Microfluidic high-throughput single-cell mechanotyping: Devices and applications
The mechanical behavior of individual cells plays an important role in regulating various biological activities at the molecular and cellular levels. It can serve as a promising label-free marker of cells’ physiological states. In the past two decades, several technique...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
AIP Publishing LLC
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/a6af85a13a644cbaaca524b3a447114f |
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| Sumario: | The mechanical behavior of individual cells plays an important role in regulating various
biological activities at the molecular and cellular levels. It can serve as a promising
label-free marker of cells’ physiological states. In the past two decades, several
techniques have been developed for understanding correlations between cellular mechanical
changes and human diseases. However, numerous technical challenges remain with regard to
realizing high-throughput, robust, and easy-to-perform measurements of single-cell
mechanical properties. In this paper, we review the emerging tools for single-cell
mechanical characterization that are provided by microfluidic technology. Different
techniques are benchmarked by considering their advantages and limitations. Finally, the
potential applications of microfluidic techniques based on cellular mechanical properties
are discussed. |
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