Correlation between serum factor VIII:C levels and deep vein thrombosis following gynecological surgery

Deep vein thrombosis (DVT) is common in patients following gynecological surgery. Coagulation factor VIII (FVIII) is an important part of the human coagulation system, and FVIII:C is a component of FVIII with anticoagulant activity. 800 patients who underwent gynecological surgery were enrolled. Gen...

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Autores principales:	Jiayi Liu, Cuiqin Sang, Zhenyu Zhang, Ying Jiang, Shuzhen Wang, Yao Li, Xiao Shi
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	deep vein thrombosis coagulation factor viii coagulation factor viii:c Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/a6bf037510fc467aa767412bc1aa80a7
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spelling	oai:doaj.org-article:a6bf037510fc467aa767412bc1aa80a72021-12-01T14:41:00ZCorrelation between serum factor VIII:C levels and deep vein thrombosis following gynecological surgery2165-59792165-598710.1080/21655979.2021.1981755https://doaj.org/article/a6bf037510fc467aa767412bc1aa80a72021-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1981755https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Deep vein thrombosis (DVT) is common in patients following gynecological surgery. Coagulation factor VIII (FVIII) is an important part of the human coagulation system, and FVIII:C is a component of FVIII with anticoagulant activity. 800 patients who underwent gynecological surgery were enrolled. General clinical data were harvested, and pre – and postoperative serum FVIII levels were determined. Lower-extremity ultrasound examination and/or postoperative pulmonary angiography were performed. Related data were analyzed statistically. DVT was the first manifestation of venous thromboembolism in all cases. There were a total of 46 cases, and the incidence of DVT was 5.8%. Progression to pulmonary embolism was confirmed in 16 cases, with an incidence of 2.0%. The independent risk factors for DVT after gynecological surgery were postoperative FVIII:C levels (odds ratio [OR] = 1.01), age (OR = 6.57), and operation time ≥3 hours (OR = 2.90) (P < 0.05). When the FVIII:C level was greater than the 75th centile (≥150 IU/dL), the risk of DVT was 2.99 times higher than that below the 25th centile (<100 IU/dL) (P < 0.05). When combined with the risk factor of operation time ≥3 hours, the risk increased to 3.17 times (P = 0.10). When combined with age ≥60 years, the risk was significantly increased, reaching 12.0 times (P < 0.05). Serum FVIII:C levels are an independent risk factor for DVT after gynecological surgery. Higher levels increase the risk of DVT after gynecological surgery, and they may have a dose-dependent relationship. A synergistic effect exists in combination with other risk factors, which further increases the risk.Jiayi LiuCuiqin SangZhenyu ZhangYing JiangShuzhen WangYao LiXiao ShiTaylor & Francis Grouparticledeep vein thrombosiscoagulation factor viiicoagulation factor viii:cBiotechnologyTP248.13-248.65ENBioengineered, Vol 12, Iss 2, Pp 9668-9677 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	deep vein thrombosis coagulation factor viii coagulation factor viii:c Biotechnology TP248.13-248.65
spellingShingle	deep vein thrombosis coagulation factor viii coagulation factor viii:c Biotechnology TP248.13-248.65 Jiayi Liu Cuiqin Sang Zhenyu Zhang Ying Jiang Shuzhen Wang Yao Li Xiao Shi Correlation between serum factor VIII:C levels and deep vein thrombosis following gynecological surgery
description	Deep vein thrombosis (DVT) is common in patients following gynecological surgery. Coagulation factor VIII (FVIII) is an important part of the human coagulation system, and FVIII:C is a component of FVIII with anticoagulant activity. 800 patients who underwent gynecological surgery were enrolled. General clinical data were harvested, and pre – and postoperative serum FVIII levels were determined. Lower-extremity ultrasound examination and/or postoperative pulmonary angiography were performed. Related data were analyzed statistically. DVT was the first manifestation of venous thromboembolism in all cases. There were a total of 46 cases, and the incidence of DVT was 5.8%. Progression to pulmonary embolism was confirmed in 16 cases, with an incidence of 2.0%. The independent risk factors for DVT after gynecological surgery were postoperative FVIII:C levels (odds ratio [OR] = 1.01), age (OR = 6.57), and operation time ≥3 hours (OR = 2.90) (P < 0.05). When the FVIII:C level was greater than the 75th centile (≥150 IU/dL), the risk of DVT was 2.99 times higher than that below the 25th centile (<100 IU/dL) (P < 0.05). When combined with the risk factor of operation time ≥3 hours, the risk increased to 3.17 times (P = 0.10). When combined with age ≥60 years, the risk was significantly increased, reaching 12.0 times (P < 0.05). Serum FVIII:C levels are an independent risk factor for DVT after gynecological surgery. Higher levels increase the risk of DVT after gynecological surgery, and they may have a dose-dependent relationship. A synergistic effect exists in combination with other risk factors, which further increases the risk.
format	article
author	Jiayi Liu Cuiqin Sang Zhenyu Zhang Ying Jiang Shuzhen Wang Yao Li Xiao Shi
author_facet	Jiayi Liu Cuiqin Sang Zhenyu Zhang Ying Jiang Shuzhen Wang Yao Li Xiao Shi
author_sort	Jiayi Liu
title	Correlation between serum factor VIII:C levels and deep vein thrombosis following gynecological surgery
title_short	Correlation between serum factor VIII:C levels and deep vein thrombosis following gynecological surgery
title_full	Correlation between serum factor VIII:C levels and deep vein thrombosis following gynecological surgery
title_fullStr	Correlation between serum factor VIII:C levels and deep vein thrombosis following gynecological surgery
title_full_unstemmed	Correlation between serum factor VIII:C levels and deep vein thrombosis following gynecological surgery
title_sort	correlation between serum factor viii:c levels and deep vein thrombosis following gynecological surgery
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/a6bf037510fc467aa767412bc1aa80a7
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_version_	1718405011803734016

Correlation between serum factor VIII:C levels and deep vein thrombosis following gynecological surgery

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