Aβ initiates brain hypometabolism, network dysfunction and behavioral abnormalities via NOX2-induced oxidative stress in mice

Anton Malkov, Irina Popova et al. demonstrate that beta-amyloid application induces oxidative stress and reduces glucose consumption in the mouse brain, leading to network hyperactivity and behavioral changes—pathologies similar to those observed early on in Alzheimer’s disease patients. Inhibition...

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Autores principales:	Anton Malkov, Irina Popova, Anton Ivanov, Sung-Soo Jang, Seo Yeon Yoon, Alexander Osypov, Yadong Huang, Yuri Zilberter, Misha Zilberter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a6c2412d4513481a8cfa406b0388ad5a
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spelling	oai:doaj.org-article:a6c2412d4513481a8cfa406b0388ad5a2021-12-02T18:03:04ZAβ initiates brain hypometabolism, network dysfunction and behavioral abnormalities via NOX2-induced oxidative stress in mice10.1038/s42003-021-02551-x2399-3642https://doaj.org/article/a6c2412d4513481a8cfa406b0388ad5a2021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02551-xhttps://doaj.org/toc/2399-3642Anton Malkov, Irina Popova et al. demonstrate that beta-amyloid application induces oxidative stress and reduces glucose consumption in the mouse brain, leading to network hyperactivity and behavioral changes—pathologies similar to those observed early on in Alzheimer’s disease patients. Inhibition of NADPH oxidase 2 (NOX2) rescued these phenotypes, suggesting that NOX2 may represent an important therapeutic target for Alzheimer’s disease.Anton MalkovIrina PopovaAnton IvanovSung-Soo JangSeo Yeon YoonAlexander OsypovYadong HuangYuri ZilberterMisha ZilberterNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Anton Malkov Irina Popova Anton Ivanov Sung-Soo Jang Seo Yeon Yoon Alexander Osypov Yadong Huang Yuri Zilberter Misha Zilberter Aβ initiates brain hypometabolism, network dysfunction and behavioral abnormalities via NOX2-induced oxidative stress in mice
description	Anton Malkov, Irina Popova et al. demonstrate that beta-amyloid application induces oxidative stress and reduces glucose consumption in the mouse brain, leading to network hyperactivity and behavioral changes—pathologies similar to those observed early on in Alzheimer’s disease patients. Inhibition of NADPH oxidase 2 (NOX2) rescued these phenotypes, suggesting that NOX2 may represent an important therapeutic target for Alzheimer’s disease.
format	article
author	Anton Malkov Irina Popova Anton Ivanov Sung-Soo Jang Seo Yeon Yoon Alexander Osypov Yadong Huang Yuri Zilberter Misha Zilberter
author_facet	Anton Malkov Irina Popova Anton Ivanov Sung-Soo Jang Seo Yeon Yoon Alexander Osypov Yadong Huang Yuri Zilberter Misha Zilberter
author_sort	Anton Malkov
title	Aβ initiates brain hypometabolism, network dysfunction and behavioral abnormalities via NOX2-induced oxidative stress in mice
title_short	Aβ initiates brain hypometabolism, network dysfunction and behavioral abnormalities via NOX2-induced oxidative stress in mice
title_full	Aβ initiates brain hypometabolism, network dysfunction and behavioral abnormalities via NOX2-induced oxidative stress in mice
title_fullStr	Aβ initiates brain hypometabolism, network dysfunction and behavioral abnormalities via NOX2-induced oxidative stress in mice
title_full_unstemmed	Aβ initiates brain hypometabolism, network dysfunction and behavioral abnormalities via NOX2-induced oxidative stress in mice
title_sort	aβ initiates brain hypometabolism, network dysfunction and behavioral abnormalities via nox2-induced oxidative stress in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a6c2412d4513481a8cfa406b0388ad5a
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Aβ initiates brain hypometabolism, network dysfunction and behavioral abnormalities via NOX2-induced oxidative stress in mice

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