Comparison of endoscopic and microscopic transsphenoidal pituitary surgery for managing growth hormone-secreting adenomas

Pituitary adenomas are benign tumors with various biological behaviors, including hormonal secretion, cavernous sinus invasion and others. This study aimed to access the advantages and disadvantages of the endoscopic endonasal transsphenoidal (EET) approach for managing growth hormone-secreting aden...

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Autores principales: Asen Hadzhiyanev, Deyan Popov
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Lenguaje:EN
Publicado: Taylor & Francis Group 2021
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spelling oai:doaj.org-article:a6d7814c90c6450c95977874bb5e43772021-11-11T14:23:41ZComparison of endoscopic and microscopic transsphenoidal pituitary surgery for managing growth hormone-secreting adenomas1310-28181314-353010.1080/13102818.2021.1996273https://doaj.org/article/a6d7814c90c6450c95977874bb5e43772021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13102818.2021.1996273https://doaj.org/toc/1310-2818https://doaj.org/toc/1314-3530Pituitary adenomas are benign tumors with various biological behaviors, including hormonal secretion, cavernous sinus invasion and others. This study aimed to access the advantages and disadvantages of the endoscopic endonasal transsphenoidal (EET) approach for managing growth hormone-secreting adenomas in achieving clinical remission compared to the microscopic endonasal transsphenoidal (MET) approach. From 2017 to 2020, a series of 29 patients with growth hormone-secreting adenomas (GH) underwent the surgical treatment via MET (n = 13) and EET (n = 16) approach. Preoperatively and postoperatively endocrinological, neuro-ophthalmological and magnetic resonance imaging (MRI) examinations were performed. According to the Knosp classification for cavernous sinus, 34.4% of all adenomas were accessed as invasive. The mean follow-up was 21.6 ± 12.2 months. The endocrinological remission in the whole group was 68.9%. The microscopic group had lower levels of remission in comparison to the endoscopic group (61.53% vs. 75%). However, no significant difference was observed (р > 0.05). Postoperative diabetes insipidus and cerebrospinal fluid (CSF) leaks rates had a similar occurrence in both groups. No other significant complications were recognized. The use of endoscopic approaches provides a couple of advantages, such as wider field of view, superior illumination and better maneuverability compared to conventional microsurgery. A longer follow-up is still needed for further evaluation of our results.Asen HadzhiyanevDeyan PopovTaylor & Francis Grouparticlegrowth hormone-secreting adenomasendoscopic approachmicroscopic approachBiotechnologyTP248.13-248.65ENBiotechnology & Biotechnological Equipment, Vol 35, Iss 1, Pp 1534-1537 (2021)
institution DOAJ
collection DOAJ
language EN
topic growth hormone-secreting adenomas
endoscopic approach
microscopic approach
Biotechnology
TP248.13-248.65
spellingShingle growth hormone-secreting adenomas
endoscopic approach
microscopic approach
Biotechnology
TP248.13-248.65
Asen Hadzhiyanev
Deyan Popov
Comparison of endoscopic and microscopic transsphenoidal pituitary surgery for managing growth hormone-secreting adenomas
description Pituitary adenomas are benign tumors with various biological behaviors, including hormonal secretion, cavernous sinus invasion and others. This study aimed to access the advantages and disadvantages of the endoscopic endonasal transsphenoidal (EET) approach for managing growth hormone-secreting adenomas in achieving clinical remission compared to the microscopic endonasal transsphenoidal (MET) approach. From 2017 to 2020, a series of 29 patients with growth hormone-secreting adenomas (GH) underwent the surgical treatment via MET (n = 13) and EET (n = 16) approach. Preoperatively and postoperatively endocrinological, neuro-ophthalmological and magnetic resonance imaging (MRI) examinations were performed. According to the Knosp classification for cavernous sinus, 34.4% of all adenomas were accessed as invasive. The mean follow-up was 21.6 ± 12.2 months. The endocrinological remission in the whole group was 68.9%. The microscopic group had lower levels of remission in comparison to the endoscopic group (61.53% vs. 75%). However, no significant difference was observed (р > 0.05). Postoperative diabetes insipidus and cerebrospinal fluid (CSF) leaks rates had a similar occurrence in both groups. No other significant complications were recognized. The use of endoscopic approaches provides a couple of advantages, such as wider field of view, superior illumination and better maneuverability compared to conventional microsurgery. A longer follow-up is still needed for further evaluation of our results.
format article
author Asen Hadzhiyanev
Deyan Popov
author_facet Asen Hadzhiyanev
Deyan Popov
author_sort Asen Hadzhiyanev
title Comparison of endoscopic and microscopic transsphenoidal pituitary surgery for managing growth hormone-secreting adenomas
title_short Comparison of endoscopic and microscopic transsphenoidal pituitary surgery for managing growth hormone-secreting adenomas
title_full Comparison of endoscopic and microscopic transsphenoidal pituitary surgery for managing growth hormone-secreting adenomas
title_fullStr Comparison of endoscopic and microscopic transsphenoidal pituitary surgery for managing growth hormone-secreting adenomas
title_full_unstemmed Comparison of endoscopic and microscopic transsphenoidal pituitary surgery for managing growth hormone-secreting adenomas
title_sort comparison of endoscopic and microscopic transsphenoidal pituitary surgery for managing growth hormone-secreting adenomas
publisher Taylor & Francis Group
publishDate 2021
url https://doaj.org/article/a6d7814c90c6450c95977874bb5e4377
work_keys_str_mv AT asenhadzhiyanev comparisonofendoscopicandmicroscopictranssphenoidalpituitarysurgeryformanaginggrowthhormonesecretingadenomas
AT deyanpopov comparisonofendoscopicandmicroscopictranssphenoidalpituitarysurgeryformanaginggrowthhormonesecretingadenomas
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