Multifaceted catalytic hydrogenation of amides via diverse activation of a sterically confined bipyridine–ruthenium framework

Abstract Amides are ubiquitous and abundant in nature and our society, but are very stable and reluctant to salt-free, catalytic chemical transformations. Through the activation of a “sterically confined bipyridine–ruthenium (Ru) framework (molecularly well-designed site to confine adsorbed H2 in)”...

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Autores principales:	Takashi Miura, Masayuki Naruto, Katsuaki Toda, Taiki Shimomura, Susumu Saito
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a6c6cb4ce3f349cbb537fec468ef53b3
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spelling	oai:doaj.org-article:a6c6cb4ce3f349cbb537fec468ef53b32021-12-02T16:06:01ZMultifaceted catalytic hydrogenation of amides via diverse activation of a sterically confined bipyridine–ruthenium framework10.1038/s41598-017-01645-z2045-2322https://doaj.org/article/a6c6cb4ce3f349cbb537fec468ef53b32017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01645-zhttps://doaj.org/toc/2045-2322Abstract Amides are ubiquitous and abundant in nature and our society, but are very stable and reluctant to salt-free, catalytic chemical transformations. Through the activation of a “sterically confined bipyridine–ruthenium (Ru) framework (molecularly well-designed site to confine adsorbed H2 in)” of a precatalyst, catalytic hydrogenation of formamides through polyamide is achieved under a wide range of reaction conditions. Both C=O bond and C–N bond cleavage of a lactam became also possible using a single precatalyst. That is, catalyst diversity is induced by activation and stepwise multiple hydrogenation of a single precatalyst when the conditions are varied. The versatile catalysts have different structures and different resting states for multifaceted amide hydrogenation, but the common structure produced upon reaction with H2, which catalyzes hydrogenation, seems to be “H–Ru–N–H.”Takashi MiuraMasayuki NarutoKatsuaki TodaTaiki ShimomuraSusumu SaitoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takashi Miura Masayuki Naruto Katsuaki Toda Taiki Shimomura Susumu Saito Multifaceted catalytic hydrogenation of amides via diverse activation of a sterically confined bipyridine–ruthenium framework
description	Abstract Amides are ubiquitous and abundant in nature and our society, but are very stable and reluctant to salt-free, catalytic chemical transformations. Through the activation of a “sterically confined bipyridine–ruthenium (Ru) framework (molecularly well-designed site to confine adsorbed H2 in)” of a precatalyst, catalytic hydrogenation of formamides through polyamide is achieved under a wide range of reaction conditions. Both C=O bond and C–N bond cleavage of a lactam became also possible using a single precatalyst. That is, catalyst diversity is induced by activation and stepwise multiple hydrogenation of a single precatalyst when the conditions are varied. The versatile catalysts have different structures and different resting states for multifaceted amide hydrogenation, but the common structure produced upon reaction with H2, which catalyzes hydrogenation, seems to be “H–Ru–N–H.”
format	article
author	Takashi Miura Masayuki Naruto Katsuaki Toda Taiki Shimomura Susumu Saito
author_facet	Takashi Miura Masayuki Naruto Katsuaki Toda Taiki Shimomura Susumu Saito
author_sort	Takashi Miura
title	Multifaceted catalytic hydrogenation of amides via diverse activation of a sterically confined bipyridine–ruthenium framework
title_short	Multifaceted catalytic hydrogenation of amides via diverse activation of a sterically confined bipyridine–ruthenium framework
title_full	Multifaceted catalytic hydrogenation of amides via diverse activation of a sterically confined bipyridine–ruthenium framework
title_fullStr	Multifaceted catalytic hydrogenation of amides via diverse activation of a sterically confined bipyridine–ruthenium framework
title_full_unstemmed	Multifaceted catalytic hydrogenation of amides via diverse activation of a sterically confined bipyridine–ruthenium framework
title_sort	multifaceted catalytic hydrogenation of amides via diverse activation of a sterically confined bipyridine–ruthenium framework
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a6c6cb4ce3f349cbb537fec468ef53b3
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Multifaceted catalytic hydrogenation of amides via diverse activation of a sterically confined bipyridine–ruthenium framework

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