Direct control of CAR T cells through small molecule-regulated antibodies

Direct control of CAR T cells through small molecule-regulated antibodies

Many next-generation antibody therapeutics have enhanced potency but the risk of adverse events. Here the authors develop a conditionally activated, single-module CAR.

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Détails bibliographiques
Auteurs principaux: Spencer Park, Edward Pascua, Kevin C. Lindquist, Christopher Kimberlin, Xiaodi Deng, Yvonne S. L. Mak, Zea Melton, Theodore O. Johnson, Regina Lin, Bijan Boldajipour, Robert T. Abraham, Jaume Pons, Barbra Johnson Sasu, Thomas J. Van Blarcom, Javier Chaparro-Riggers
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Science
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Accès en ligne:https://doaj.org/article/a6c74f8c5d424b06a2dbc5aa3382a4ec
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Internet

https://doaj.org/article/a6c74f8c5d424b06a2dbc5aa3382a4ec

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