Novel application of trimethyl chitosan as an adjuvant in vaccine delivery

Anshu Malik,* Manish Gupta,* Vatika Gupta, Himanshu Gogoi, Rakesh Bhatnagar Molecular Biology and Genetic Engineering Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India *These authors contributed equally to this work Abstract: The application of natural carbohydrat...

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Autores principales:	Malik A, Gupta M, Gupta V, Gogoi H, Bhatnagar R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Trimethyl chitosan Chitosan Vaccine delivery Adjuvant. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a6a940deca074024b3e02bd4f251b3c3
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spelling	oai:doaj.org-article:a6a940deca074024b3e02bd4f251b3c32021-12-02T00:39:22ZNovel application of trimethyl chitosan as an adjuvant in vaccine delivery1178-2013https://doaj.org/article/a6a940deca074024b3e02bd4f251b3c32018-11-01T00:00:00Zhttps://www.dovepress.com/novel-application-of-trimethyl-chitosan-as-an-adjuvant-in-vaccine-deli-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Anshu Malik,* Manish Gupta,* Vatika Gupta, Himanshu Gogoi, Rakesh Bhatnagar Molecular Biology and Genetic Engineering Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India *These authors contributed equally to this work Abstract: The application of natural carbohydrate polysaccharides for antigen delivery and its adjuvanation potential has garnered interest in the scientific community in the recent years. These biomaterials are considered favorable candidates for adjuvant development due to their desirable properties like enormous bioavailability, non-toxicity, biodegradability, stability, affordability, and immunostimulating ability. Chitosan is the one such extensively studied natural polymer which has been appreciated for its excellent applications in pharmaceuticals. Trimethyl chitosan (TMC), a derivative of chitosan, possesses these properties. In addition it has the properties of high aqueous solubility, high charge density, mucoadhesive, permeation enhancing (ability to cross tight junction), and stability over a range of ionic conditions which makes the spectrum of its applicability much broader. It has also been seen to perform analogously to alum, complete Freund’s adjuvant, incomplete Freund’s adjuvant, and cyclic guanosine monophosphate adjuvanation, which justifies its role as a potent adjuvant. Although many review articles detailing the applications of chitosan in vaccine delivery are available, a comprehensive review of the applications of TMC as an adjuvant is not available to date. This article provides a comprehensive overview of structural and chemical properties of TMC which affect its adjuvant characteristics; the efficacy of various delivery routes for TMC antigen combination; and the recent advances in the elucidation of its mechanism of action. Keywords: trimethyl chitosan, chitosan, vaccine delivery, adjuvant, polymerMalik AGupta MGupta VGogoi HBhatnagar RDove Medical PressarticleTrimethyl chitosanChitosanVaccine deliveryAdjuvant.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 7959-7970 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Trimethyl chitosan Chitosan Vaccine delivery Adjuvant. Medicine (General) R5-920
spellingShingle	Trimethyl chitosan Chitosan Vaccine delivery Adjuvant. Medicine (General) R5-920 Malik A Gupta M Gupta V Gogoi H Bhatnagar R Novel application of trimethyl chitosan as an adjuvant in vaccine delivery
description	Anshu Malik,* Manish Gupta,* Vatika Gupta, Himanshu Gogoi, Rakesh Bhatnagar Molecular Biology and Genetic Engineering Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India *These authors contributed equally to this work Abstract: The application of natural carbohydrate polysaccharides for antigen delivery and its adjuvanation potential has garnered interest in the scientific community in the recent years. These biomaterials are considered favorable candidates for adjuvant development due to their desirable properties like enormous bioavailability, non-toxicity, biodegradability, stability, affordability, and immunostimulating ability. Chitosan is the one such extensively studied natural polymer which has been appreciated for its excellent applications in pharmaceuticals. Trimethyl chitosan (TMC), a derivative of chitosan, possesses these properties. In addition it has the properties of high aqueous solubility, high charge density, mucoadhesive, permeation enhancing (ability to cross tight junction), and stability over a range of ionic conditions which makes the spectrum of its applicability much broader. It has also been seen to perform analogously to alum, complete Freund’s adjuvant, incomplete Freund’s adjuvant, and cyclic guanosine monophosphate adjuvanation, which justifies its role as a potent adjuvant. Although many review articles detailing the applications of chitosan in vaccine delivery are available, a comprehensive review of the applications of TMC as an adjuvant is not available to date. This article provides a comprehensive overview of structural and chemical properties of TMC which affect its adjuvant characteristics; the efficacy of various delivery routes for TMC antigen combination; and the recent advances in the elucidation of its mechanism of action. Keywords: trimethyl chitosan, chitosan, vaccine delivery, adjuvant, polymer
format	article
author	Malik A Gupta M Gupta V Gogoi H Bhatnagar R
author_facet	Malik A Gupta M Gupta V Gogoi H Bhatnagar R
author_sort	Malik A
title	Novel application of trimethyl chitosan as an adjuvant in vaccine delivery
title_short	Novel application of trimethyl chitosan as an adjuvant in vaccine delivery
title_full	Novel application of trimethyl chitosan as an adjuvant in vaccine delivery
title_fullStr	Novel application of trimethyl chitosan as an adjuvant in vaccine delivery
title_full_unstemmed	Novel application of trimethyl chitosan as an adjuvant in vaccine delivery
title_sort	novel application of trimethyl chitosan as an adjuvant in vaccine delivery
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/a6a940deca074024b3e02bd4f251b3c3
work_keys_str_mv	AT malika novelapplicationoftrimethylchitosanasanadjuvantinvaccinedelivery AT guptam novelapplicationoftrimethylchitosanasanadjuvantinvaccinedelivery AT guptav novelapplicationoftrimethylchitosanasanadjuvantinvaccinedelivery AT gogoih novelapplicationoftrimethylchitosanasanadjuvantinvaccinedelivery AT bhatnagarr novelapplicationoftrimethylchitosanasanadjuvantinvaccinedelivery
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Novel application of trimethyl chitosan as an adjuvant in vaccine delivery

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