Thyroid hormone activated upper gastrointestinal motility without mediating gastrointestinal hormones in conscious dogs
Abstract This study was conducted to clarify the relationship between thyroid function and gastrointestinal motility. We established an experimental configuration in which the feedback of thyroid function was completely removed using conscious dogs. With hypothyroidism, time of phase I of interdiges...
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Nature Portfolio
2021
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oai:doaj.org-article:a6a9c7d6e13e42b7bdfb416e181c82ad2021-12-02T17:02:21ZThyroid hormone activated upper gastrointestinal motility without mediating gastrointestinal hormones in conscious dogs10.1038/s41598-021-89378-y2045-2322https://doaj.org/article/a6a9c7d6e13e42b7bdfb416e181c82ad2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89378-yhttps://doaj.org/toc/2045-2322Abstract This study was conducted to clarify the relationship between thyroid function and gastrointestinal motility. We established an experimental configuration in which the feedback of thyroid function was completely removed using conscious dogs. With hypothyroidism, time of phase I of interdigestive migrating contractions (IMC) was longer, time of phase II and phase III was significantly shortened, and both the continuous time of strong tetanic contraction at antrum and 10-h frequency of phase III counted from the first IMC after meal significantly decreased. Whereas, hyperthyroidism caused the opposite events to those with hypothyroidism. Furthermore, We found giant migrating contractions (GMC) occurred from the upper gastrointestinal tract when we administrated high dose of thyroid hormone. One GMC occurred from anal sides propagated to cardiac, and this propagation was similar to the emesis-like interdigestive motor activity, the other GMC occurred from oral sides propagated to anal sides and this was similar to the diarrhea-like interdigestive motor activity. We examined the relationship between thyroid function and gastrointestinal hormones including of ghrelin, GLP-1, and cholecystokinin (CCK). However, we could not find significant differences under different thyroid hormone status. This is the first report that thyroid hormone activated upper gastrointestinal motility without mediating gastrointestinal hormones.Nobuhiro NakazawaMakoto SohdaKyoichi OgataSeded BaatarYasunari UbukataKengo KuriyamaKeigo HaraMasaki SuzukiToru YanomaAkiharu KimuraNorimichi KogureAkihiko SanoMakoto SakaiTakehiko YokoboriAtsushi OueErito MochikiHiroyuki KuwanoKen ShirabeNoriyuki KoibuchiHiroshi SaekiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Nobuhiro Nakazawa Makoto Sohda Kyoichi Ogata Seded Baatar Yasunari Ubukata Kengo Kuriyama Keigo Hara Masaki Suzuki Toru Yanoma Akiharu Kimura Norimichi Kogure Akihiko Sano Makoto Sakai Takehiko Yokobori Atsushi Oue Erito Mochiki Hiroyuki Kuwano Ken Shirabe Noriyuki Koibuchi Hiroshi Saeki Thyroid hormone activated upper gastrointestinal motility without mediating gastrointestinal hormones in conscious dogs |
| description |
Abstract This study was conducted to clarify the relationship between thyroid function and gastrointestinal motility. We established an experimental configuration in which the feedback of thyroid function was completely removed using conscious dogs. With hypothyroidism, time of phase I of interdigestive migrating contractions (IMC) was longer, time of phase II and phase III was significantly shortened, and both the continuous time of strong tetanic contraction at antrum and 10-h frequency of phase III counted from the first IMC after meal significantly decreased. Whereas, hyperthyroidism caused the opposite events to those with hypothyroidism. Furthermore, We found giant migrating contractions (GMC) occurred from the upper gastrointestinal tract when we administrated high dose of thyroid hormone. One GMC occurred from anal sides propagated to cardiac, and this propagation was similar to the emesis-like interdigestive motor activity, the other GMC occurred from oral sides propagated to anal sides and this was similar to the diarrhea-like interdigestive motor activity. We examined the relationship between thyroid function and gastrointestinal hormones including of ghrelin, GLP-1, and cholecystokinin (CCK). However, we could not find significant differences under different thyroid hormone status. This is the first report that thyroid hormone activated upper gastrointestinal motility without mediating gastrointestinal hormones. |
| format |
article |
| author |
Nobuhiro Nakazawa Makoto Sohda Kyoichi Ogata Seded Baatar Yasunari Ubukata Kengo Kuriyama Keigo Hara Masaki Suzuki Toru Yanoma Akiharu Kimura Norimichi Kogure Akihiko Sano Makoto Sakai Takehiko Yokobori Atsushi Oue Erito Mochiki Hiroyuki Kuwano Ken Shirabe Noriyuki Koibuchi Hiroshi Saeki |
| author_facet |
Nobuhiro Nakazawa Makoto Sohda Kyoichi Ogata Seded Baatar Yasunari Ubukata Kengo Kuriyama Keigo Hara Masaki Suzuki Toru Yanoma Akiharu Kimura Norimichi Kogure Akihiko Sano Makoto Sakai Takehiko Yokobori Atsushi Oue Erito Mochiki Hiroyuki Kuwano Ken Shirabe Noriyuki Koibuchi Hiroshi Saeki |
| author_sort |
Nobuhiro Nakazawa |
| title |
Thyroid hormone activated upper gastrointestinal motility without mediating gastrointestinal hormones in conscious dogs |
| title_short |
Thyroid hormone activated upper gastrointestinal motility without mediating gastrointestinal hormones in conscious dogs |
| title_full |
Thyroid hormone activated upper gastrointestinal motility without mediating gastrointestinal hormones in conscious dogs |
| title_fullStr |
Thyroid hormone activated upper gastrointestinal motility without mediating gastrointestinal hormones in conscious dogs |
| title_full_unstemmed |
Thyroid hormone activated upper gastrointestinal motility without mediating gastrointestinal hormones in conscious dogs |
| title_sort |
thyroid hormone activated upper gastrointestinal motility without mediating gastrointestinal hormones in conscious dogs |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/a6a9c7d6e13e42b7bdfb416e181c82ad |
| work_keys_str_mv |
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