The combination of malnutrition-inflammation and functional status limitations is associated with mortality in hemodialysis patients

Abstract The identification of malnutrition-inflammation-complex (MIC) and functional status (FS) is key to improving patient experience on hemodialysis (HD). We investigate the association of MIC and FS combinations with mortality in HD patients. We analyzed data from 5630 HD patients from 9 countr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eiichiro Kanda, Marcelo Barreto Lopes, Kazuhiko Tsuruya, Hideki Hirakata, Kunitoshi Iseki, Angelo Karaboyas, Brian Bieber, Stefan H. Jacobson, Indranil Dasgupta, Bruce M. Robinson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a6ce3f5ccf3c4c69bd95cf49e823d086
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a6ce3f5ccf3c4c69bd95cf49e823d086
record_format	dspace
spelling	oai:doaj.org-article:a6ce3f5ccf3c4c69bd95cf49e823d0862021-12-02T15:22:57ZThe combination of malnutrition-inflammation and functional status limitations is associated with mortality in hemodialysis patients10.1038/s41598-020-80716-02045-2322https://doaj.org/article/a6ce3f5ccf3c4c69bd95cf49e823d0862021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80716-0https://doaj.org/toc/2045-2322Abstract The identification of malnutrition-inflammation-complex (MIC) and functional status (FS) is key to improving patient experience on hemodialysis (HD). We investigate the association of MIC and FS combinations with mortality in HD patients. We analyzed data from 5630 HD patients from 9 countries in DOPPS phases 4–5 (2009–2015) with a median follow-up of 23 [IQR 11, 31] months. MIC was defined as serum albumin < 3.8 g/dL and serum C-reactive protein > 3 mg/L in Japan and > 10 mg/L elsewhere. FS score was defined as the sum of scores from the Katz Index of Independence in Activities of Daily Living and the Lawton-Brody Instrumental Activities of Daily Living Scale. We investigated the association between combinations of MIC (+/−) and FS (low [< 11]/high [≥ 11]) with death. Compared to the reference group (MIC−/high FS), the adjusted hazard ratios [HR (95% CI)] for all-cause mortality were 1.82 (1.49, 2.21) for MIC−/low FS, 1.57 (1.30, 1.89) for MIC+/high FS, and 3.44 (2.80, 4.23) for MIC+/low FS groups. Similar associations were observed with CVD-related and infection-related mortality. The combination of MIC and low FS is a strong predictor of mortality in HD patients. Identification of MIC and poor FS may direct interventions to lessen adverse clinical outcomes in the HD setting.Eiichiro KandaMarcelo Barreto LopesKazuhiko TsuruyaHideki HirakataKunitoshi IsekiAngelo KaraboyasBrian BieberStefan H. JacobsonIndranil DasguptaBruce M. RobinsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eiichiro Kanda Marcelo Barreto Lopes Kazuhiko Tsuruya Hideki Hirakata Kunitoshi Iseki Angelo Karaboyas Brian Bieber Stefan H. Jacobson Indranil Dasgupta Bruce M. Robinson The combination of malnutrition-inflammation and functional status limitations is associated with mortality in hemodialysis patients
description	Abstract The identification of malnutrition-inflammation-complex (MIC) and functional status (FS) is key to improving patient experience on hemodialysis (HD). We investigate the association of MIC and FS combinations with mortality in HD patients. We analyzed data from 5630 HD patients from 9 countries in DOPPS phases 4–5 (2009–2015) with a median follow-up of 23 [IQR 11, 31] months. MIC was defined as serum albumin < 3.8 g/dL and serum C-reactive protein > 3 mg/L in Japan and > 10 mg/L elsewhere. FS score was defined as the sum of scores from the Katz Index of Independence in Activities of Daily Living and the Lawton-Brody Instrumental Activities of Daily Living Scale. We investigated the association between combinations of MIC (+/−) and FS (low [< 11]/high [≥ 11]) with death. Compared to the reference group (MIC−/high FS), the adjusted hazard ratios [HR (95% CI)] for all-cause mortality were 1.82 (1.49, 2.21) for MIC−/low FS, 1.57 (1.30, 1.89) for MIC+/high FS, and 3.44 (2.80, 4.23) for MIC+/low FS groups. Similar associations were observed with CVD-related and infection-related mortality. The combination of MIC and low FS is a strong predictor of mortality in HD patients. Identification of MIC and poor FS may direct interventions to lessen adverse clinical outcomes in the HD setting.
