Age-related macular degeneration and premorbid allergic diseases: a population-based case–control study

Abstract Evidence indicates that age-related macular degeneration (AMD) is associated with the prior presence of allergic diseases; however, large-scale studies in the literature are limited. A case–control study was conducted to describe the relationship between premorbid allergic diseases and AMD...

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Autores principales:	Yi-Chen Shen, Ning-Yi Hsia, Wan-Hua Wu, Cheng-Li Lin, Te-Chun Shen, Wei-Chien Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a6c341f08a054788affc78514043bb98
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spelling	oai:doaj.org-article:a6c341f08a054788affc78514043bb982021-12-02T17:08:23ZAge-related macular degeneration and premorbid allergic diseases: a population-based case–control study10.1038/s41598-021-95937-02045-2322https://doaj.org/article/a6c341f08a054788affc78514043bb982021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95937-0https://doaj.org/toc/2045-2322Abstract Evidence indicates that age-related macular degeneration (AMD) is associated with the prior presence of allergic diseases; however, large-scale studies in the literature are limited. A case–control study was conducted to describe the relationship between premorbid allergic diseases and AMD using Taiwan’s National Health Insurance database. Eligibility criteria for inclusion of new adult AMD cases from 2000 to 2013 were set up. We defined the year of diagnosis as the index year. Age-, gender-, index year- matched controls who were drawn from the same database. The case control ratio was 1:4. For all participants, all premorbid conditions staring 1996 to index year were documented. Binary logistic regression was used to describe factors related to AMD occurrence. The AMD group consisted of 10,911 patients, and the comparison group consisted of 43,644 individuals. Patients with AMD showed significant associations with premorbid allergic diseases (aOR 1.54, 95% CI 1.47–1.61), specifically with allergic conjunctivitis (aOR 2.07, 95% CI 1.94–2.20), allergic rhinitis (aOR 1.32, 95% CI 1.25–1.39), asthma (aOR 0.99, 95% CI 0.93–1.06), and atopic dermatitis (aOR 1.04, 95% CI 0.94–1.17). Further analyses indicated that patients with more concurrent allergic diseases have higher associations with AMD than those with fewer concurrent diseases. Patients with more annual medical visits for their allergic diseases also showed higher associations with AMD than those with fewer visits. AMD is significantly associated with premorbid allergic diseases. The underlying mechanisms must be further investigated.Yi-Chen ShenNing-Yi HsiaWan-Hua WuCheng-Li LinTe-Chun ShenWei-Chien HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yi-Chen Shen Ning-Yi Hsia Wan-Hua Wu Cheng-Li Lin Te-Chun Shen Wei-Chien Huang Age-related macular degeneration and premorbid allergic diseases: a population-based case–control study
description	Abstract Evidence indicates that age-related macular degeneration (AMD) is associated with the prior presence of allergic diseases; however, large-scale studies in the literature are limited. A case–control study was conducted to describe the relationship between premorbid allergic diseases and AMD using Taiwan’s National Health Insurance database. Eligibility criteria for inclusion of new adult AMD cases from 2000 to 2013 were set up. We defined the year of diagnosis as the index year. Age-, gender-, index year- matched controls who were drawn from the same database. The case control ratio was 1:4. For all participants, all premorbid conditions staring 1996 to index year were documented. Binary logistic regression was used to describe factors related to AMD occurrence. The AMD group consisted of 10,911 patients, and the comparison group consisted of 43,644 individuals. Patients with AMD showed significant associations with premorbid allergic diseases (aOR 1.54, 95% CI 1.47–1.61), specifically with allergic conjunctivitis (aOR 2.07, 95% CI 1.94–2.20), allergic rhinitis (aOR 1.32, 95% CI 1.25–1.39), asthma (aOR 0.99, 95% CI 0.93–1.06), and atopic dermatitis (aOR 1.04, 95% CI 0.94–1.17). Further analyses indicated that patients with more concurrent allergic diseases have higher associations with AMD than those with fewer concurrent diseases. Patients with more annual medical visits for their allergic diseases also showed higher associations with AMD than those with fewer visits. AMD is significantly associated with premorbid allergic diseases. The underlying mechanisms must be further investigated.
format	article
author	Yi-Chen Shen Ning-Yi Hsia Wan-Hua Wu Cheng-Li Lin Te-Chun Shen Wei-Chien Huang
author_facet	Yi-Chen Shen Ning-Yi Hsia Wan-Hua Wu Cheng-Li Lin Te-Chun Shen Wei-Chien Huang
author_sort	Yi-Chen Shen
title	Age-related macular degeneration and premorbid allergic diseases: a population-based case–control study
title_short	Age-related macular degeneration and premorbid allergic diseases: a population-based case–control study
title_full	Age-related macular degeneration and premorbid allergic diseases: a population-based case–control study
title_fullStr	Age-related macular degeneration and premorbid allergic diseases: a population-based case–control study
title_full_unstemmed	Age-related macular degeneration and premorbid allergic diseases: a population-based case–control study
title_sort	age-related macular degeneration and premorbid allergic diseases: a population-based case–control study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a6c341f08a054788affc78514043bb98
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Age-related macular degeneration and premorbid allergic diseases: a population-based case–control study

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