Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers

Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers

Aromatase inhibitors are used to treat oestrogen-receptor-positive breast cancer. Here, the authors use genomic approaches to analyse tumours before and after neo-adjuvant treatment and find that treatment alters the clonal landscape of the tumours.

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Autores principales: Christopher A. Miller, Yevgeniy Gindin, Charles Lu, Obi L Griffith, Malachi Griffith, Dong Shen, Jeremy Hoog, Tiandao Li, David E. Larson, Mark Watson, Sherri R Davies, Kelly Hunt, Vera J. Suman, Jacqueline Snider, Thomas Walsh, Graham A. Colditz, Katherine DeSchryver, Richard K. Wilson, Elaine R. Mardis, Matthew J. Ellis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Q
Acceso en línea:https://doaj.org/article/a6ce0b4a6c5a4496be23087aef9be2f5
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spelling oai:doaj.org-article:a6ce0b4a6c5a4496be23087aef9be2f52021-12-02T15:35:20ZAromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers10.1038/ncomms124982041-1723https://doaj.org/article/a6ce0b4a6c5a4496be23087aef9be2f52016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12498https://doaj.org/toc/2041-1723Aromatase inhibitors are used to treat oestrogen-receptor-positive breast cancer. Here, the authors use genomic approaches to analyse tumours before and after neo-adjuvant treatment and find that treatment alters the clonal landscape of the tumours.Christopher A. MillerYevgeniy GindinCharles LuObi L GriffithMalachi GriffithDong ShenJeremy HoogTiandao LiDavid E. LarsonMark WatsonSherri R DaviesKelly HuntVera J. SumanJacqueline SniderThomas WalshGraham A. ColditzKatherine DeSchryverRichard K. WilsonElaine R. MardisMatthew J. EllisNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Christopher A. Miller
Yevgeniy Gindin
Charles Lu
Obi L Griffith
Malachi Griffith
Dong Shen
Jeremy Hoog
Tiandao Li
David E. Larson
Mark Watson
Sherri R Davies
Kelly Hunt
Vera J. Suman
Jacqueline Snider
Thomas Walsh
Graham A. Colditz
Katherine DeSchryver
Richard K. Wilson
Elaine R. Mardis
Matthew J. Ellis
Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers
description Aromatase inhibitors are used to treat oestrogen-receptor-positive breast cancer. Here, the authors use genomic approaches to analyse tumours before and after neo-adjuvant treatment and find that treatment alters the clonal landscape of the tumours.
format article
author Christopher A. Miller
Yevgeniy Gindin
Charles Lu
Obi L Griffith
Malachi Griffith
Dong Shen
Jeremy Hoog
Tiandao Li
David E. Larson
Mark Watson
Sherri R Davies
Kelly Hunt
Vera J. Suman
Jacqueline Snider
Thomas Walsh
Graham A. Colditz
Katherine DeSchryver
Richard K. Wilson
Elaine R. Mardis
Matthew J. Ellis
author_facet Christopher A. Miller
Yevgeniy Gindin
Charles Lu
Obi L Griffith
Malachi Griffith
Dong Shen
Jeremy Hoog
Tiandao Li
David E. Larson
Mark Watson
Sherri R Davies
Kelly Hunt
Vera J. Suman
Jacqueline Snider
Thomas Walsh
Graham A. Colditz
Katherine DeSchryver
Richard K. Wilson
Elaine R. Mardis
Matthew J. Ellis
author_sort Christopher A. Miller
title Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers
title_short Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers
title_full Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers
title_fullStr Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers
title_full_unstemmed Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers
title_sort aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/a6ce0b4a6c5a4496be23087aef9be2f5
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