An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism

Hydroxyglutarate synthase (HglS) converts 2-oxoadipate to D-2- hydroxyglutarate during lysine catabolism in bacteria. Here the authors use structural and biochemical approaches to show that HglS acts via successive decarboxylation and intramolecular hydroxylation and that homologous enzymes catalyze...

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Autores principales:	Mitchell G. Thompson, Jacquelyn M. Blake-Hedges, Jose Henrique Pereira, John A. Hangasky, Michael S. Belcher, William M. Moore, Jesus F. Barajas, Pablo Cruz-Morales, Lorenzo J. Washington, Robert W. Haushalter, Christopher B. Eiben, Yuzhong Liu, Will Skyrud, Veronica T. Benites, Tyler P. Barnum, Edward E. K. Baidoo, Henrik V. Scheller, Michael A. Marletta, Patrick M. Shih, Paul D. Adams, Jay D. Keasling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a6c6f19696ff49aaac6e98cf1d7e8b64
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spelling	oai:doaj.org-article:a6c6f19696ff49aaac6e98cf1d7e8b642021-12-02T17:34:30ZAn iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism10.1038/s41467-020-16815-32041-1723https://doaj.org/article/a6c6f19696ff49aaac6e98cf1d7e8b642020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16815-3https://doaj.org/toc/2041-1723Hydroxyglutarate synthase (HglS) converts 2-oxoadipate to D-2- hydroxyglutarate during lysine catabolism in bacteria. Here the authors use structural and biochemical approaches to show that HglS acts via successive decarboxylation and intramolecular hydroxylation and that homologous enzymes catalyze the final step of lysine catabolism in plants.Mitchell G. ThompsonJacquelyn M. Blake-HedgesJose Henrique PereiraJohn A. HangaskyMichael S. BelcherWilliam M. MooreJesus F. BarajasPablo Cruz-MoralesLorenzo J. WashingtonRobert W. HaushalterChristopher B. EibenYuzhong LiuWill SkyrudVeronica T. BenitesTyler P. BarnumEdward E. K. BaidooHenrik V. SchellerMichael A. MarlettaPatrick M. ShihPaul D. AdamsJay D. KeaslingNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mitchell G. Thompson Jacquelyn M. Blake-Hedges Jose Henrique Pereira John A. Hangasky Michael S. Belcher William M. Moore Jesus F. Barajas Pablo Cruz-Morales Lorenzo J. Washington Robert W. Haushalter Christopher B. Eiben Yuzhong Liu Will Skyrud Veronica T. Benites Tyler P. Barnum Edward E. K. Baidoo Henrik V. Scheller Michael A. Marletta Patrick M. Shih Paul D. Adams Jay D. Keasling An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism
description	Hydroxyglutarate synthase (HglS) converts 2-oxoadipate to D-2- hydroxyglutarate during lysine catabolism in bacteria. Here the authors use structural and biochemical approaches to show that HglS acts via successive decarboxylation and intramolecular hydroxylation and that homologous enzymes catalyze the final step of lysine catabolism in plants.
format	article
author	Mitchell G. Thompson Jacquelyn M. Blake-Hedges Jose Henrique Pereira John A. Hangasky Michael S. Belcher William M. Moore Jesus F. Barajas Pablo Cruz-Morales Lorenzo J. Washington Robert W. Haushalter Christopher B. Eiben Yuzhong Liu Will Skyrud Veronica T. Benites Tyler P. Barnum Edward E. K. Baidoo Henrik V. Scheller Michael A. Marletta Patrick M. Shih Paul D. Adams Jay D. Keasling
author_facet	Mitchell G. Thompson Jacquelyn M. Blake-Hedges Jose Henrique Pereira John A. Hangasky Michael S. Belcher William M. Moore Jesus F. Barajas Pablo Cruz-Morales Lorenzo J. Washington Robert W. Haushalter Christopher B. Eiben Yuzhong Liu Will Skyrud Veronica T. Benites Tyler P. Barnum Edward E. K. Baidoo Henrik V. Scheller Michael A. Marletta Patrick M. Shih Paul D. Adams Jay D. Keasling
author_sort	Mitchell G. Thompson
title	An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism
title_short	An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism
title_full	An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism
title_fullStr	An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism
title_full_unstemmed	An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism
title_sort	iron (ii) dependent oxygenase performs the last missing step of plant lysine catabolism
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a6c6f19696ff49aaac6e98cf1d7e8b64
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An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism

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