The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes

Pedro Manuel Baptista,1,2 Rita Vieira,1 André Ferreira,1,3 Ana Figueiredo,1 Isabel Sampaio,1 Rita Reis,1 Maria João Menéres1,2 1Ophthalmology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal; 2Instituto de CIências Biom&e...

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Autores principales:	Baptista PM, Vieira R, Ferreira A, Figueiredo A, Sampaio I, Reis R, Menéres MJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	glaucoma high myopia peripapillary retinal nerve fiber layer thickness optic disc dysgenesis papillary optical coherence tomography angiography circumpapillary microperimetry Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a6c635d6fd3d414fa5ce8ffc1f4fa0be
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spelling	oai:doaj.org-article:a6c635d6fd3d414fa5ce8ffc1f4fa0be2021-12-02T13:32:02ZThe Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes1177-5483https://doaj.org/article/a6c635d6fd3d414fa5ce8ffc1f4fa0be2021-03-01T00:00:00Zhttps://www.dovepress.com/the-role-of-multimodal-approach-in-the-assessment-of-glaucomatous-dama-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Pedro Manuel Baptista,1,2 Rita Vieira,1 André Ferreira,1,3 Ana Figueiredo,1 Isabel Sampaio,1 Rita Reis,1 Maria João Menéres1,2 1Ophthalmology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal; 2Instituto de CIências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal; 3Department of Biomedicine – Unit of Anatomy, Faculty of Medicine, Universidade do Porto, Porto, PortugalCorrespondence: Pedro Manuel BaptistaCentro Hospitalar Universitário do Porto, Largo Prof. Abel Salazar, Porto, 4099-001, PortugalTel +35 1917868372Email pedroyybaptista@gmail.comPurpose: To compare the optic disc structure and peripapillary retinal function between high myopes with and without glaucoma and to address the differential role of papillary optical coherence tomography angiography (OCT-A) and circumpapillary microperimetry (cpMP) on the diagnosis and prognosis of this patients.Patients and Methods: It is a cross-sectional study including 30 high myopic patients (60 eyes), divided into 15 with (GG) and 15 without glaucoma (NGG). Demographic and clinical data were collected from patient records. Papillary structure (peripapillary retinal nerve fiber layer thickness, ppRNFLTs) and vascularization (small vessel densities, SVD´s) were assessed with SD-OCT (RTVue XR Avanti, with AngioVue system, Optovue®). cpMP was carried out with the MP-3 microperimeter (Nidek®).Results: The GG were older, had lower best-corrected visual acuities and higher intraocular pressures and axial lengths (p< 0.001). The GG showed lower values in all ppRNFLTs (p< 0.05), lower values in all SVDs (p< 0.001), except the SVD-inside disc (p=0.638) and lower retinal sensitivities within all cpMPs (p< 0.001). The adjusted analysis computing the best two parameters per exam revealed that the anatomical model including the ppRNFLT-inferior and ppRNFLT-temporal and the vascular model including SVD-inferior and SVD-superior had the best discrimination power between groups, with cross-validated AUROCs of 0.9599 and 0.9921, respectively.Conclusion: Despite the apparent superiority of the papillary vascular study, a multimodal approach including the papillary anatomic and circumpapillary microperimetric assessments can be the new way on the diagnosis and prognosis of glaucoma in high myopia.Keywords: glaucoma, high myopia, peripapillary retinal nerve fiber layer thickness, optic disc dysgenesis, papillary optical coherence tomography angiography, circumpapillary microperimetryBaptista PMVieira RFerreira AFigueiredo ASampaio IReis RMenéres MJDove Medical Pressarticleglaucomahigh myopiaperipapillary retinal nerve fiber layer thicknessoptic disc dysgenesispapillary optical coherence tomography angiographycircumpapillary microperimetryOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 1061-1071 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	glaucoma high myopia peripapillary retinal nerve fiber layer thickness optic disc dysgenesis papillary optical coherence tomography angiography circumpapillary microperimetry Ophthalmology RE1-994
spellingShingle	glaucoma high myopia peripapillary retinal nerve fiber layer thickness optic disc dysgenesis papillary optical coherence tomography angiography circumpapillary microperimetry Ophthalmology RE1-994 Baptista PM Vieira R Ferreira A Figueiredo A Sampaio I Reis R Menéres MJ The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes
description	Pedro Manuel Baptista,1,2 Rita Vieira,1 André Ferreira,1,3 Ana Figueiredo,1 Isabel Sampaio,1 Rita Reis,1 Maria João Menéres1,2 1Ophthalmology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal; 2Instituto de CIências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal; 3Department of Biomedicine – Unit of Anatomy, Faculty of Medicine, Universidade do Porto, Porto, PortugalCorrespondence: Pedro Manuel BaptistaCentro Hospitalar Universitário do Porto, Largo Prof. Abel Salazar, Porto, 4099-001, PortugalTel +35 1917868372Email pedroyybaptista@gmail.comPurpose: To compare the optic disc structure and peripapillary retinal function between high myopes with and without glaucoma and to address the differential role of papillary optical coherence tomography angiography (OCT-A) and circumpapillary microperimetry (cpMP) on the diagnosis and prognosis of this patients.Patients and Methods: It is a cross-sectional study including 30 high myopic patients (60 eyes), divided into 15 with (GG) and 15 without glaucoma (NGG). Demographic and clinical data were collected from patient records. Papillary structure (peripapillary retinal nerve fiber layer thickness, ppRNFLTs) and vascularization (small vessel densities, SVD´s) were assessed with SD-OCT (RTVue XR Avanti, with AngioVue system, Optovue®). cpMP was carried out with the MP-3 microperimeter (Nidek®).Results: The GG were older, had lower best-corrected visual acuities and higher intraocular pressures and axial lengths (p< 0.001). The GG showed lower values in all ppRNFLTs (p< 0.05), lower values in all SVDs (p< 0.001), except the SVD-inside disc (p=0.638) and lower retinal sensitivities within all cpMPs (p< 0.001). The adjusted analysis computing the best two parameters per exam revealed that the anatomical model including the ppRNFLT-inferior and ppRNFLT-temporal and the vascular model including SVD-inferior and SVD-superior had the best discrimination power between groups, with cross-validated AUROCs of 0.9599 and 0.9921, respectively.Conclusion: Despite the apparent superiority of the papillary vascular study, a multimodal approach including the papillary anatomic and circumpapillary microperimetric assessments can be the new way on the diagnosis and prognosis of glaucoma in high myopia.Keywords: glaucoma, high myopia, peripapillary retinal nerve fiber layer thickness, optic disc dysgenesis, papillary optical coherence tomography angiography, circumpapillary microperimetry
format	article
author	Baptista PM Vieira R Ferreira A Figueiredo A Sampaio I Reis R Menéres MJ
author_facet	Baptista PM Vieira R Ferreira A Figueiredo A Sampaio I Reis R Menéres MJ
author_sort	Baptista PM
title	The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes
title_short	The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes
title_full	The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes
title_fullStr	The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes
title_full_unstemmed	The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes
title_sort	role of multimodal approach in the assessment of glaucomatous damage in high myopes
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/a6c635d6fd3d414fa5ce8ffc1f4fa0be
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The Role of Multimodal Approach in the Assessment of Glaucomatous Damage in High Myopes

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