A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy

A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy

Immune checkpoint blockade (ICB) immunotherapy efficacy has still limitations. Here, the authors generate a vaccine that integrates CD274 siRNA into the L1 protein of human papillomavirus, which cooperates with ICB by activating innate immunity in breast cancer models.

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Autores principales: Di-Wei Zheng, Fan Gao, Qian Cheng, Peng Bao, Xue Dong, Jin-Xuan Fan, Wen Song, Xuan Zeng, Si-Xue Cheng, Xian-Zheng Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/a6b06cb0091e4b669efd503940dbedac
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spelling oai:doaj.org-article:a6b06cb0091e4b669efd503940dbedac2021-12-02T14:40:28ZA vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy10.1038/s41467-020-15927-02041-1723https://doaj.org/article/a6b06cb0091e4b669efd503940dbedac2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15927-0https://doaj.org/toc/2041-1723Immune checkpoint blockade (ICB) immunotherapy efficacy has still limitations. Here, the authors generate a vaccine that integrates CD274 siRNA into the L1 protein of human papillomavirus, which cooperates with ICB by activating innate immunity in breast cancer models.Di-Wei ZhengFan GaoQian ChengPeng BaoXue DongJin-Xuan FanWen SongXuan ZengSi-Xue ChengXian-Zheng ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Di-Wei Zheng
Fan Gao
Qian Cheng
Peng Bao
Xue Dong
Jin-Xuan Fan
Wen Song
Xuan Zeng
Si-Xue Cheng
Xian-Zheng Zhang
A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy
description Immune checkpoint blockade (ICB) immunotherapy efficacy has still limitations. Here, the authors generate a vaccine that integrates CD274 siRNA into the L1 protein of human papillomavirus, which cooperates with ICB by activating innate immunity in breast cancer models.
format article
author Di-Wei Zheng
Fan Gao
Qian Cheng
Peng Bao
Xue Dong
Jin-Xuan Fan
Wen Song
Xuan Zeng
Si-Xue Cheng
Xian-Zheng Zhang
author_facet Di-Wei Zheng
Fan Gao
Qian Cheng
Peng Bao
Xue Dong
Jin-Xuan Fan
Wen Song
Xuan Zeng
Si-Xue Cheng
Xian-Zheng Zhang
author_sort Di-Wei Zheng
title A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy
title_short A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy
title_full A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy
title_fullStr A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy
title_full_unstemmed A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy
title_sort vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/a6b06cb0091e4b669efd503940dbedac
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