The RTM resistance to potyviruses in Arabidopsis thaliana: natural variation of the RTM genes and evidence for the implication of additional genes.

<h4>Background</h4>The non conventional RTM (Restricted Tobacco etch virus Movement) resistance which restricts long distance movement of some plant viruses in Arabidopsis thaliana is still poorly understood. Though at least three RTM genes have been identified, their precise role(s) in...

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Autores principales:	Patrick Cosson, Valérie Schurdi-Levraud, Quang Hien Le, Ophélie Sicard, Mélodie Caballero, Fabrice Roux, Olivier Le Gall, Thierry Candresse, Frédéric Revers
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a6b4667155d740d1a4fdaef4c8d358a4
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spelling	oai:doaj.org-article:a6b4667155d740d1a4fdaef4c8d358a42021-11-18T07:15:08ZThe RTM resistance to potyviruses in Arabidopsis thaliana: natural variation of the RTM genes and evidence for the implication of additional genes.1932-620310.1371/journal.pone.0039169https://doaj.org/article/a6b4667155d740d1a4fdaef4c8d358a42012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22723957/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The non conventional RTM (Restricted Tobacco etch virus Movement) resistance which restricts long distance movement of some plant viruses in Arabidopsis thaliana is still poorly understood. Though at least three RTM genes have been identified, their precise role(s) in the process as well as whether other genes are involved needs to be elucidated.<h4>Methodology/principal findings</h4>In this study, the natural variation of the RTM genes was analysed at the amino acid level in relation with their functionality to restrict the long distance movement of Lettuce mosaic potyvirus (LMV). We identified non-functional RTM alleles in LMV-susceptible Arabidopsis accessions as well as some of the mutations leading to the non-functionality of the RTM proteins. Our data also indicate that more than 40% of the resistant accessions to LMV are controlled by the RTM genes. In addition, two new RTM loci were genetically identified.<h4>Conclusions/significance</h4>Our results show that the RTM resistance seems to be a complex biological process which would involves at least five different proteins. The next challenges will be to understand how the different RTM protein domains are involved in the resistance mechanism and to characterise the new RTM genes for a better understanding of the blocking of the long distance transport of plant viruses.Patrick CossonValérie Schurdi-LevraudQuang Hien LeOphélie SicardMélodie CaballeroFabrice RouxOlivier Le GallThierry CandresseFrédéric ReversPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e39169 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Patrick Cosson Valérie Schurdi-Levraud Quang Hien Le Ophélie Sicard Mélodie Caballero Fabrice Roux Olivier Le Gall Thierry Candresse Frédéric Revers The RTM resistance to potyviruses in Arabidopsis thaliana: natural variation of the RTM genes and evidence for the implication of additional genes.
description	<h4>Background</h4>The non conventional RTM (Restricted Tobacco etch virus Movement) resistance which restricts long distance movement of some plant viruses in Arabidopsis thaliana is still poorly understood. Though at least three RTM genes have been identified, their precise role(s) in the process as well as whether other genes are involved needs to be elucidated.<h4>Methodology/principal findings</h4>In this study, the natural variation of the RTM genes was analysed at the amino acid level in relation with their functionality to restrict the long distance movement of Lettuce mosaic potyvirus (LMV). We identified non-functional RTM alleles in LMV-susceptible Arabidopsis accessions as well as some of the mutations leading to the non-functionality of the RTM proteins. Our data also indicate that more than 40% of the resistant accessions to LMV are controlled by the RTM genes. In addition, two new RTM loci were genetically identified.<h4>Conclusions/significance</h4>Our results show that the RTM resistance seems to be a complex biological process which would involves at least five different proteins. The next challenges will be to understand how the different RTM protein domains are involved in the resistance mechanism and to characterise the new RTM genes for a better understanding of the blocking of the long distance transport of plant viruses.
format	article
author	Patrick Cosson Valérie Schurdi-Levraud Quang Hien Le Ophélie Sicard Mélodie Caballero Fabrice Roux Olivier Le Gall Thierry Candresse Frédéric Revers
author_facet	Patrick Cosson Valérie Schurdi-Levraud Quang Hien Le Ophélie Sicard Mélodie Caballero Fabrice Roux Olivier Le Gall Thierry Candresse Frédéric Revers
author_sort	Patrick Cosson
title	The RTM resistance to potyviruses in Arabidopsis thaliana: natural variation of the RTM genes and evidence for the implication of additional genes.
title_short	The RTM resistance to potyviruses in Arabidopsis thaliana: natural variation of the RTM genes and evidence for the implication of additional genes.
title_full	The RTM resistance to potyviruses in Arabidopsis thaliana: natural variation of the RTM genes and evidence for the implication of additional genes.
title_fullStr	The RTM resistance to potyviruses in Arabidopsis thaliana: natural variation of the RTM genes and evidence for the implication of additional genes.
title_full_unstemmed	The RTM resistance to potyviruses in Arabidopsis thaliana: natural variation of the RTM genes and evidence for the implication of additional genes.
title_sort	rtm resistance to potyviruses in arabidopsis thaliana: natural variation of the rtm genes and evidence for the implication of additional genes.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/a6b4667155d740d1a4fdaef4c8d358a4
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The RTM resistance to potyviruses in Arabidopsis thaliana: natural variation of the RTM genes and evidence for the implication of additional genes.

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