Increased Collagen Crosslinking in Stiff Clubfoot Tissue: Implications for the Improvement of Therapeutic Strategies
Congenital clubfoot is a complex musculoskeletal deformity, in which a stiff, contracted tissue forms in the medial part of the foot. Fibrotic changes are associated with increased collagen deposition and lysyl oxidase (LOX)-mediated crosslinking, which impair collagen degradation and increase the t...
Guardado en:
Autores principales: | Jarmila Knitlova, Martina Doubkova, Adam Eckhardt, Martin Ostadal, Jana Musilkova, Lucie Bacakova, Tomas Novotny |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
MDPI AG
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/a6d2094ae7d443bbaed9ca3c597d843f |
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