Microfluidic high-throughput single-cell mechanotyping: Devices and applications

The mechanical behavior of individual cells plays an important role in regulating various biological activities at the molecular and cellular levels. It can serve as a promising label-free marker of cells’ physiological states. In the past two decades, several technique...

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Autores principales:	Gihoon Choi, Zifan Tang, Weihua Guan
Formato:	article
Lenguaje:	EN
Publicado:	AIP Publishing LLC 2021
Materias:	Technology T Engineering (General). Civil engineering (General) TA1-2040
Acceso en línea:	https://doaj.org/article/a6af85a13a644cbaaca524b3a447114f
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spelling	oai:doaj.org-article:a6af85a13a644cbaaca524b3a447114f2021-12-01T18:51:51ZMicrofluidic high-throughput single-cell mechanotyping: Devices and applications2589-554010.1063/10.0006042https://doaj.org/article/a6af85a13a644cbaaca524b3a447114f2021-12-01T00:00:00Zhttp://dx.doi.org/10.1063/10.0006042https://doaj.org/toc/2589-5540The mechanical behavior of individual cells plays an important role in regulating various biological activities at the molecular and cellular levels. It can serve as a promising label-free marker of cells’ physiological states. In the past two decades, several techniques have been developed for understanding correlations between cellular mechanical changes and human diseases. However, numerous technical challenges remain with regard to realizing high-throughput, robust, and easy-to-perform measurements of single-cell mechanical properties. In this paper, we review the emerging tools for single-cell mechanical characterization that are provided by microfluidic technology. Different techniques are benchmarked by considering their advantages and limitations. Finally, the potential applications of microfluidic techniques based on cellular mechanical properties are discussed.Gihoon ChoiZifan TangWeihua GuanAIP Publishing LLCarticleTechnologyTEngineering (General). Civil engineering (General)TA1-2040ENNanotechnology and Precision Engineering, Vol 4, Iss 4, Pp 045002-045002-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Technology T Engineering (General). Civil engineering (General) TA1-2040
spellingShingle	Technology T Engineering (General). Civil engineering (General) TA1-2040 Gihoon Choi Zifan Tang Weihua Guan Microfluidic high-throughput single-cell mechanotyping: Devices and applications
description	The mechanical behavior of individual cells plays an important role in regulating various biological activities at the molecular and cellular levels. It can serve as a promising label-free marker of cells’ physiological states. In the past two decades, several techniques have been developed for understanding correlations between cellular mechanical changes and human diseases. However, numerous technical challenges remain with regard to realizing high-throughput, robust, and easy-to-perform measurements of single-cell mechanical properties. In this paper, we review the emerging tools for single-cell mechanical characterization that are provided by microfluidic technology. Different techniques are benchmarked by considering their advantages and limitations. Finally, the potential applications of microfluidic techniques based on cellular mechanical properties are discussed.
format	article
author	Gihoon Choi Zifan Tang Weihua Guan
author_facet	Gihoon Choi Zifan Tang Weihua Guan
author_sort	Gihoon Choi
title	Microfluidic high-throughput single-cell mechanotyping: Devices and applications
title_short	Microfluidic high-throughput single-cell mechanotyping: Devices and applications
title_full	Microfluidic high-throughput single-cell mechanotyping: Devices and applications
title_fullStr	Microfluidic high-throughput single-cell mechanotyping: Devices and applications
title_full_unstemmed	Microfluidic high-throughput single-cell mechanotyping: Devices and applications
title_sort	microfluidic high-throughput single-cell mechanotyping: devices and applications
publisher	AIP Publishing LLC
publishDate	2021
url	https://doaj.org/article/a6af85a13a644cbaaca524b3a447114f
work_keys_str_mv	AT gihoonchoi microfluidichighthroughputsinglecellmechanotypingdevicesandapplications AT zifantang microfluidichighthroughputsinglecellmechanotypingdevicesandapplications AT weihuaguan microfluidichighthroughputsinglecellmechanotypingdevicesandapplications
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Microfluidic high-throughput single-cell mechanotyping: Devices and applications

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