Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms
The plasmid-encoded MCR-1 enzyme modifies bacterial lipid A, thus conferring resistance to the antibiotic colistin. Here, Yang et al. show that MCR-1 expression can decrease in vitro growth rate, fitness and immune stimulation, and can reduce virulence in a Galleria mellonella infection model.
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Nature Portfolio
2017
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oai:doaj.org-article:a6d761a9e3b7476da168dbb04950f58a2021-12-02T14:42:51ZBalancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms10.1038/s41467-017-02149-02041-1723https://doaj.org/article/a6d761a9e3b7476da168dbb04950f58a2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02149-0https://doaj.org/toc/2041-1723The plasmid-encoded MCR-1 enzyme modifies bacterial lipid A, thus conferring resistance to the antibiotic colistin. Here, Yang et al. show that MCR-1 expression can decrease in vitro growth rate, fitness and immune stimulation, and can reduce virulence in a Galleria mellonella infection model.Qiue YangMei LiOwen B. SpillerDiego O. AndreyPhilip HinchliffeHui LiCraig MacLeanPannika NiumsupLydia PowellManon PritchardAndrei PapkouYingbo ShenEdward PortalKirsty SandsJames SpencerUttapoln TansawaiDavid ThomasShaolin WangYang WangJianzhong ShenTimothy WalshNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Qiue Yang Mei Li Owen B. Spiller Diego O. Andrey Philip Hinchliffe Hui Li Craig MacLean Pannika Niumsup Lydia Powell Manon Pritchard Andrei Papkou Yingbo Shen Edward Portal Kirsty Sands James Spencer Uttapoln Tansawai David Thomas Shaolin Wang Yang Wang Jianzhong Shen Timothy Walsh Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms |
| description |
The plasmid-encoded MCR-1 enzyme modifies bacterial lipid A, thus conferring resistance to the antibiotic colistin. Here, Yang et al. show that MCR-1 expression can decrease in vitro growth rate, fitness and immune stimulation, and can reduce virulence in a Galleria mellonella infection model. |
| format |
article |
| author |
Qiue Yang Mei Li Owen B. Spiller Diego O. Andrey Philip Hinchliffe Hui Li Craig MacLean Pannika Niumsup Lydia Powell Manon Pritchard Andrei Papkou Yingbo Shen Edward Portal Kirsty Sands James Spencer Uttapoln Tansawai David Thomas Shaolin Wang Yang Wang Jianzhong Shen Timothy Walsh |
| author_facet |
Qiue Yang Mei Li Owen B. Spiller Diego O. Andrey Philip Hinchliffe Hui Li Craig MacLean Pannika Niumsup Lydia Powell Manon Pritchard Andrei Papkou Yingbo Shen Edward Portal Kirsty Sands James Spencer Uttapoln Tansawai David Thomas Shaolin Wang Yang Wang Jianzhong Shen Timothy Walsh |
| author_sort |
Qiue Yang |
| title |
Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms |
| title_short |
Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms |
| title_full |
Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms |
| title_fullStr |
Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms |
| title_full_unstemmed |
Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms |
| title_sort |
balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/a6d761a9e3b7476da168dbb04950f58a |
| work_keys_str_mv |
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