Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients

Abstract We aimed to investigate the endoscopic features and clinical course of CMV gastroenterocolitis in immunocompetent patients. We reviewed the medical records and endoscopic images of 86 immunocompetent patients with CMV gastroenterocolitis. Immunocompetent patients were defined as those witho...

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Autores principales:	Jiyoung Yoon, Junghwan Lee, Dae Sung Kim, Jin Wook Lee, Seung Wook Hong, Ha Won Hwang, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Seung-Jae Myung, Hwoon-Yong Jung, Suk-Kyun Yang, Jeong-Sik Byeon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a6b74fb2b0124aa8a5d8c01b57760571
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spelling	oai:doaj.org-article:a6b74fb2b0124aa8a5d8c01b577605712021-12-02T17:04:59ZEndoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients10.1038/s41598-021-85845-82045-2322https://doaj.org/article/a6b74fb2b0124aa8a5d8c01b577605712021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85845-8https://doaj.org/toc/2045-2322Abstract We aimed to investigate the endoscopic features and clinical course of CMV gastroenterocolitis in immunocompetent patients. We reviewed the medical records and endoscopic images of 86 immunocompetent patients with CMV gastroenterocolitis. Immunocompetent patients were defined as those without congenital or acquired immunodeficiency syndrome, use of anti-cancer chemotherapeutic and immunosuppressive agents, and inflammatory bowel diseases. The mean age was 65.5 ± 11.8 years and 53 (61.6%) were male. Sixty-eight (79.1%) patients had comorbidities. Upper gastrointestinal-dominant, small bowel-dominant, and colon-dominant types were observed in 19, 7, and 60 patients, respectively. Endoscopic features could be classified into discrete ulcerative type with/without exudate and diffuse erythematous type with/without exudate. Antiviral treatment with ganciclovir was initiated in 51 patients (59.3%), 40 of whom improved and 1 improved after changing ganciclovir to foscarnet. Thirty-three patients (38.4%) improved without antiviral treatment. Surgery was necessary in two patients because of colon perforation before antiviral treatment. Another two patients underwent surgery because of sigmoid stricture and cecal perforation during antiviral treatment. Endoscopic type was not associated with clinical outcomes, such as surgery and death. CMV gastroenterocolitis in immunocompetent patients mostly occur in older patients with comorbidities, and the endoscopic features vary with no association with clinical outcomes.Jiyoung YoonJunghwan LeeDae Sung KimJin Wook LeeSeung Wook HongHa Won HwangSung Wook HwangSang Hyoung ParkDong-Hoon YangByong Duk YeSeung-Jae MyungHwoon-Yong JungSuk-Kyun YangJeong-Sik ByeonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiyoung Yoon Junghwan Lee Dae Sung Kim Jin Wook Lee Seung Wook Hong Ha Won Hwang Sung Wook Hwang Sang Hyoung Park Dong-Hoon Yang Byong Duk Ye Seung-Jae Myung Hwoon-Yong Jung Suk-Kyun Yang Jeong-Sik Byeon Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients
description	Abstract We aimed to investigate the endoscopic features and clinical course of CMV gastroenterocolitis in immunocompetent patients. We reviewed the medical records and endoscopic images of 86 immunocompetent patients with CMV gastroenterocolitis. Immunocompetent patients were defined as those without congenital or acquired immunodeficiency syndrome, use of anti-cancer chemotherapeutic and immunosuppressive agents, and inflammatory bowel diseases. The mean age was 65.5 ± 11.8 years and 53 (61.6%) were male. Sixty-eight (79.1%) patients had comorbidities. Upper gastrointestinal-dominant, small bowel-dominant, and colon-dominant types were observed in 19, 7, and 60 patients, respectively. Endoscopic features could be classified into discrete ulcerative type with/without exudate and diffuse erythematous type with/without exudate. Antiviral treatment with ganciclovir was initiated in 51 patients (59.3%), 40 of whom improved and 1 improved after changing ganciclovir to foscarnet. Thirty-three patients (38.4%) improved without antiviral treatment. Surgery was necessary in two patients because of colon perforation before antiviral treatment. Another two patients underwent surgery because of sigmoid stricture and cecal perforation during antiviral treatment. Endoscopic type was not associated with clinical outcomes, such as surgery and death. CMV gastroenterocolitis in immunocompetent patients mostly occur in older patients with comorbidities, and the endoscopic features vary with no association with clinical outcomes.
format	article
author	Jiyoung Yoon Junghwan Lee Dae Sung Kim Jin Wook Lee Seung Wook Hong Ha Won Hwang Sung Wook Hwang Sang Hyoung Park Dong-Hoon Yang Byong Duk Ye Seung-Jae Myung Hwoon-Yong Jung Suk-Kyun Yang Jeong-Sik Byeon
author_facet	Jiyoung Yoon Junghwan Lee Dae Sung Kim Jin Wook Lee Seung Wook Hong Ha Won Hwang Sung Wook Hwang Sang Hyoung Park Dong-Hoon Yang Byong Duk Ye Seung-Jae Myung Hwoon-Yong Jung Suk-Kyun Yang Jeong-Sik Byeon
author_sort	Jiyoung Yoon
title	Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients
title_short	Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients
title_full	Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients
title_fullStr	Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients
title_full_unstemmed	Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients
title_sort	endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a6b74fb2b0124aa8a5d8c01b57760571
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Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients

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