format	article
author	Eiichiro Kanda Marcelo Barreto Lopes Kazuhiko Tsuruya Hideki Hirakata Kunitoshi Iseki Angelo Karaboyas Brian Bieber Stefan H. Jacobson Indranil Dasgupta Bruce M. Robinson
author_facet	Eiichiro Kanda Marcelo Barreto Lopes Kazuhiko Tsuruya Hideki Hirakata Kunitoshi Iseki Angelo Karaboyas Brian Bieber Stefan H. Jacobson Indranil Dasgupta Bruce M. Robinson
author_sort	Eiichiro Kanda
title	The combination of malnutrition-inflammation and functional status limitations is associated with mortality in hemodialysis patients
title_short	The combination of malnutrition-inflammation and functional status limitations is associated with mortality in hemodialysis patients
title_full	The combination of malnutrition-inflammation and functional status limitations is associated with mortality in hemodialysis patients
title_fullStr	The combination of malnutrition-inflammation and functional status limitations is associated with mortality in hemodialysis patients
title_full_unstemmed	The combination of malnutrition-inflammation and functional status limitations is associated with mortality in hemodialysis patients
title_sort	combination of malnutrition-inflammation and functional status limitations is associated with mortality in hemodialysis patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a6ce3f5ccf3c4c69bd95cf49e823d086
work_keys_str_mv	AT eiichirokanda thecombinationofmalnutritioninflammationandfunctionalstatuslimitationsisassociatedwithmortalityinhemodialysispatients AT marcelobarretolopes thecombinationofmalnutritioninflammationandfunctionalstatuslimitationsisassociatedwithmortalityinhemodialysispatients AT kazuhikotsuruya thecombinationofmalnutritioninflammationandfunctionalstatuslimitationsisassociatedwithmortalityinhemodialysispatients AT hidekihirakata thecombinationofmalnutritioninflammationandfunctionalstatuslimitationsisassociatedwithmortalityinhemodialysispatients AT kunitoshiiseki thecombinationofmalnutritioninflammationandfunctionalstatuslimitationsisassociatedwithmortalityinhemodialysispatients AT angelokaraboyas thecombinationofmalnutritioninflammationandfunctionalstatuslimitationsisassociatedwithmortalityinhemodialysispatients AT brianbieber thecombinationofmalnutritioninflammationandfunctionalstatuslimitationsisassociatedwithmortalityinhemodialysispatients AT stefanhjacobson thecombinationofmalnutritioninflammationandfunctionalstatuslimitationsisassociatedwithmortalityinhemodialysispatients AT indranildasgupta thecombinationofmalnutritioninflammationandfunctionalstatuslimitationsisassociatedwithmortalityinhemodialysispatients AT brucemrobinson thecombinationofmalnutritioninflammationandfunctionalstatuslimitationsisassociatedwithmortalityinhemodialysispatients AT eiichirokanda combinationofmalnutritioninflammationandfunctionalstatuslimitationsisassociatedwithmortalityinhemodialysispatients AT marcelobarretolopes combinationofmalnutritioninflammationandfunctionalstatuslimitationsisassociatedwithmortalityinhemodialysispatients AT kazuhikotsuruya combinationofmalnutritioninflammationandfunctionalstatuslimitationsisassociatedwithmortalityinhemodialysispatients AT hidekihirakata combinationofmalnutritioninflammationandfunctionalstatuslimitationsisassociatedwithmortalityinhemodialysispatients AT kunitoshiiseki combinationofmalnutritioninflammationandfunctionalstatuslimitationsisassociatedwithmortalityinhemodialysispatients AT angelokaraboyas combinationofmalnutritioninflammationandfunctionalstatuslimitationsisassociatedwithmortalityinhemodialysispatients AT brianbieber combinationofmalnutritioninflammationandfunctionalstatuslimitationsisassociatedwithmortalityinhemodialysispatients AT stefanhjacobson combinationofmalnutritioninflammationandfunctionalstatuslimitationsisassociatedwithmortalityinhemodialysispatients AT indranildasgupta combinationofmalnutritioninflammationandfunctionalstatuslimitationsisassociatedwithmortalityinhemodialysispatients AT brucemrobinson combinationofmalnutritioninflammationandfunctionalstatuslimitationsisassociatedwithmortalityinhemodialysispatients
_version_	1718387395839131648

The combination of malnutrition-inflammation and functional status limitations is associated with mortality in hemodialysis patients

Ejemplares similares