MLK4 regulates DNA damage response and promotes triple-negative breast cancer chemoresistance

MLK4 regulates DNA damage response and promotes triple-negative breast cancer chemoresistance

Abstract Chemoresistance constitutes a major challenge in the treatment of triple-negative breast cancer (TNBC). Mixed-Lineage Kinase 4 (MLK4) is frequently amplified or overexpressed in TNBC where it facilitates the aggressive growth and migratory potential of breast cancer cells. However, the func...

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Autores principales: Dawid Mehlich, Michał Łomiak, Aleksandra Sobiborowicz, Alicja Mazan, Dagmara Dymerska, Łukasz M. Szewczyk, Anna Mehlich, Agnieszka Borowiec, Monika K. Prełowska, Adam Gorczyński, Paweł Jabłoński, Ewa Iżycka-Świeszewska, Dominika Nowis, Anna A. Marusiak
Formato: article
Lenguaje:EN
Publicado: Nature Publishing Group 2021
Materias:
Cytology
QH573-671
Acceso en línea:https://doaj.org/article/a6cbcdae3c1744a89c3691e28b0246d5
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