A new data analysis approach for measuring longitudinal changes of metabolism in cognitively normal elderly adults

Sepideh Shokouhi,1 William R Riddle,1,&dagger; Hakmook Kang2 1Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; 2Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA &dagger;Dr William R Ridd...

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Autores principales:	Shokouhi S, Riddle WR, Kang H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	positron emission tomography FDG reference tissue normalization regional FDG time correlation metabolism Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/a6c38188ece04960b494982322621ea3
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spelling	oai:doaj.org-article:a6c38188ece04960b494982322621ea32021-12-02T01:49:48ZA new data analysis approach for measuring longitudinal changes of metabolism in cognitively normal elderly adults1178-1998https://doaj.org/article/a6c38188ece04960b494982322621ea32017-12-01T00:00:00Zhttps://www.dovepress.com/a-new-data-analysis-approach-for-measuring-longitudinal-changes-of-met-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Sepideh Shokouhi,1 William R Riddle,1,&dagger; Hakmook Kang2 1Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; 2Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA &dagger;Dr William R Riddle passed away on June 8, 2016 Introduction: Previously, we discussed several critical barriers in including [18F]fluorodeoxyglucose positron emission tomography ([18F]FDG-PET) imaging of preclinical Alzheimer’s disease (AD) subjects. These factors included the reference region selection and intensity normalization of PET images and the within- and across-subject variability of affected brain regions. In this study, we utilized a novel FDG-PET analysis, the regional FDG time correlation coefficient, rFTC, that can address and resolve these barriers and provide a more sensitive way of monitoring longitudinal changes in metabolism of cognitively normal elderly adults. The rFTC analysis captures the within-subject similarities between baseline and follow-up regional radiotracer distributions. Methods: The rFTC trajectories of 27 cognitively normal subjects were calculated to identify 1) trajectories of rFTC decline in individual cognitively normal subjects; 2) how these trajectories correlate with the subjects’ cognitive test scores, baseline cerebrospinal fluid (CSF) levels of amyloid beta (Aβ), and apolipoprotein E4 (APOE-E4) status; and 3) whether similar trajectories are observed in regional/composite standardized uptake value ratio (SUVR) values. Results: While some of the subjects maintained a stable rFTC trajectory, other subjects had declining and fluctuating rFTC values. We found that the rFTC decline was significantly higher in APOE-E4 carriers compared to noncarriers (p=0.04). We also found a marginally significant association between rFTC decline and cognitive decline measured by Alzheimer’s Disease Assessment Scale – cognitive subscale (ADAS_cog) decline (0.05). In comparison to the rFTC trajectories, the composite region of interest (ROI) SUVR trajectories did not change in any of the subjects. No individual/composite ROI SUVR changes contributed significantly to explaining changes in ADAS_cog, conversion to mild cognitive impairment (MCI), or any general changes in clinical symptoms. Conclusion: The rFTC decline may serve as a new biomarker of early metabolic changes before the MCI stage. Keywords: positron emission tomography, FDG, reference tissue normalization, regional FDG time correlation, metabolismShokouhi SRiddle WRKang HDove Medical Pressarticlepositron emission tomographyFDGreference tissue normalizationregional FDG time correlationmetabolismGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 2123-2130 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	positron emission tomography FDG reference tissue normalization regional FDG time correlation metabolism Geriatrics RC952-954.6
spellingShingle	positron emission tomography FDG reference tissue normalization regional FDG time correlation metabolism Geriatrics RC952-954.6 Shokouhi S Riddle WR Kang H A new data analysis approach for measuring longitudinal changes of metabolism in cognitively normal elderly adults
description	Sepideh Shokouhi,1 William R Riddle,1,&dagger; Hakmook Kang2 1Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; 2Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA &dagger;Dr William R Riddle passed away on June 8, 2016 Introduction: Previously, we discussed several critical barriers in including [18F]fluorodeoxyglucose positron emission tomography ([18F]FDG-PET) imaging of preclinical Alzheimer’s disease (AD) subjects. These factors included the reference region selection and intensity normalization of PET images and the within- and across-subject variability of affected brain regions. In this study, we utilized a novel FDG-PET analysis, the regional FDG time correlation coefficient, rFTC, that can address and resolve these barriers and provide a more sensitive way of monitoring longitudinal changes in metabolism of cognitively normal elderly adults. The rFTC analysis captures the within-subject similarities between baseline and follow-up regional radiotracer distributions. Methods: The rFTC trajectories of 27 cognitively normal subjects were calculated to identify 1) trajectories of rFTC decline in individual cognitively normal subjects; 2) how these trajectories correlate with the subjects’ cognitive test scores, baseline cerebrospinal fluid (CSF) levels of amyloid beta (Aβ), and apolipoprotein E4 (APOE-E4) status; and 3) whether similar trajectories are observed in regional/composite standardized uptake value ratio (SUVR) values. Results: While some of the subjects maintained a stable rFTC trajectory, other subjects had declining and fluctuating rFTC values. We found that the rFTC decline was significantly higher in APOE-E4 carriers compared to noncarriers (p=0.04). We also found a marginally significant association between rFTC decline and cognitive decline measured by Alzheimer’s Disease Assessment Scale – cognitive subscale (ADAS_cog) decline (0.05). In comparison to the rFTC trajectories, the composite region of interest (ROI) SUVR trajectories did not change in any of the subjects. No individual/composite ROI SUVR changes contributed significantly to explaining changes in ADAS_cog, conversion to mild cognitive impairment (MCI), or any general changes in clinical symptoms. Conclusion: The rFTC decline may serve as a new biomarker of early metabolic changes before the MCI stage. Keywords: positron emission tomography, FDG, reference tissue normalization, regional FDG time correlation, metabolism
format	article
author	Shokouhi S Riddle WR Kang H
author_facet	Shokouhi S Riddle WR Kang H
author_sort	Shokouhi S
title	A new data analysis approach for measuring longitudinal changes of metabolism in cognitively normal elderly adults
title_short	A new data analysis approach for measuring longitudinal changes of metabolism in cognitively normal elderly adults
title_full	A new data analysis approach for measuring longitudinal changes of metabolism in cognitively normal elderly adults
title_fullStr	A new data analysis approach for measuring longitudinal changes of metabolism in cognitively normal elderly adults
title_full_unstemmed	A new data analysis approach for measuring longitudinal changes of metabolism in cognitively normal elderly adults
title_sort	new data analysis approach for measuring longitudinal changes of metabolism in cognitively normal elderly adults
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/a6c38188ece04960b494982322621ea3
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A new data analysis approach for measuring longitudinal changes of metabolism in cognitively normal elderly adults

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