Relationship between total cholesterol level and tuberculosis risk in a nationwide longitudinal cohort

Abstract The association between the total cholesterol level and tuberculosis (TB) risk has been controversial. Our study aimed to evaluate whether total cholesterol level can predict the risk of TB. Data from 5,000,566 subjects who participated in a health screening exam in 2009 were investigated u...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Yong Suk Jo, Kyungdo Han, Dahye Kim, Jung Eun Yoo, Yuji Kim, Bumhee Yang, Hayoung Choi, Jang Won Sohn, Dong Wook Shin, Hyun Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
R
Q
Acceso en línea:https://doaj.org/article/a6a6ffedeed74a69a2017f54428f9d9b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:a6a6ffedeed74a69a2017f54428f9d9b
record_format dspace
spelling oai:doaj.org-article:a6a6ffedeed74a69a2017f54428f9d9b2021-12-02T18:50:49ZRelationship between total cholesterol level and tuberculosis risk in a nationwide longitudinal cohort10.1038/s41598-021-95704-12045-2322https://doaj.org/article/a6a6ffedeed74a69a2017f54428f9d9b2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95704-1https://doaj.org/toc/2045-2322Abstract The association between the total cholesterol level and tuberculosis (TB) risk has been controversial. Our study aimed to evaluate whether total cholesterol level can predict the risk of TB. Data from 5,000,566 subjects who participated in a health screening exam in 2009 were investigated using the Korean National Health Insurance Service database (2009–2018). Cox hazard regression analyses were used to evaluate TB risk according to the quartile of total cholesterol levels. During an average of 8.2 years of follow-up, 32,078 cases of TB occurred. There was a significant inverse association between the total cholesterol level and TB risk. Compared with subjects in the highest quartile, those in the lowest quartile had a 1.35-fold increased TB risk (95% confidence interval = 1.31–1.39). The association between total cholesterol level and TB risk was more apparent in young subjects (age < 65 years), those without diabetes mellitus (DM), and those without obesity (p for interaction < 0.001 for age group, DM, and body mass index). Although there was a significant inverse association between total cholesterol level and TB risk in subjects who did not use a statin, no significant association was observed between the total cholesterol level and TB risk in subjects who used a statin. A low total cholesterol level was significantly associated with an increased risk of TB, even after adjusting for confounders, especially in patients younger than 65 years, those without DM or obesity, and those who did not use a statin.Yong Suk JoKyungdo HanDahye KimJung Eun YooYuji KimBumhee YangHayoung ChoiJang Won SohnDong Wook ShinHyun LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Yong Suk Jo
Kyungdo Han
Dahye Kim
Jung Eun Yoo
Yuji Kim
Bumhee Yang
Hayoung Choi
Jang Won Sohn
Dong Wook Shin
Hyun Lee
Relationship between total cholesterol level and tuberculosis risk in a nationwide longitudinal cohort
description Abstract The association between the total cholesterol level and tuberculosis (TB) risk has been controversial. Our study aimed to evaluate whether total cholesterol level can predict the risk of TB. Data from 5,000,566 subjects who participated in a health screening exam in 2009 were investigated using the Korean National Health Insurance Service database (2009–2018). Cox hazard regression analyses were used to evaluate TB risk according to the quartile of total cholesterol levels. During an average of 8.2 years of follow-up, 32,078 cases of TB occurred. There was a significant inverse association between the total cholesterol level and TB risk. Compared with subjects in the highest quartile, those in the lowest quartile had a 1.35-fold increased TB risk (95% confidence interval = 1.31–1.39). The association between total cholesterol level and TB risk was more apparent in young subjects (age < 65 years), those without diabetes mellitus (DM), and those without obesity (p for interaction < 0.001 for age group, DM, and body mass index). Although there was a significant inverse association between total cholesterol level and TB risk in subjects who did not use a statin, no significant association was observed between the total cholesterol level and TB risk in subjects who used a statin. A low total cholesterol level was significantly associated with an increased risk of TB, even after adjusting for confounders, especially in patients younger than 65 years, those without DM or obesity, and those who did not use a statin.
format article
author Yong Suk Jo
Kyungdo Han
Dahye Kim
Jung Eun Yoo
Yuji Kim
Bumhee Yang
Hayoung Choi
Jang Won Sohn
Dong Wook Shin
Hyun Lee
author_facet Yong Suk Jo
Kyungdo Han
Dahye Kim
Jung Eun Yoo
Yuji Kim
Bumhee Yang
Hayoung Choi
Jang Won Sohn
Dong Wook Shin
Hyun Lee
author_sort Yong Suk Jo
title Relationship between total cholesterol level and tuberculosis risk in a nationwide longitudinal cohort
title_short Relationship between total cholesterol level and tuberculosis risk in a nationwide longitudinal cohort
title_full Relationship between total cholesterol level and tuberculosis risk in a nationwide longitudinal cohort
title_fullStr Relationship between total cholesterol level and tuberculosis risk in a nationwide longitudinal cohort
title_full_unstemmed Relationship between total cholesterol level and tuberculosis risk in a nationwide longitudinal cohort
title_sort relationship between total cholesterol level and tuberculosis risk in a nationwide longitudinal cohort
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/a6a6ffedeed74a69a2017f54428f9d9b
work_keys_str_mv AT yongsukjo relationshipbetweentotalcholesterollevelandtuberculosisriskinanationwidelongitudinalcohort
AT kyungdohan relationshipbetweentotalcholesterollevelandtuberculosisriskinanationwidelongitudinalcohort
AT dahyekim relationshipbetweentotalcholesterollevelandtuberculosisriskinanationwidelongitudinalcohort
AT jungeunyoo relationshipbetweentotalcholesterollevelandtuberculosisriskinanationwidelongitudinalcohort
AT yujikim relationshipbetweentotalcholesterollevelandtuberculosisriskinanationwidelongitudinalcohort
AT bumheeyang relationshipbetweentotalcholesterollevelandtuberculosisriskinanationwidelongitudinalcohort
AT hayoungchoi relationshipbetweentotalcholesterollevelandtuberculosisriskinanationwidelongitudinalcohort
AT jangwonsohn relationshipbetweentotalcholesterollevelandtuberculosisriskinanationwidelongitudinalcohort
AT dongwookshin relationshipbetweentotalcholesterollevelandtuberculosisriskinanationwidelongitudinalcohort
AT hyunlee relationshipbetweentotalcholesterollevelandtuberculosisriskinanationwidelongitudinalcohort
_version_ 1718377523607240704