A pilot study investigating the use of 4D flow MRI for the assessment of splanchnic flow in patients suspected of mesenteric ischaemia

Abstract The most common cause of chronic mesenteric ischaemia is atherosclerosis which results in limitation of blood flow to the gastrointestinal tract. This pilot study aimed to evaluate 4D flow MRI as a potential tool for the analysis of blood flow changes post-prandial within the mesenteric ves...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Pauline Hall Barrientos, Katrina Knight, Douglas Black, Alexander Vesey, Giles Roditi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a6deddba3b874f76bb9f723ba1d74900
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a6deddba3b874f76bb9f723ba1d74900
record_format	dspace
spelling	oai:doaj.org-article:a6deddba3b874f76bb9f723ba1d749002021-12-02T13:17:55ZA pilot study investigating the use of 4D flow MRI for the assessment of splanchnic flow in patients suspected of mesenteric ischaemia10.1038/s41598-021-85315-12045-2322https://doaj.org/article/a6deddba3b874f76bb9f723ba1d749002021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85315-1https://doaj.org/toc/2045-2322Abstract The most common cause of chronic mesenteric ischaemia is atherosclerosis which results in limitation of blood flow to the gastrointestinal tract. This pilot study aimed to evaluate 4D flow MRI as a potential tool for the analysis of blood flow changes post-prandial within the mesenteric vessels. The mesenteric vessels of twelve people were scanned; patients and healthy volunteers. A baseline MRI scan was performed after 6 h of fasting followed by a post-meal scan. Two 4D flow datasets were acquired, over the superior mesenteric artery (SMA) and the main portal venous vessels. Standard 2D time-resolved PC-MRI slices were also obtained across the aorta above the coeliac trunk, superior mesenteric vein, splenic vein and portal vein (PV). In the volunteer cohort there was a marked increase in blood flow post-meal within the PV (p = 0.028), not seen in the patient cohort (p = 0.116). Similarly, there were significant flow changes within the SMA of volunteers (p = 0.028) but not for the patient group (p = 0.116). Our pilot data has shown that there is a significant haemodynamic response to meal challenge in the PV and SMA in normal subjects compared to clinically apparent CMI patients. Therefore, the interrogation of mesenteric venous vessels exclusively is a feasible method to measure post-prandial flow changes in CMI patients.Pauline Hall BarrientosKatrina KnightDouglas BlackAlexander VeseyGiles RoditiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pauline Hall Barrientos Katrina Knight Douglas Black Alexander Vesey Giles Roditi A pilot study investigating the use of 4D flow MRI for the assessment of splanchnic flow in patients suspected of mesenteric ischaemia
description	Abstract The most common cause of chronic mesenteric ischaemia is atherosclerosis which results in limitation of blood flow to the gastrointestinal tract. This pilot study aimed to evaluate 4D flow MRI as a potential tool for the analysis of blood flow changes post-prandial within the mesenteric vessels. The mesenteric vessels of twelve people were scanned; patients and healthy volunteers. A baseline MRI scan was performed after 6 h of fasting followed by a post-meal scan. Two 4D flow datasets were acquired, over the superior mesenteric artery (SMA) and the main portal venous vessels. Standard 2D time-resolved PC-MRI slices were also obtained across the aorta above the coeliac trunk, superior mesenteric vein, splenic vein and portal vein (PV). In the volunteer cohort there was a marked increase in blood flow post-meal within the PV (p = 0.028), not seen in the patient cohort (p = 0.116). Similarly, there were significant flow changes within the SMA of volunteers (p = 0.028) but not for the patient group (p = 0.116). Our pilot data has shown that there is a significant haemodynamic response to meal challenge in the PV and SMA in normal subjects compared to clinically apparent CMI patients. Therefore, the interrogation of mesenteric venous vessels exclusively is a feasible method to measure post-prandial flow changes in CMI patients.
format	article
author	Pauline Hall Barrientos Katrina Knight Douglas Black Alexander Vesey Giles Roditi
author_facet	Pauline Hall Barrientos Katrina Knight Douglas Black Alexander Vesey Giles Roditi
author_sort	Pauline Hall Barrientos
title	A pilot study investigating the use of 4D flow MRI for the assessment of splanchnic flow in patients suspected of mesenteric ischaemia
title_short	A pilot study investigating the use of 4D flow MRI for the assessment of splanchnic flow in patients suspected of mesenteric ischaemia
title_full	A pilot study investigating the use of 4D flow MRI for the assessment of splanchnic flow in patients suspected of mesenteric ischaemia
title_fullStr	A pilot study investigating the use of 4D flow MRI for the assessment of splanchnic flow in patients suspected of mesenteric ischaemia
title_full_unstemmed	A pilot study investigating the use of 4D flow MRI for the assessment of splanchnic flow in patients suspected of mesenteric ischaemia
title_sort	pilot study investigating the use of 4d flow mri for the assessment of splanchnic flow in patients suspected of mesenteric ischaemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a6deddba3b874f76bb9f723ba1d74900
work_keys_str_mv	AT paulinehallbarrientos apilotstudyinvestigatingtheuseof4dflowmrifortheassessmentofsplanchnicflowinpatientssuspectedofmesentericischaemia AT katrinaknight apilotstudyinvestigatingtheuseof4dflowmrifortheassessmentofsplanchnicflowinpatientssuspectedofmesentericischaemia AT douglasblack apilotstudyinvestigatingtheuseof4dflowmrifortheassessmentofsplanchnicflowinpatientssuspectedofmesentericischaemia AT alexandervesey apilotstudyinvestigatingtheuseof4dflowmrifortheassessmentofsplanchnicflowinpatientssuspectedofmesentericischaemia AT gilesroditi apilotstudyinvestigatingtheuseof4dflowmrifortheassessmentofsplanchnicflowinpatientssuspectedofmesentericischaemia AT paulinehallbarrientos pilotstudyinvestigatingtheuseof4dflowmrifortheassessmentofsplanchnicflowinpatientssuspectedofmesentericischaemia AT katrinaknight pilotstudyinvestigatingtheuseof4dflowmrifortheassessmentofsplanchnicflowinpatientssuspectedofmesentericischaemia AT douglasblack pilotstudyinvestigatingtheuseof4dflowmrifortheassessmentofsplanchnicflowinpatientssuspectedofmesentericischaemia AT alexandervesey pilotstudyinvestigatingtheuseof4dflowmrifortheassessmentofsplanchnicflowinpatientssuspectedofmesentericischaemia AT gilesroditi pilotstudyinvestigatingtheuseof4dflowmrifortheassessmentofsplanchnicflowinpatientssuspectedofmesentericischaemia
_version_	1718393349091622912

A pilot study investigating the use of 4D flow MRI for the assessment of splanchnic flow in patients suspected of mesenteric ischaemia

Ejemplares similares