Direct control of CAR T cells through small molecule-regulated antibodies

Many next-generation antibody therapeutics have enhanced potency but the risk of adverse events. Here the authors develop a conditionally activated, single-module CAR.

Guardado en:

Detalles Bibliográficos
Autores principales:	Spencer Park, Edward Pascua, Kevin C. Lindquist, Christopher Kimberlin, Xiaodi Deng, Yvonne S. L. Mak, Zea Melton, Theodore O. Johnson, Regina Lin, Bijan Boldajipour, Robert T. Abraham, Jaume Pons, Barbra Johnson Sasu, Thomas J. Van Blarcom, Javier Chaparro-Riggers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a6c74f8c5d424b06a2dbc5aa3382a4ec
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a6c74f8c5d424b06a2dbc5aa3382a4ec
record_format	dspace
spelling	oai:doaj.org-article:a6c74f8c5d424b06a2dbc5aa3382a4ec2021-12-02T10:48:28ZDirect control of CAR T cells through small molecule-regulated antibodies10.1038/s41467-020-20671-62041-1723https://doaj.org/article/a6c74f8c5d424b06a2dbc5aa3382a4ec2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20671-6https://doaj.org/toc/2041-1723Many next-generation antibody therapeutics have enhanced potency but the risk of adverse events. Here the authors develop a conditionally activated, single-module CAR.Spencer ParkEdward PascuaKevin C. LindquistChristopher KimberlinXiaodi DengYvonne S. L. MakZea MeltonTheodore O. JohnsonRegina LinBijan BoldajipourRobert T. AbrahamJaume PonsBarbra Johnson SasuThomas J. Van BlarcomJavier Chaparro-RiggersNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Spencer Park Edward Pascua Kevin C. Lindquist Christopher Kimberlin Xiaodi Deng Yvonne S. L. Mak Zea Melton Theodore O. Johnson Regina Lin Bijan Boldajipour Robert T. Abraham Jaume Pons Barbra Johnson Sasu Thomas J. Van Blarcom Javier Chaparro-Riggers Direct control of CAR T cells through small molecule-regulated antibodies
description	Many next-generation antibody therapeutics have enhanced potency but the risk of adverse events. Here the authors develop a conditionally activated, single-module CAR.
format	article
author	Spencer Park Edward Pascua Kevin C. Lindquist Christopher Kimberlin Xiaodi Deng Yvonne S. L. Mak Zea Melton Theodore O. Johnson Regina Lin Bijan Boldajipour Robert T. Abraham Jaume Pons Barbra Johnson Sasu Thomas J. Van Blarcom Javier Chaparro-Riggers
author_facet	Spencer Park Edward Pascua Kevin C. Lindquist Christopher Kimberlin Xiaodi Deng Yvonne S. L. Mak Zea Melton Theodore O. Johnson Regina Lin Bijan Boldajipour Robert T. Abraham Jaume Pons Barbra Johnson Sasu Thomas J. Van Blarcom Javier Chaparro-Riggers
author_sort	Spencer Park
title	Direct control of CAR T cells through small molecule-regulated antibodies
title_short	Direct control of CAR T cells through small molecule-regulated antibodies
title_full	Direct control of CAR T cells through small molecule-regulated antibodies
title_fullStr	Direct control of CAR T cells through small molecule-regulated antibodies
title_full_unstemmed	Direct control of CAR T cells through small molecule-regulated antibodies
title_sort	direct control of car t cells through small molecule-regulated antibodies
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a6c74f8c5d424b06a2dbc5aa3382a4ec
work_keys_str_mv	AT spencerpark directcontrolofcartcellsthroughsmallmoleculeregulatedantibodies AT edwardpascua directcontrolofcartcellsthroughsmallmoleculeregulatedantibodies AT kevinclindquist directcontrolofcartcellsthroughsmallmoleculeregulatedantibodies AT christopherkimberlin directcontrolofcartcellsthroughsmallmoleculeregulatedantibodies AT xiaodideng directcontrolofcartcellsthroughsmallmoleculeregulatedantibodies AT yvonneslmak directcontrolofcartcellsthroughsmallmoleculeregulatedantibodies AT zeamelton directcontrolofcartcellsthroughsmallmoleculeregulatedantibodies AT theodoreojohnson directcontrolofcartcellsthroughsmallmoleculeregulatedantibodies AT reginalin directcontrolofcartcellsthroughsmallmoleculeregulatedantibodies AT bijanboldajipour directcontrolofcartcellsthroughsmallmoleculeregulatedantibodies AT roberttabraham directcontrolofcartcellsthroughsmallmoleculeregulatedantibodies AT jaumepons directcontrolofcartcellsthroughsmallmoleculeregulatedantibodies AT barbrajohnsonsasu directcontrolofcartcellsthroughsmallmoleculeregulatedantibodies AT thomasjvanblarcom directcontrolofcartcellsthroughsmallmoleculeregulatedantibodies AT javierchaparroriggers directcontrolofcartcellsthroughsmallmoleculeregulatedantibodies
_version_	1718396667122679808

Direct control of CAR T cells through small molecule-regulated antibodies

Ejemplares similares