Regular exercise participation improves genomic stability in diabetic patients: an exploratory study to analyse telomere length and DNA damage

Abstract Physical activity has been demonstrated to be effective in the prevention and treatment of different chronic conditions, including type 2 diabetes (T2D). In particular, several studies highlighted how the beneficial effects of physical activity may be related to the stability of the DNA mol...

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Autores principales:	Ivan Dimauro, Antonella Sgura, Monica Pittaluga, Fiorenza Magi, Cristina Fantini, Rosa Mancinelli, Antonio Sgadari, Stefania Fulle, Daniela Caporossi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a6a8b9c120cd4b9dbb6955488c9fd42a
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spelling	oai:doaj.org-article:a6a8b9c120cd4b9dbb6955488c9fd42a2021-12-02T11:40:33ZRegular exercise participation improves genomic stability in diabetic patients: an exploratory study to analyse telomere length and DNA damage10.1038/s41598-017-04448-42045-2322https://doaj.org/article/a6a8b9c120cd4b9dbb6955488c9fd42a2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04448-4https://doaj.org/toc/2045-2322Abstract Physical activity has been demonstrated to be effective in the prevention and treatment of different chronic conditions, including type 2 diabetes (T2D). In particular, several studies highlighted how the beneficial effects of physical activity may be related to the stability of the DNA molecule, such as longer telomeric ends. Here we analyze the effect of exercise training on telomere length, spontaneous and H2O2-induced DNA damage, as well as the apoptosis level in leukocytes from untrained or trained T2D patients vs. age-matched control subjects (CS) (57–66 years). Moreover, expression analysis of selected genes belonging to DNA repair systems, cell cycle control, antioxidant and defence systems was performed. Subjects that participated in a regular exercise program showed a longer telomere sequence than untrained counterparts. Moreover, ex vivo treatment of leukocytes with H2O2 highlighted that: (1) oxidative DNA damage induced similar telomere attrition in all groups; (2) in T2D subjects, physical activity seemed to prevent a significant increase of genomic oxidative DNA damage induced by chronic exposure to pro-oxidant stimulus, and (3) decreased the sensitivity of leukocytes to apoptosis. Finally, the gene expression analysis in T2D subjects suggested an adaptive response to prolonged exercise training that improved the response of specific genes.Ivan DimauroAntonella SguraMonica PittalugaFiorenza MagiCristina FantiniRosa MancinelliAntonio SgadariStefania FulleDaniela CaporossiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ivan Dimauro Antonella Sgura Monica Pittaluga Fiorenza Magi Cristina Fantini Rosa Mancinelli Antonio Sgadari Stefania Fulle Daniela Caporossi Regular exercise participation improves genomic stability in diabetic patients: an exploratory study to analyse telomere length and DNA damage
description	Abstract Physical activity has been demonstrated to be effective in the prevention and treatment of different chronic conditions, including type 2 diabetes (T2D). In particular, several studies highlighted how the beneficial effects of physical activity may be related to the stability of the DNA molecule, such as longer telomeric ends. Here we analyze the effect of exercise training on telomere length, spontaneous and H2O2-induced DNA damage, as well as the apoptosis level in leukocytes from untrained or trained T2D patients vs. age-matched control subjects (CS) (57–66 years). Moreover, expression analysis of selected genes belonging to DNA repair systems, cell cycle control, antioxidant and defence systems was performed. Subjects that participated in a regular exercise program showed a longer telomere sequence than untrained counterparts. Moreover, ex vivo treatment of leukocytes with H2O2 highlighted that: (1) oxidative DNA damage induced similar telomere attrition in all groups; (2) in T2D subjects, physical activity seemed to prevent a significant increase of genomic oxidative DNA damage induced by chronic exposure to pro-oxidant stimulus, and (3) decreased the sensitivity of leukocytes to apoptosis. Finally, the gene expression analysis in T2D subjects suggested an adaptive response to prolonged exercise training that improved the response of specific genes.
format	article
author	Ivan Dimauro Antonella Sgura Monica Pittaluga Fiorenza Magi Cristina Fantini Rosa Mancinelli Antonio Sgadari Stefania Fulle Daniela Caporossi
author_facet	Ivan Dimauro Antonella Sgura Monica Pittaluga Fiorenza Magi Cristina Fantini Rosa Mancinelli Antonio Sgadari Stefania Fulle Daniela Caporossi
author_sort	Ivan Dimauro
title	Regular exercise participation improves genomic stability in diabetic patients: an exploratory study to analyse telomere length and DNA damage
title_short	Regular exercise participation improves genomic stability in diabetic patients: an exploratory study to analyse telomere length and DNA damage
title_full	Regular exercise participation improves genomic stability in diabetic patients: an exploratory study to analyse telomere length and DNA damage
title_fullStr	Regular exercise participation improves genomic stability in diabetic patients: an exploratory study to analyse telomere length and DNA damage
title_full_unstemmed	Regular exercise participation improves genomic stability in diabetic patients: an exploratory study to analyse telomere length and DNA damage
title_sort	regular exercise participation improves genomic stability in diabetic patients: an exploratory study to analyse telomere length and dna damage
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a6a8b9c120cd4b9dbb6955488c9fd42a
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Regular exercise participation improves genomic stability in diabetic patients: an exploratory study to analyse telomere length and DNA damage

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