Clinical Impact of Liraglutide as a Treatment of Obesity

Heshma Alruwaili,1 Babak Dehestani,1 Carel W le Roux1,2 1Diabetes Complications Research Centre, Conway Institute, University College Dublin, Dublin, Ireland; 2Diabetes Research Group, School of Biomedical Sciences, Ulster University, Belfast, UKCorrespondence: Heshma Alruwaili Email alruwaily85@hot...

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Autores principales:	Alruwaili H, Dehestani B, le Roux CW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	liraglutide obesity weight loss glp-1 analogue Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/a6dd020fdd0549d2a9e2f4e412d332e9
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spelling	oai:doaj.org-article:a6dd020fdd0549d2a9e2f4e412d332e92021-12-02T13:30:28ZClinical Impact of Liraglutide as a Treatment of Obesity1179-1438https://doaj.org/article/a6dd020fdd0549d2a9e2f4e412d332e92021-03-01T00:00:00Zhttps://www.dovepress.com/clinical-impact-of-liraglutide-as-a-treatment-of-obesity-peer-reviewed-article-CPAAhttps://doaj.org/toc/1179-1438Heshma Alruwaili,1 Babak Dehestani,1 Carel W le Roux1,2 1Diabetes Complications Research Centre, Conway Institute, University College Dublin, Dublin, Ireland; 2Diabetes Research Group, School of Biomedical Sciences, Ulster University, Belfast, UKCorrespondence: Heshma Alruwaili Email alruwaily85@hotmail.comAbstract: Obesity is defined as a chronic, complex, relapsing disease characterized by excessive adipose tissue. Obesity impacts an individual’s health by increasing complications such as prediabetes, type 2 diabetes mellitus (T2DM), hypertension, dyslipidemia, metabolic syndrome, cardiovascular disease, nonalcoholic fatty liver disease (NAFLD), cancers (eg endometrial), and obstructive sleep apnea (OSA). With the increase of obesity prevalence and its negative influences on individuals’ quality of life, there is a great need for therapy with a purpose to produce sustainable weight loss of more than 10% in order to improve or even reverse the progress of obesity related complications. The GLP-1 analogue, liraglutide reduce food consumption, promote weight reduction and improve metabolic functions. The primary mechanism of GLP-1 effect on food intake, metabolism, and weight reduction is mainly due to its actions on peripheral (vagal) and central pathways and activation of hindbrain and hypothalamus. The average weight reduction induced by liraglutide was significant and the weight loss was maintained as long as the patients on therapy. Liraglutide has advantages on weight loss maintenance and promoting cardiovascular disease (CVD) risk reduction, by decreasing systolic blood pressure and glycemic index. In this review, we aim to explain the mechanism of action of Liraglutide, its pharmacokinetic properties, its clinical impact on obesity and its safety and tolerability.Keywords: liraglutide, obesity, weight loss, GLP-1 analogueAlruwaili HDehestani Ble Roux CWDove Medical Pressarticleliraglutideobesityweight lossglp-1 analogueTherapeutics. PharmacologyRM1-950ENClinical Pharmacology: Advances and Applications, Vol Volume 13, Pp 53-60 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	liraglutide obesity weight loss glp-1 analogue Therapeutics. Pharmacology RM1-950
spellingShingle	liraglutide obesity weight loss glp-1 analogue Therapeutics. Pharmacology RM1-950 Alruwaili H Dehestani B le Roux CW Clinical Impact of Liraglutide as a Treatment of Obesity
description	Heshma Alruwaili,1 Babak Dehestani,1 Carel W le Roux1,2 1Diabetes Complications Research Centre, Conway Institute, University College Dublin, Dublin, Ireland; 2Diabetes Research Group, School of Biomedical Sciences, Ulster University, Belfast, UKCorrespondence: Heshma Alruwaili Email alruwaily85@hotmail.comAbstract: Obesity is defined as a chronic, complex, relapsing disease characterized by excessive adipose tissue. Obesity impacts an individual’s health by increasing complications such as prediabetes, type 2 diabetes mellitus (T2DM), hypertension, dyslipidemia, metabolic syndrome, cardiovascular disease, nonalcoholic fatty liver disease (NAFLD), cancers (eg endometrial), and obstructive sleep apnea (OSA). With the increase of obesity prevalence and its negative influences on individuals’ quality of life, there is a great need for therapy with a purpose to produce sustainable weight loss of more than 10% in order to improve or even reverse the progress of obesity related complications. The GLP-1 analogue, liraglutide reduce food consumption, promote weight reduction and improve metabolic functions. The primary mechanism of GLP-1 effect on food intake, metabolism, and weight reduction is mainly due to its actions on peripheral (vagal) and central pathways and activation of hindbrain and hypothalamus. The average weight reduction induced by liraglutide was significant and the weight loss was maintained as long as the patients on therapy. Liraglutide has advantages on weight loss maintenance and promoting cardiovascular disease (CVD) risk reduction, by decreasing systolic blood pressure and glycemic index. In this review, we aim to explain the mechanism of action of Liraglutide, its pharmacokinetic properties, its clinical impact on obesity and its safety and tolerability.Keywords: liraglutide, obesity, weight loss, GLP-1 analogue
format	article
author	Alruwaili H Dehestani B le Roux CW
author_facet	Alruwaili H Dehestani B le Roux CW
author_sort	Alruwaili H
title	Clinical Impact of Liraglutide as a Treatment of Obesity
title_short	Clinical Impact of Liraglutide as a Treatment of Obesity
title_full	Clinical Impact of Liraglutide as a Treatment of Obesity
title_fullStr	Clinical Impact of Liraglutide as a Treatment of Obesity
title_full_unstemmed	Clinical Impact of Liraglutide as a Treatment of Obesity
title_sort	clinical impact of liraglutide as a treatment of obesity
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/a6dd020fdd0549d2a9e2f4e412d332e9
work_keys_str_mv	AT alruwailih clinicalimpactofliraglutideasatreatmentofobesity AT dehestanib clinicalimpactofliraglutideasatreatmentofobesity AT lerouxcw clinicalimpactofliraglutideasatreatmentofobesity
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Clinical Impact of Liraglutide as a Treatment of Obesity

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