Association between CHA2DS2-VASc score and in-hospital death in ICU patients with COVID-19

Background: CHA2DS2-VASc score is a scientifically proven risk assessment score for patients with atrial fibrillation. It may be a good predictor of in-hospital death in COVID-19 patients. The present study aimed to evaluate the association between CHA2DS2-VASc score and in-hospital mortality in th...

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Autores principales:	Mukesh Jha, Utkarsh Mukesh Balani, Vimlesh Pandey, Prachi Balani, Vipin Patel, Abhishek Mehta
Formato:	article
Lenguaje:	EN
Publicado:	Journal of Ideas in Health 2021
Materias:	COVID-19, CHA2DS2-VASc, In-Hospital Death, Intensive Care Unit, SARS-CoV-2, India Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a6b3af84d6bf4947b78579a35f631f82
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spelling	oai:doaj.org-article:a6b3af84d6bf4947b78579a35f631f822021-11-24T12:41:50ZAssociation between CHA2DS2-VASc score and in-hospital death in ICU patients with COVID-1910.47108/jidhealth.Vol4.Iss4.1732645-9248https://doaj.org/article/a6b3af84d6bf4947b78579a35f631f822021-11-01T00:00:00Zhttps://www.jidhealth.com/index.php/jidhealth/article/view/173https://doaj.org/toc/2645-9248 Background: CHA2DS2-VASc score is a scientifically proven risk assessment score for patients with atrial fibrillation. It may be a good predictor of in-hospital death in COVID-19 patients. The present study aimed to evaluate the association between CHA2DS2-VASc score and in-hospital mortality in the prognosis of intensive care unit (ICU) patients with COVID-19. Methods: Eighty-four COVID-19 patients who were hospitalized in the ICU were retrospectively analyzed in a tertiary health care center, and the CHA2DS2-VASc score was determined. All analyses were performed using SPSS statistical software (SPSS Inc., Chicago, IL, USA, 20.0). A p-value <0.05 was considered statistically significant. Results: The median age of patients was 60.0 years, and most were males (75.0%). Findings of the study showed that the CHA2DS2-VASc score was considerably higher among the hospitalized patients than discharged patients (3.08 ± 1.72 vs. 1.38 ± 1.16; p<0.001), and patients who required mechanical ventilation compared to those who did not require mechanical ventilation (3.03 ± 1.68 vs. 1.15 ± 0.97; P <0.001), respectively. Patients with CHA2DS2-VASc score of ≥3 had substantially higher age [67(45-87) vs. 58(19-75); P ˂0.001], computed tomography involvement score [67.5(20-90) vs. 35(15-90); P ˂0.001] and need for mechanical ventilation [29(90.6%) vs. 22(42.3%); P ˂0.001]. A significant difference was found in oxygen saturation on admission (P =0.001) between the two groups. In-hospital death was significantly higher among patients with a CHA2DS2-VASc score of ≥3 (P <0.001). The CHA2DS2-VASc score was positively correlated with white blood cells count (r=0.257, P =0.018) and negatively correlated with the number of days spent in the hospital (r=-0.184, P=0.130) due to higher in-hospital death in ICU patients with COVID-19. Conclusion: CHA2DS2-VASc score may be an effective tool to estimate in-hospital death in COVID-19 patients who were hospitalized in the ICU. Mukesh JhaUtkarsh Mukesh BalaniVimlesh PandeyPrachi BalaniVipin PatelAbhishek MehtaJournal of Ideas in HealtharticleCOVID-19, CHA2DS2-VASc, In-Hospital Death, Intensive Care Unit, SARS-CoV-2, IndiaMedicineRMedicine (General)R5-920ENJournal of Ideas in Health, Vol 4, Iss 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19, CHA2DS2-VASc, In-Hospital Death, Intensive Care Unit, SARS-CoV-2, India Medicine R Medicine (General) R5-920
spellingShingle	COVID-19, CHA2DS2-VASc, In-Hospital Death, Intensive Care Unit, SARS-CoV-2, India Medicine R Medicine (General) R5-920 Mukesh Jha Utkarsh Mukesh Balani Vimlesh Pandey Prachi Balani Vipin Patel Abhishek Mehta Association between CHA2DS2-VASc score and in-hospital death in ICU patients with COVID-19
description	Background: CHA2DS2-VASc score is a scientifically proven risk assessment score for patients with atrial fibrillation. It may be a good predictor of in-hospital death in COVID-19 patients. The present study aimed to evaluate the association between CHA2DS2-VASc score and in-hospital mortality in the prognosis of intensive care unit (ICU) patients with COVID-19. Methods: Eighty-four COVID-19 patients who were hospitalized in the ICU were retrospectively analyzed in a tertiary health care center, and the CHA2DS2-VASc score was determined. All analyses were performed using SPSS statistical software (SPSS Inc., Chicago, IL, USA, 20.0). A p-value <0.05 was considered statistically significant. Results: The median age of patients was 60.0 years, and most were males (75.0%). Findings of the study showed that the CHA2DS2-VASc score was considerably higher among the hospitalized patients than discharged patients (3.08 ± 1.72 vs. 1.38 ± 1.16; p<0.001), and patients who required mechanical ventilation compared to those who did not require mechanical ventilation (3.03 ± 1.68 vs. 1.15 ± 0.97; P <0.001), respectively. Patients with CHA2DS2-VASc score of ≥3 had substantially higher age [67(45-87) vs. 58(19-75); P ˂0.001], computed tomography involvement score [67.5(20-90) vs. 35(15-90); P ˂0.001] and need for mechanical ventilation [29(90.6%) vs. 22(42.3%); P ˂0.001]. A significant difference was found in oxygen saturation on admission (P =0.001) between the two groups. In-hospital death was significantly higher among patients with a CHA2DS2-VASc score of ≥3 (P <0.001). The CHA2DS2-VASc score was positively correlated with white blood cells count (r=0.257, P =0.018) and negatively correlated with the number of days spent in the hospital (r=-0.184, P=0.130) due to higher in-hospital death in ICU patients with COVID-19. Conclusion: CHA2DS2-VASc score may be an effective tool to estimate in-hospital death in COVID-19 patients who were hospitalized in the ICU.
format	article
author	Mukesh Jha Utkarsh Mukesh Balani Vimlesh Pandey Prachi Balani Vipin Patel Abhishek Mehta
author_facet	Mukesh Jha Utkarsh Mukesh Balani Vimlesh Pandey Prachi Balani Vipin Patel Abhishek Mehta
author_sort	Mukesh Jha
title	Association between CHA2DS2-VASc score and in-hospital death in ICU patients with COVID-19
title_short	Association between CHA2DS2-VASc score and in-hospital death in ICU patients with COVID-19
title_full	Association between CHA2DS2-VASc score and in-hospital death in ICU patients with COVID-19
title_fullStr	Association between CHA2DS2-VASc score and in-hospital death in ICU patients with COVID-19
title_full_unstemmed	Association between CHA2DS2-VASc score and in-hospital death in ICU patients with COVID-19
title_sort	association between cha2ds2-vasc score and in-hospital death in icu patients with covid-19
publisher	Journal of Ideas in Health
publishDate	2021
url	https://doaj.org/article/a6b3af84d6bf4947b78579a35f631f82
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Association between CHA2DS2-VASc score and in-hospital death in ICU patients with COVID-19

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