Mature IgDlow/- B cells maintain tolerance by promoting regulatory T cell homeostasis

B cells produce antibodies to mediate various immune functions, but are also reported to negatively regulate immune responses. Here, the authors show that a subset of mature B cells expressing low levels of IgD, present in both mice and human, may pursue this regulatory function indirectly by induci...

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Autores principales:	Avijit Ray, Mohamed I. Khalil, Kirthi L. Pulakanti, Robert T. Burns, Cody J. Gurski, Sreemanti Basu, Demin Wang, Sridhar Rao, Bonnie N. Dittel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a6be2f1b8c89426188dea0ff476a0e02
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spelling	oai:doaj.org-article:a6be2f1b8c89426188dea0ff476a0e022021-12-02T14:39:18ZMature IgDlow/- B cells maintain tolerance by promoting regulatory T cell homeostasis10.1038/s41467-018-08122-92041-1723https://doaj.org/article/a6be2f1b8c89426188dea0ff476a0e022019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08122-9https://doaj.org/toc/2041-1723B cells produce antibodies to mediate various immune functions, but are also reported to negatively regulate immune responses. Here, the authors show that a subset of mature B cells expressing low levels of IgD, present in both mice and human, may pursue this regulatory function indirectly by inducing the proliferation of regulatory T cells via GITRL.Avijit RayMohamed I. KhalilKirthi L. PulakantiRobert T. BurnsCody J. GurskiSreemanti BasuDemin WangSridhar RaoBonnie N. DittelNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Avijit Ray Mohamed I. Khalil Kirthi L. Pulakanti Robert T. Burns Cody J. Gurski Sreemanti Basu Demin Wang Sridhar Rao Bonnie N. Dittel Mature IgDlow/- B cells maintain tolerance by promoting regulatory T cell homeostasis
description	B cells produce antibodies to mediate various immune functions, but are also reported to negatively regulate immune responses. Here, the authors show that a subset of mature B cells expressing low levels of IgD, present in both mice and human, may pursue this regulatory function indirectly by inducing the proliferation of regulatory T cells via GITRL.
format	article
author	Avijit Ray Mohamed I. Khalil Kirthi L. Pulakanti Robert T. Burns Cody J. Gurski Sreemanti Basu Demin Wang Sridhar Rao Bonnie N. Dittel
author_facet	Avijit Ray Mohamed I. Khalil Kirthi L. Pulakanti Robert T. Burns Cody J. Gurski Sreemanti Basu Demin Wang Sridhar Rao Bonnie N. Dittel
author_sort	Avijit Ray
title	Mature IgDlow/- B cells maintain tolerance by promoting regulatory T cell homeostasis
title_short	Mature IgDlow/- B cells maintain tolerance by promoting regulatory T cell homeostasis
title_full	Mature IgDlow/- B cells maintain tolerance by promoting regulatory T cell homeostasis
title_fullStr	Mature IgDlow/- B cells maintain tolerance by promoting regulatory T cell homeostasis
title_full_unstemmed	Mature IgDlow/- B cells maintain tolerance by promoting regulatory T cell homeostasis
title_sort	mature igdlow/- b cells maintain tolerance by promoting regulatory t cell homeostasis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a6be2f1b8c89426188dea0ff476a0e02
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Mature IgDlow/- B cells maintain tolerance by promoting regulatory T cell homeostasis

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