Telomere length is associated with growth in children in rural Bangladesh
Background: Previously, we demonstrated that a water, sanitation, handwashing, and nutritional intervention improved linear growth and was unexpectedly associated with shortened childhood telomere length (TL) (Lin et al., 2017). Here, we assessed the association between TL and growth. Methods: We me...
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eLife Sciences Publications Ltd
2021
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oai:doaj.org-article:a6bff1822cac4c6085fb92e12e879a292021-11-24T08:23:27ZTelomere length is associated with growth in children in rural Bangladesh10.7554/eLife.603892050-084Xe60389https://doaj.org/article/a6bff1822cac4c6085fb92e12e879a292021-09-01T00:00:00Zhttps://elifesciences.org/articles/60389https://doaj.org/toc/2050-084XBackground: Previously, we demonstrated that a water, sanitation, handwashing, and nutritional intervention improved linear growth and was unexpectedly associated with shortened childhood telomere length (TL) (Lin et al., 2017). Here, we assessed the association between TL and growth. Methods: We measured relative TL in whole blood from 713 children. We reported differences between the 10th percentile and 90th percentile of TL or change in TL distribution using generalized additive models, adjusted for potential confounders. Results: In cross-sectional analyses, long TL was associated with a higher length-for-age Z score at age 1 year (0.23 SD adjusted difference in length-for-age Z score [95% CI 0.05, 0.42; FDR-corrected p-value = 0.01]). TL was not associated with other outcomes. Conclusions: Consistent with the metabolic telomere attrition hypothesis, our previous trial findings support an adaptive role for telomere attrition, whereby active TL regulation is employed as a strategy to address ‘emergency states’ with increased energy requirements such as rapid growth during the first year of life. Although short periods of active telomere attrition may be essential to promote growth, this study suggests that a longer overall initial TL setting in the first 2 years of life could signal increased resilience against future telomere erosion events and healthy growth trajectories. Funding: Funded by the Bill and Melinda Gates Foundation. Clinical trial number: NCT01590095Audrie LinAndrew N MertensBenjamin F ArnoldSophia TanJue LinChristine P StewartAlan E HubbardShahjahan AliJade Benjamin-ChungAbul K ShoabMd Ziaur RahmanSyeda L FamidaMd Saheen HossenPalash MutsuddiSalma AktherMahbubur RahmanLeanne UnicombRuchira Tabassum NavedMd Mahfuz Al MamunKausar ParvinFirdaus S DhabharPatricia KarigerLia CH FernaldStephen P LubyJohn M Colford JreLife Sciences Publications Ltdarticletelomere lengthgrowthchilddevelopmental origins of healthlow-incomepediatric populationMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021) |
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| collection |
DOAJ |
| language |
EN |
| topic |
telomere length growth child developmental origins of health low-income pediatric population Medicine R Science Q Biology (General) QH301-705.5 |
| spellingShingle |
telomere length growth child developmental origins of health low-income pediatric population Medicine R Science Q Biology (General) QH301-705.5 Audrie Lin Andrew N Mertens Benjamin F Arnold Sophia Tan Jue Lin Christine P Stewart Alan E Hubbard Shahjahan Ali Jade Benjamin-Chung Abul K Shoab Md Ziaur Rahman Syeda L Famida Md Saheen Hossen Palash Mutsuddi Salma Akther Mahbubur Rahman Leanne Unicomb Ruchira Tabassum Naved Md Mahfuz Al Mamun Kausar Parvin Firdaus S Dhabhar Patricia Kariger Lia CH Fernald Stephen P Luby John M Colford Jr Telomere length is associated with growth in children in rural Bangladesh |
| description |
Background: Previously, we demonstrated that a water, sanitation, handwashing, and nutritional intervention improved linear growth and was unexpectedly associated with shortened childhood telomere length (TL) (Lin et al., 2017). Here, we assessed the association between TL and growth.
Methods: We measured relative TL in whole blood from 713 children. We reported differences between the 10th percentile and 90th percentile of TL or change in TL distribution using generalized additive models, adjusted for potential confounders.
Results: In cross-sectional analyses, long TL was associated with a higher length-for-age Z score at age 1 year (0.23 SD adjusted difference in length-for-age Z score [95% CI 0.05, 0.42; FDR-corrected p-value = 0.01]). TL was not associated with other outcomes.
Conclusions: Consistent with the metabolic telomere attrition hypothesis, our previous trial findings support an adaptive role for telomere attrition, whereby active TL regulation is employed as a strategy to address ‘emergency states’ with increased energy requirements such as rapid growth during the first year of life. Although short periods of active telomere attrition may be essential to promote growth, this study suggests that a longer overall initial TL setting in the first 2 years of life could signal increased resilience against future telomere erosion events and healthy growth trajectories.
Funding: Funded by the Bill and Melinda Gates Foundation.
Clinical trial number: NCT01590095 |
| format |
article |
| author |
Audrie Lin Andrew N Mertens Benjamin F Arnold Sophia Tan Jue Lin Christine P Stewart Alan E Hubbard Shahjahan Ali Jade Benjamin-Chung Abul K Shoab Md Ziaur Rahman Syeda L Famida Md Saheen Hossen Palash Mutsuddi Salma Akther Mahbubur Rahman Leanne Unicomb Ruchira Tabassum Naved Md Mahfuz Al Mamun Kausar Parvin Firdaus S Dhabhar Patricia Kariger Lia CH Fernald Stephen P Luby John M Colford Jr |
| author_facet |
Audrie Lin Andrew N Mertens Benjamin F Arnold Sophia Tan Jue Lin Christine P Stewart Alan E Hubbard Shahjahan Ali Jade Benjamin-Chung Abul K Shoab Md Ziaur Rahman Syeda L Famida Md Saheen Hossen Palash Mutsuddi Salma Akther Mahbubur Rahman Leanne Unicomb Ruchira Tabassum Naved Md Mahfuz Al Mamun Kausar Parvin Firdaus S Dhabhar Patricia Kariger Lia CH Fernald Stephen P Luby John M Colford Jr |
| author_sort |
Audrie Lin |
| title |
Telomere length is associated with growth in children in rural Bangladesh |
| title_short |
Telomere length is associated with growth in children in rural Bangladesh |
| title_full |
Telomere length is associated with growth in children in rural Bangladesh |
| title_fullStr |
Telomere length is associated with growth in children in rural Bangladesh |
| title_full_unstemmed |
Telomere length is associated with growth in children in rural Bangladesh |
| title_sort |
telomere length is associated with growth in children in rural bangladesh |
| publisher |
eLife Sciences Publications Ltd |
| publishDate |
2021 |
| url |
https://doaj.org/article/a6bff1822cac4c6085fb92e12e879a29 |
| work_keys_str_mv |
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