ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment

Advanced ovarian cancer usually spreads to the omentum. Here, the authors show that circulating intelectin-1 (ITLN1) has prognostic significance in patients with advanced ovarian cancer, and that mesothelial cell-derived ITLN1 in the omental tumor microenvironment suppresses ovarian cancer progressi...

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Autores principales:	Chi-Lam Au-Yeung, Tsz-Lun Yeung, Abhinav Achreja, Hongyun Zhao, Kay-Pong Yip, Suet-Ying Kwan, Michaela Onstad, Jianting Sheng, Ying Zhu, Dodge L. Baluya, Ngai-Na Co, Angela Rynne-Vidal, Rosemarie Schmandt, Matthew L. Anderson, Karen H. Lu, Stephen T. C. Wong, Deepak Nagrath, Samuel C. Mok
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a6dd5cbe55934dbcaae176ed33be66a7
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spelling	oai:doaj.org-article:a6dd5cbe55934dbcaae176ed33be66a72021-12-02T17:01:22ZITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment10.1038/s41467-020-17383-22041-1723https://doaj.org/article/a6dd5cbe55934dbcaae176ed33be66a72020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17383-2https://doaj.org/toc/2041-1723Advanced ovarian cancer usually spreads to the omentum. Here, the authors show that circulating intelectin-1 (ITLN1) has prognostic significance in patients with advanced ovarian cancer, and that mesothelial cell-derived ITLN1 in the omental tumor microenvironment suppresses ovarian cancer progression.Chi-Lam Au-YeungTsz-Lun YeungAbhinav AchrejaHongyun ZhaoKay-Pong YipSuet-Ying KwanMichaela OnstadJianting ShengYing ZhuDodge L. BaluyaNgai-Na CoAngela Rynne-VidalRosemarie SchmandtMatthew L. AndersonKaren H. LuStephen T. C. WongDeepak NagrathSamuel C. MokNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chi-Lam Au-Yeung Tsz-Lun Yeung Abhinav Achreja Hongyun Zhao Kay-Pong Yip Suet-Ying Kwan Michaela Onstad Jianting Sheng Ying Zhu Dodge L. Baluya Ngai-Na Co Angela Rynne-Vidal Rosemarie Schmandt Matthew L. Anderson Karen H. Lu Stephen T. C. Wong Deepak Nagrath Samuel C. Mok ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment
description	Advanced ovarian cancer usually spreads to the omentum. Here, the authors show that circulating intelectin-1 (ITLN1) has prognostic significance in patients with advanced ovarian cancer, and that mesothelial cell-derived ITLN1 in the omental tumor microenvironment suppresses ovarian cancer progression.
format	article
author	Chi-Lam Au-Yeung Tsz-Lun Yeung Abhinav Achreja Hongyun Zhao Kay-Pong Yip Suet-Ying Kwan Michaela Onstad Jianting Sheng Ying Zhu Dodge L. Baluya Ngai-Na Co Angela Rynne-Vidal Rosemarie Schmandt Matthew L. Anderson Karen H. Lu Stephen T. C. Wong Deepak Nagrath Samuel C. Mok
author_facet	Chi-Lam Au-Yeung Tsz-Lun Yeung Abhinav Achreja Hongyun Zhao Kay-Pong Yip Suet-Ying Kwan Michaela Onstad Jianting Sheng Ying Zhu Dodge L. Baluya Ngai-Na Co Angela Rynne-Vidal Rosemarie Schmandt Matthew L. Anderson Karen H. Lu Stephen T. C. Wong Deepak Nagrath Samuel C. Mok
author_sort	Chi-Lam Au-Yeung
title	ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment
title_short	ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment
title_full	ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment
title_fullStr	ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment
title_full_unstemmed	ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment
title_sort	itln1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a6dd5cbe55934dbcaae176ed33be66a7
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ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment

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