The Making and Breaking of Serine-ADP-Ribosylation in the DNA Damage Response
ADP-ribosylation is a widespread posttranslational modification that is of particular therapeutic relevance due to its involvement in DNA repair. In response to DNA damage, PARP1 and 2 are the main enzymes that catalyze ADP-ribosylation at damage sites. Recently, serine was identified as the primary...
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Autores principales: | Kira Schützenhofer, Johannes Gregor Matthias Rack, Ivan Ahel |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Frontiers Media S.A.
2021
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Acceso en línea: | https://doaj.org/article/a6c0b2c3e77d4bb3a4984da97dafc795 |
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