the heart during embryogenesis
title_full	Carbon nanoparticles downregulate expression of basic fibroblast growth factor in the heart during embryogenesis
title_fullStr	Carbon nanoparticles downregulate expression of basic fibroblast growth factor in the heart during embryogenesis
title_full_unstemmed	Carbon nanoparticles downregulate expression of basic fibroblast growth factor in the heart during embryogenesis
title_sort	carbon nanoparticles downregulate expression of basic fibroblast growth factor in the heart during embryogenesis
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/a69deeaaeb704702936894752e5325dd
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Carbon nanoparticles downregulate expression of basic fibroblast growth factor in the heart during embryogenesis

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