Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits

The identification of the causal gene at a GWAS locus remains to be a challenging task. Here, using the SMR & HEIDI method to integrate GWAS, eQTL and mQTL data, Wu et al. map DNA methylation sites to the transcriptome and thereby prioritize functionally relevant genes for 12 human complex trait...

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Autores principales:	Yang Wu, Jian Zeng, Futao Zhang, Zhihong Zhu, Ting Qi, Zhili Zheng, Luke R. Lloyd-Jones, Riccardo E. Marioni, Nicholas G. Martin, Grant W. Montgomery, Ian J. Deary, Naomi R. Wray, Peter M. Visscher, Allan F. McRae, Jian Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a6ab9fc5f7564113952bcd84f4a08d3e
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spelling	oai:doaj.org-article:a6ab9fc5f7564113952bcd84f4a08d3e2021-12-02T15:33:57ZIntegrative analysis of omics summary data reveals putative mechanisms underlying complex traits10.1038/s41467-018-03371-02041-1723https://doaj.org/article/a6ab9fc5f7564113952bcd84f4a08d3e2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03371-0https://doaj.org/toc/2041-1723The identification of the causal gene at a GWAS locus remains to be a challenging task. Here, using the SMR & HEIDI method to integrate GWAS, eQTL and mQTL data, Wu et al. map DNA methylation sites to the transcriptome and thereby prioritize functionally relevant genes for 12 human complex traits.Yang WuJian ZengFutao ZhangZhihong ZhuTing QiZhili ZhengLuke R. Lloyd-JonesRiccardo E. MarioniNicholas G. MartinGrant W. MontgomeryIan J. DearyNaomi R. WrayPeter M. VisscherAllan F. McRaeJian YangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yang Wu Jian Zeng Futao Zhang Zhihong Zhu Ting Qi Zhili Zheng Luke R. Lloyd-Jones Riccardo E. Marioni Nicholas G. Martin Grant W. Montgomery Ian J. Deary Naomi R. Wray Peter M. Visscher Allan F. McRae Jian Yang Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits
description	The identification of the causal gene at a GWAS locus remains to be a challenging task. Here, using the SMR & HEIDI method to integrate GWAS, eQTL and mQTL data, Wu et al. map DNA methylation sites to the transcriptome and thereby prioritize functionally relevant genes for 12 human complex traits.
format	article
author	Yang Wu Jian Zeng Futao Zhang Zhihong Zhu Ting Qi Zhili Zheng Luke R. Lloyd-Jones Riccardo E. Marioni Nicholas G. Martin Grant W. Montgomery Ian J. Deary Naomi R. Wray Peter M. Visscher Allan F. McRae Jian Yang
author_facet	Yang Wu Jian Zeng Futao Zhang Zhihong Zhu Ting Qi Zhili Zheng Luke R. Lloyd-Jones Riccardo E. Marioni Nicholas G. Martin Grant W. Montgomery Ian J. Deary Naomi R. Wray Peter M. Visscher Allan F. McRae Jian Yang
author_sort	Yang Wu
title	Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits
title_short	Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits
title_full	Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits
title_fullStr	Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits
title_full_unstemmed	Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits
title_sort	integrative analysis of omics summary data reveals putative mechanisms underlying complex traits
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a6ab9fc5f7564113952bcd84f4a08d3e
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Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits

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