Plk1 bound to Bub1 contributes to spindle assembly checkpoint activity during mitosis
Abstract For faithful chromosome segregation, the formation of stable kinetochore–microtubule attachment and its monitoring by the spindle assembly checkpoint (SAC) are coordinately regulated by mechanisms that are currently ill-defined. Here, we show that polo-like kinase 1 (Plk1), which is instrum...
Saved in:
Main Authors: | Masanori Ikeda, Kozo Tanaka |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2017
|
Subjects: | |
Online Access: | https://doaj.org/article/a6bc99e2b9d1486c985b8a8f2a6afb60 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation
by: Luying Jia, et al.
Published: (2016) -
Reverse engineering of the spindle assembly checkpoint.
by: Andreas Doncic, et al.
Published: (2009) -
Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling
by: Gang Zhang, et al.
Published: (2017) -
Deficient spindle assembly checkpoint in multiple myeloma.
by: Elena Díaz-Rodríguez, et al.
Published: (2011) -
Plk1 phosphorylation of CAP-H2 triggers chromosome condensation by condensin II at the early phase of mitosis
by: Yuya Kagami, et al.
Published: (2017)