Psychobiology and candidate endophenotypes in psychopathy

At present there exist a lot of neurobiological and molecular studies that suggest genetic susceptibility to different characteristics of the expression of psychopathy; nevertheless, so far much of those results have not successfully and consistently been replicated, mainly because of the difficulti...

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Autor principal:	Jorge Mauricio Cuartas Arias
Formato:	article
Lenguaje:	EN ES
Publicado:	Universidad de San Buenaventura 2011
Materias:	Psychopathy cognitive endophenotypes antisocial personality psychobiology Psychology BF1-990
Acceso en línea:	https://doaj.org/article/a6ac0c8763f948ada629b7fb955293a8
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spelling	oai:doaj.org-article:a6ac0c8763f948ada629b7fb955293a82021-11-25T02:23:40ZPsychobiology and candidate endophenotypes in psychopathy10.21500/20112084.8042011-20842011-7922https://doaj.org/article/a6ac0c8763f948ada629b7fb955293a82011-06-01T00:00:00Zhttps://revistas.usb.edu.co/index.php/IJPR/article/view/804https://doaj.org/toc/2011-2084https://doaj.org/toc/2011-7922At present there exist a lot of neurobiological and molecular studies that suggest genetic susceptibility to different characteristics of the expression of psychopathy; nevertheless, so far much of those results have not successfully and consistently been replicated, mainly because of the difficulties in: sensitivity, specificity and validity of the clinical evaluation methods; the size and type of the chosen population; and the experimental designs used. Unfortunately, the diagnoses in psychiatry and psychology uses a classification based on prevalence and intensity of the symptoms and do not taken into account the etiology, neurobiology, epidemiology, genetics and response to medication. The use of limited diagnostic tools analysis and dichotomized the clinical diagnoses lead to a loss of power in the validation of the phenotype being studied and the lack of neurobiological knowledge of the molecules implicated in this kind of disorders, increasing the genetic heterogeneity. This condition obstructs the mapping of susceptibility genes which might outline the neurobiology and pathophysiology of the disease as a central scheme in the conceptualization of the syndrome. This article, we present the most appropriate strategies for examining the phenotype of psychopathy through the use of endophenotypes.Jorge Mauricio Cuartas AriasUniversidad de San BuenaventuraarticlePsychopathycognitive endophenotypesantisocial personalitypsychobiologyPsychologyBF1-990ENESInternational Journal of Psychological Research, Vol 4, Iss 1 (2011)
institution	DOAJ
collection	DOAJ
language	EN ES
topic	Psychopathy cognitive endophenotypes antisocial personality psychobiology Psychology BF1-990
spellingShingle	Psychopathy cognitive endophenotypes antisocial personality psychobiology Psychology BF1-990 Jorge Mauricio Cuartas Arias Psychobiology and candidate endophenotypes in psychopathy
description	At present there exist a lot of neurobiological and molecular studies that suggest genetic susceptibility to different characteristics of the expression of psychopathy; nevertheless, so far much of those results have not successfully and consistently been replicated, mainly because of the difficulties in: sensitivity, specificity and validity of the clinical evaluation methods; the size and type of the chosen population; and the experimental designs used. Unfortunately, the diagnoses in psychiatry and psychology uses a classification based on prevalence and intensity of the symptoms and do not taken into account the etiology, neurobiology, epidemiology, genetics and response to medication. The use of limited diagnostic tools analysis and dichotomized the clinical diagnoses lead to a loss of power in the validation of the phenotype being studied and the lack of neurobiological knowledge of the molecules implicated in this kind of disorders, increasing the genetic heterogeneity. This condition obstructs the mapping of susceptibility genes which might outline the neurobiology and pathophysiology of the disease as a central scheme in the conceptualization of the syndrome. This article, we present the most appropriate strategies for examining the phenotype of psychopathy through the use of endophenotypes.
format	article
author	Jorge Mauricio Cuartas Arias
author_facet	Jorge Mauricio Cuartas Arias
author_sort	Jorge Mauricio Cuartas Arias
title	Psychobiology and candidate endophenotypes in psychopathy
title_short	Psychobiology and candidate endophenotypes in psychopathy
title_full	Psychobiology and candidate endophenotypes in psychopathy
title_fullStr	Psychobiology and candidate endophenotypes in psychopathy
title_full_unstemmed	Psychobiology and candidate endophenotypes in psychopathy
title_sort	psychobiology and candidate endophenotypes in psychopathy
publisher	Universidad de San Buenaventura
publishDate	2011
url	https://doaj.org/article/a6ac0c8763f948ada629b7fb955293a8
work_keys_str_mv	AT jorgemauriciocuartasarias psychobiologyandcandidateendophenotypesinpsychopathy
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Psychobiology and candidate endophenotypes in psychopathy

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