GABAB receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice
Abstract Previous studies suggest that signaling by the gamma-aminobutyric acid (GABA) type B receptor (GABABR) is involved in the regulation of binge eating, a disorder which might contribute to the development of obesity. Here, we show that intermittent access to a high fat diet (HFD) induced bing...
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Nature Portfolio
2021
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oai:doaj.org-article:a6c163f2cf0942a3b0a4e66cf7b17b422021-12-02T19:17:04ZGABAB receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice10.1038/s41598-021-98590-92045-2322https://doaj.org/article/a6c163f2cf0942a3b0a4e66cf7b17b422021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98590-9https://doaj.org/toc/2045-2322Abstract Previous studies suggest that signaling by the gamma-aminobutyric acid (GABA) type B receptor (GABABR) is involved in the regulation of binge eating, a disorder which might contribute to the development of obesity. Here, we show that intermittent access to a high fat diet (HFD) induced binge-like eating behavior with activation of dopamine receptor d1 (drd1)-expressing neurons in the caudate putamen (CPu) and nucleus accumbens (NAc) in wild-type (WT) mice. The activation of drd1-expressing neurons during binge-like eating was substantially increased in the CPu, but not in the NAc, in corticostriatal neuron-specific GABABR-deficient knockout (KO) mice compared to WT mice. Treatment with the GABABR agonist, baclofen, suppressed binge-like eating behavior in WT mice, but not in KO mice, as reported previously. Baclofen also suppressed the activation of drd1-expressing neurons in the CPu, but not in the NAc, during binge-like eating in WT mice. Thus, our data suggest that GABABR signaling in CPu neurons expressing drd1 suppresses binge-like consumption during a HFD in mice.Runan SunTaku TsunekawaTomonori HiroseHiroshi YaginumaKeigo TakiAkira MizoguchiTakashi MiyataTomoko KobayashiMariko SugiyamaTakeshi OnoueHiroshi TakagiDaisuke HagiwaraYoshihiro ItoShintaro IwamaHidetaka SugaRyoichi BannoBernhard BettlerHiroshi ArimaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
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Medicine R Science Q Runan Sun Taku Tsunekawa Tomonori Hirose Hiroshi Yaginuma Keigo Taki Akira Mizoguchi Takashi Miyata Tomoko Kobayashi Mariko Sugiyama Takeshi Onoue Hiroshi Takagi Daisuke Hagiwara Yoshihiro Ito Shintaro Iwama Hidetaka Suga Ryoichi Banno Bernhard Bettler Hiroshi Arima GABAB receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice |
| description |
Abstract Previous studies suggest that signaling by the gamma-aminobutyric acid (GABA) type B receptor (GABABR) is involved in the regulation of binge eating, a disorder which might contribute to the development of obesity. Here, we show that intermittent access to a high fat diet (HFD) induced binge-like eating behavior with activation of dopamine receptor d1 (drd1)-expressing neurons in the caudate putamen (CPu) and nucleus accumbens (NAc) in wild-type (WT) mice. The activation of drd1-expressing neurons during binge-like eating was substantially increased in the CPu, but not in the NAc, in corticostriatal neuron-specific GABABR-deficient knockout (KO) mice compared to WT mice. Treatment with the GABABR agonist, baclofen, suppressed binge-like eating behavior in WT mice, but not in KO mice, as reported previously. Baclofen also suppressed the activation of drd1-expressing neurons in the CPu, but not in the NAc, during binge-like eating in WT mice. Thus, our data suggest that GABABR signaling in CPu neurons expressing drd1 suppresses binge-like consumption during a HFD in mice. |
| format |
article |
| author |
Runan Sun Taku Tsunekawa Tomonori Hirose Hiroshi Yaginuma Keigo Taki Akira Mizoguchi Takashi Miyata Tomoko Kobayashi Mariko Sugiyama Takeshi Onoue Hiroshi Takagi Daisuke Hagiwara Yoshihiro Ito Shintaro Iwama Hidetaka Suga Ryoichi Banno Bernhard Bettler Hiroshi Arima |
| author_facet |
Runan Sun Taku Tsunekawa Tomonori Hirose Hiroshi Yaginuma Keigo Taki Akira Mizoguchi Takashi Miyata Tomoko Kobayashi Mariko Sugiyama Takeshi Onoue Hiroshi Takagi Daisuke Hagiwara Yoshihiro Ito Shintaro Iwama Hidetaka Suga Ryoichi Banno Bernhard Bettler Hiroshi Arima |
| author_sort |
Runan Sun |
| title |
GABAB receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice |
| title_short |
GABAB receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice |
| title_full |
GABAB receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice |
| title_fullStr |
GABAB receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice |
| title_full_unstemmed |
GABAB receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice |
| title_sort |
gabab receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/a6c163f2cf0942a3b0a4e66cf7b17b42 |
| work_keys_str_mv |
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1718376930042970112 |