Aberrant Patterns of Sensory-Evoked Activity in the Olfactory Bulb of LRRK2 Knockout Mice

The LRRK2 gene is the major genetic determinant of familiar Parkinson’s disease (PD). Leucine-rich repeat kinase 2 (LRRK2) is a multidomain protein involved in several intracellular signaling pathways. A wealth of evidence indicates that LRRK2 is enriched at the presynaptic compartment where it regu...

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Autores principales:	Andrea Maset, Marco Albanesi, Antonio di Soccio, Martina Canova, Marco dal Maschio, Claudia Lodovichi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	LRRK2 olfactory alterations Parkinson’s disease Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a6afa2d072cb439bb754e429e07013c0
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spelling	oai:doaj.org-article:a6afa2d072cb439bb754e429e07013c02021-11-25T17:12:56ZAberrant Patterns of Sensory-Evoked Activity in the Olfactory Bulb of LRRK2 Knockout Mice10.3390/cells101132122073-4409https://doaj.org/article/a6afa2d072cb439bb754e429e07013c02021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3212https://doaj.org/toc/2073-4409The LRRK2 gene is the major genetic determinant of familiar Parkinson’s disease (PD). Leucine-rich repeat kinase 2 (LRRK2) is a multidomain protein involved in several intracellular signaling pathways. A wealth of evidence indicates that LRRK2 is enriched at the presynaptic compartment where it regulates vesicle trafficking and neurotransmitter release. However, whether the role of LRRK2 affects neuronal networks dynamic at systems level remains unknown. Addressing this question is critical to unravel the impact of LRRK2 on brain function. Here, combining behavioral tests, electrophysiological recordings, and functional imaging, we investigated neuronal network dynamics, in vivo, in the olfactory bulb of mice carrying a null mutation in LRRK2 gene (LRRK2 knockout, LRRK2 KO, mice). We found that LRRK2 KO mice exhibit olfactory behavioral deficits. At the circuit level, the lack of LRRK2 expression results in altered gamma rhythms and odorant-evoked activity with significant impairments, while the spontaneous activity exhibited limited alterations. Overall, our data in the olfactory bulb suggest that the multifaced role of LRRK2 has a strong impact at system level when the network is engaged in active sensory processing.Andrea MasetMarco AlbanesiAntonio di SoccioMartina CanovaMarco dal MaschioClaudia LodovichiMDPI AGarticleLRRK2olfactory alterationsParkinson’s diseaseBiology (General)QH301-705.5ENCells, Vol 10, Iss 3212, p 3212 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	LRRK2 olfactory alterations Parkinson’s disease Biology (General) QH301-705.5
spellingShingle	LRRK2 olfactory alterations Parkinson’s disease Biology (General) QH301-705.5 Andrea Maset Marco Albanesi Antonio di Soccio Martina Canova Marco dal Maschio Claudia Lodovichi Aberrant Patterns of Sensory-Evoked Activity in the Olfactory Bulb of LRRK2 Knockout Mice
description	The LRRK2 gene is the major genetic determinant of familiar Parkinson’s disease (PD). Leucine-rich repeat kinase 2 (LRRK2) is a multidomain protein involved in several intracellular signaling pathways. A wealth of evidence indicates that LRRK2 is enriched at the presynaptic compartment where it regulates vesicle trafficking and neurotransmitter release. However, whether the role of LRRK2 affects neuronal networks dynamic at systems level remains unknown. Addressing this question is critical to unravel the impact of LRRK2 on brain function. Here, combining behavioral tests, electrophysiological recordings, and functional imaging, we investigated neuronal network dynamics, in vivo, in the olfactory bulb of mice carrying a null mutation in LRRK2 gene (LRRK2 knockout, LRRK2 KO, mice). We found that LRRK2 KO mice exhibit olfactory behavioral deficits. At the circuit level, the lack of LRRK2 expression results in altered gamma rhythms and odorant-evoked activity with significant impairments, while the spontaneous activity exhibited limited alterations. Overall, our data in the olfactory bulb suggest that the multifaced role of LRRK2 has a strong impact at system level when the network is engaged in active sensory processing.
format	article
author	Andrea Maset Marco Albanesi Antonio di Soccio Martina Canova Marco dal Maschio Claudia Lodovichi
author_facet	Andrea Maset Marco Albanesi Antonio di Soccio Martina Canova Marco dal Maschio Claudia Lodovichi
author_sort	Andrea Maset
title	Aberrant Patterns of Sensory-Evoked Activity in the Olfactory Bulb of LRRK2 Knockout Mice
title_short	Aberrant Patterns of Sensory-Evoked Activity in the Olfactory Bulb of LRRK2 Knockout Mice
title_full	Aberrant Patterns of Sensory-Evoked Activity in the Olfactory Bulb of LRRK2 Knockout Mice
title_fullStr	Aberrant Patterns of Sensory-Evoked Activity in the Olfactory Bulb of LRRK2 Knockout Mice
title_full_unstemmed	Aberrant Patterns of Sensory-Evoked Activity in the Olfactory Bulb of LRRK2 Knockout Mice
title_sort	aberrant patterns of sensory-evoked activity in the olfactory bulb of lrrk2 knockout mice
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a6afa2d072cb439bb754e429e07013c0
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Aberrant Patterns of Sensory-Evoked Activity in the Olfactory Bulb of LRRK2 Knockout Mice

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