MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts

Accumulations of R-loops can lead to genome instability. Here the authors reveal a role for the MRN complex in suppressing R-loops and associated DNA damage at transcription–replication conflicts.

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Autores principales:	Emily Yun-Chia Chang, Shuhe Tsai, Maria J. Aristizabal, James P. Wells, Yan Coulombe, Franciele F. Busatto, Yujia A. Chan, Arun Kumar, Yi Dan Zhu, Alan Ying-Hsu Wang, Louis-Alexandre Fournier, Philip Hieter, Michael S. Kobor, Jean-Yves Masson, Peter C. Stirling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a6da048a2a604ec29f09e5727eff77ce
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spelling	oai:doaj.org-article:a6da048a2a604ec29f09e5727eff77ce2021-12-02T14:38:46ZMRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts10.1038/s41467-019-12271-w2041-1723https://doaj.org/article/a6da048a2a604ec29f09e5727eff77ce2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12271-whttps://doaj.org/toc/2041-1723Accumulations of R-loops can lead to genome instability. Here the authors reveal a role for the MRN complex in suppressing R-loops and associated DNA damage at transcription–replication conflicts.Emily Yun-Chia ChangShuhe TsaiMaria J. AristizabalJames P. WellsYan CoulombeFranciele F. BusattoYujia A. ChanArun KumarYi Dan ZhuAlan Ying-Hsu WangLouis-Alexandre FournierPhilip HieterMichael S. KoborJean-Yves MassonPeter C. StirlingNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emily Yun-Chia Chang Shuhe Tsai Maria J. Aristizabal James P. Wells Yan Coulombe Franciele F. Busatto Yujia A. Chan Arun Kumar Yi Dan Zhu Alan Ying-Hsu Wang Louis-Alexandre Fournier Philip Hieter Michael S. Kobor Jean-Yves Masson Peter C. Stirling MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts
description	Accumulations of R-loops can lead to genome instability. Here the authors reveal a role for the MRN complex in suppressing R-loops and associated DNA damage at transcription–replication conflicts.
format	article
author	Emily Yun-Chia Chang Shuhe Tsai Maria J. Aristizabal James P. Wells Yan Coulombe Franciele F. Busatto Yujia A. Chan Arun Kumar Yi Dan Zhu Alan Ying-Hsu Wang Louis-Alexandre Fournier Philip Hieter Michael S. Kobor Jean-Yves Masson Peter C. Stirling
author_facet	Emily Yun-Chia Chang Shuhe Tsai Maria J. Aristizabal James P. Wells Yan Coulombe Franciele F. Busatto Yujia A. Chan Arun Kumar Yi Dan Zhu Alan Ying-Hsu Wang Louis-Alexandre Fournier Philip Hieter Michael S. Kobor Jean-Yves Masson Peter C. Stirling
author_sort	Emily Yun-Chia Chang
title	MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts
title_short	MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts
title_full	MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts
title_fullStr	MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts
title_full_unstemmed	MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts
title_sort	mre11-rad50-nbs1 promotes fanconi anemia r-loop suppression at transcription–replication conflicts
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a6da048a2a604ec29f09e5727eff77ce
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MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts

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